Psychobiotics and Their Involvement in Mental Health

Tang, Fengyi; Reddy, Bhaskara L.; Saier, Milton H.

doi:10.1159/000366281

Cited by 17 publications

(18 citation statements)

References 36 publications

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“…Microbe-derived neurotransmitters or neuroactive molecules from enterocytes under control of gut microbes influence the neural signaling of this gut–brain axis [2] . The proinflammatory, anti-inflammatory, and serotonergic signals are imperative for modulating sleep, appetite, mood, and cognition [5] . Experimentally, mice with altered intestinal flora (induced by vancomycin) and germ-free mice (devoid of gut flora) displayed features of anxiety, depression, and abnormal stress response, which were reversible on restoration of eubiosis by fecal transplant [2] .…”

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confidence: 99%

Psychobiotics: An emerging probiotic in psychiatric practice

Kali

2016

Biomedical Journal

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Intestinal microbial flora plays critical role in maintenance of health. Probiotic organisms have been recognized as an essential therapeutic component in the treatment of intestinal dysbiosis. Current research suggests their health benefits extends beyond intestinal disorders. The neuroactive molecules produced by the gut microbiota has been found to modulate neural signals which affect neurological and psychiatric parameters like sleep, appetite, mood and cognition. Use of these novel probiotics opens up the possibility of restructuring of intestinal microbiota for effective management of various psychiatric disorders.

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confidence: 99%

Psychobiotics: An emerging probiotic in psychiatric practice

Kali

2016

Biomedical Journal

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“…Studies demonstrating the therapeutic efficacy of gut microbial manipulations are numerous and include the following: studies in germ-free animals, infection studies, pro and antibiotic manipulation, and fecal transplant [5][6][7][8]. So much progress has been made developing probiotic therapies with regard to psychiatric disorders that an entire class of developing therapeutics has been dubbed "psychobiotics" [4,9].…”

Section: Introductionmentioning

confidence: 99%

“…The basic principle behind psychobiotics is that microorganisms can be introduced that either directly or through their impact on the rest of the microbiome lead to a psychotherapeutic effect. Thus far, the most successful psychobiotics have been tested as antidepressants and anxiolytics [4,6,7,10]. Designer probiotics have begun to be developed as well.…”

Section: Introductionmentioning

confidence: 99%

Tuning the Brain-Gut Axis in Health and Disease

2015

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Recent breakthroughs in gut microbiome-derived technologies and therapies, coupled with the lack of invasiveness associated with them, provide attractive routes of biomarker and therapeutic development. Alongside such breakthroughs, an ever-growing body of literature indicates a strong connection between brain activity and microbial populations in the gut. The paucity of effective psychiatric therapies makes the gut microbiota/brain connection a particularly enticing field. This article reviews some of the mechanisms of connection between the gut and the brain, their potential relationship to psychiatric disorders, and the therapeutic potential that arises from them.

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“…However, it must also be recalled that exposure to microorganisms is largely responsible for the development of the immune system, and insufficient exposure can lead to a variety of health-threatening conditions such as asthma and certain types of allergies [Lynch and Boushey, 2016]. We now know that all of us depend on our bodily microbiome for both physical and mental health [Dinan and Cryan, 2017; Reddy and Saier, 2015; Rieder et al, 2017; Tang et al, 2014]. Thus, we need to rely on scientific discoveries as they unfold to determine our best courses of action.…”

mentioning

confidence: 99%