Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial

Bilderbeck, Amy C.; Atkinson, Lauren Z; McMahon, Hannah; Voysey, Merryn; Simon, Judit; Price, Jonathan; Rendell, Jennifer M; Hinds, Chris; Geddes, John; Holmes, Emily A.; Miklowitz, David J.; Goodwin, Guy M.

doi:10.1016/j.jad.2016.06.064

Cited by 26 publications

(17 citation statements)

References 32 publications

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“…Screening, informed consent, assessments, allocation to condition, and the delivery of the intervention were carried out online using an automated system, a specially configured instance of True Colours, which is a system for the scheduled collection of outcome measures. 14 Participants in the control group were given access to the sleep intervention after their final assessment. The study received overall ethical approval from the University of Oxford Medical Sciences Inter-Divisional Ethics Committee and then local approvals at the other participating universities.…”

Section: Methodsmentioning

confidence: 99%

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

Freeman

Sheaves

Goodwin

et al. 2017

The Lancet Psychiatry

532

408

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SummaryBackgroundSleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations.MethodsWe did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251.FindingsBetween March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (−2·22, −2·98 to −1·45, Cohen's d=0·19; p<0·0001), and hallucinations (−1·58, −1·98 to −1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported.InterpretationTo our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision.FundingWellcome Trust.

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Section: Methodsmentioning

confidence: 99%

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

Freeman

Sheaves

Goodwin

et al. 2017

The Lancet Psychiatry

532

408

View full text Add to dashboard Cite

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“…Patients randomly assigned to the self-administered program received the Facilitated Integrated Mood Management Intervention manual though did not have any interaction with study therapists. Self-reported depression and mania symptoms did not differ between the groups through the 12-month follow-up period though patients in the Facilitated intervention reported a greater understanding of the bipolar illness at 3-month follow-up, which was associated with more weeks well at 12-month follow-up [51]. Though it is not possible to comment on the independent contribution of the social rhythm-focused elements of the intervention(s), these studies suggest that a mood management program combining elements from varied bipolar psychosocial interventions (including treatment targets focusing on social rhythm regularity) may be effective for patients with BD and also provide some initial evidence that self-administered programs may not be able to replace clinician-guided interventions.…”

Section: Other Recent Social Rhythm-focused Interventionsmentioning

confidence: 83%

“…A pilot study of this intervention found that it was effective in promoting mood stability and that patients increased their knowledge of mood management strategies from pre-to post-treatment [50]. A recent randomized study assigned patients (n = 121) to receive the 5-session Facilitated Integrated Mood Management intervention or a selfdelivered format of the intervention (Manualized Integrated Mood Management) over a 12week period [51]. Patients randomly assigned to the self-administered program received the Facilitated Integrated Mood Management Intervention manual though did not have any interaction with study therapists.…”

Section: Other Recent Social Rhythm-focused Interventionsmentioning

confidence: 99%

Treating Circadian Rhythm Disruption in Bipolar Disorder

Gold

Kinrys

2019

Curr Psychiatry Rep

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Purpose of Review-Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). This review evaluates recent studies on the treatment of circadian dysfunction in BD. Recent Findings-Targeted social rhythm therapy may be useful for bipolar depression though some studies suggest that a non-targeted psychosocial or pharmacological intervention may be just as efficacious. Lithium holds potential for addressing circadian dysfunction in BD. Blue-blocking therapy may be useful for mania and midday bright light therapy may relieve depression. Conclusions-Psychosocial, pharmacological, and light-based approaches are promising avenues for treating circadian dysfunction in BD.

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“…Although the present paper concerns the use of smartphones for objective monitoring in bipolar disorder, it should be emphasized that currently there is a lack of randomized controlled trials investigating the possible positive, negative, and neutral effects as well as economical evaluations of smartphone-based treatment interventions (Faurholt-Jepsen et al 2015a ; Depp et al 2015 ; Bilderbeck et al 2016 ).…”

Section: Considerations and Future Studiesmentioning

confidence: 99%

Smartphone-based objective monitoring in bipolar disorder: status and considerations

Faurholt‐Jepsen

Bauer

Kessing

2018

Int J Bipolar Disord

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In 2001, the WHO stated that: “The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across the globe”. Within mental health, interventions and monitoring systems for depression, anxiety, substance abuse, eating disorder, schizophrenia and bipolar disorder have been developed and used. The present paper presents the status and findings from studies using automatically generated objective smartphone data in the monitoring of bipolar disorder, and addresses considerations on the current literature and methodological as well as clinical aspects to consider in the future studies.

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Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial

Cited by 26 publications

References 32 publications

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

Treating Circadian Rhythm Disruption in Bipolar Disorder

Smartphone-based objective monitoring in bipolar disorder: status and considerations

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