Psychoeducation Improves Hepatitis C Virus Treatment During Opioid Substitution Therapy: A Controlled, Prospective Multicenter Trial

Reimer, Jens; Schmidt, Christiane Sybille; Schulte, Bernd; Gansefort, Dirk; Gölz, Jörg; Gerken, Guido; Scherbaum, Norbert; Verthein, Uwe; Backmund, Markus

doi:10.1093/cid/cit307

Cited by 17 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These programs may involve collaborations between physicians specializing in internal medicine, addiction, and hepatology (Carrion et al, 2013; Curcio et al, 2010; Ho et al, 2013), and between physicians and nursing support staff (Larrey et al, 2011), with a focus on multidisciplinary psychoeducation (Hussein et al, 2010; Reimer et al, 2013). Many of these studies were non-randomized or were subject to selection bias; other limitations are detailed further in Table 4.…”

Section: Results: Intervention Strategiesmentioning

confidence: 99%

Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum

Meyer

Moghimi

Marcus

et al. 2015

International Journal of Drug Policy

104

View full text Add to dashboard Cite

Background With the explosion of newly available, direct acting antiviral (DAA) Hepatitis C virus (HCV) treatments that demonstrate 95% sustained virologic response (SVR) rates, evidence-based strategies are urgently needed to achieve real-world effectiveness in challenging patient populations. While HIV is incurable, lessons from over 30 years of experience overcoming obstacles to the HIV treatment cascade could be applied to the HCV context. Methods Using Institute of Medicine guidelines, we conducted a systematic review of published interventions from PubMed, Medline, GoogleScholar, EmBASE, and PsychInfo bibliographic databases and citation indices. Abstracts were first screened by three independent reviewers and studies were included if they involved original research, described a specific intervention, were published in English in a peer-reviewed journal between 2001 and 2014, and had full text available. Results Evidence-based interventions to enhance HCV assessment, treatment, and adherence generally fell into one of 4 categories, including those involving: 1) Diagnosis or case-finding; 2) Linkage to HCV care; 3) Pre-therapeutic evaluation or treatment initiation; or 4) Treatment adherence. While most available eligible studies described interventions using non-contemporary interferon-based HCV treatments, future research will need to address how these interventions apply to the context of well-tolerated, simple, oral treatment regimens. In some cases, we explored how HIV-specific interventions might be modified to fit the HCV spectrum of care engagement. Conclusions Evidence-based interventions should be strategically incorporated into HCV treatment implementation efforts to most effectively deliver treatment and maximize treatment outcomes.

show abstract

Section: Results: Intervention Strategiesmentioning

confidence: 99%

Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum

Meyer

Moghimi

Marcus

et al. 2015

International Journal of Drug Policy

104

View full text Add to dashboard Cite

show abstract

“…Additionally, research has shown that active PWID living with HIV can adhere to HIV medications, leading to successful viral suppression (Sherer, 1998). Even when HCV treatment regimens were more complex, studies have demonstrated successful adherence in PWID using a multi-pronged approach (Jeffrey et al, 2007; Reimer et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

‘Hep C’s like the common cold’: understanding barriers along the HCV care continuum among young people who inject drugs

Skeer

Ladin

Wilkins

et al. 2018

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…Many practitioners stated that they did not feel that offering it was appropriate in all stages of treatment and that a harm reduction kit was not appropriate for patients receiving DAA. In contrast, studies using a multipronged approach have, in fact, demonstrated successful treatment in PWID [35][36][37][38][39][40]. This signals a lack of knowledge among practitioners, which contributes to poorer health outcomes [27].…”

Section: Discussionmentioning

confidence: 99%

Barriers to effective management of hepatitis C virus in people who inject drugs: Evidence from outpatient clinics

Molinaro

Resce

Alberti

et al. 2019

Drug and Alcohol Review

View full text Add to dashboard Cite

Introduction and Aims People who inject drugs (PWID) constitute the largest reservoir of hepatitis C virus (HCV). Although effective medications are available and access to care is universal in Italy, the proportion of PWID receiving appropriate care remains low. Design and Methods To identify the major barriers for PWID to HCV treatment we surveyed a large sample of practitioners working in outpatient addiction centres (SerDs). The survey was conducted in two stages and involved 30.3% of SerDs operating in Italy. In the first, SerD physicians completed a questionnaire designed with a Delphi structure. In the second, SerD practitioners completed a targeted questionnaire to identify barriers to four SerD services in HCV management: screening, referral, treatment and harm reduction. Results The first‐stage questionnaire, in which a Delphi and RAND‐UCLA method was used, revealed a lack of agreement among the physicians about barriers to health care. The more detailed second‐stage questionnaire indicated the barriers to delivering specific SerD services. As regarded the delivery of all four services, the major reasons for treating <50% of patients were: physician and nurse understaffing, technical, economic and logistic issues. In contrast, the practitioners who responded that they follow protocol recommendations often deliver all four services to >50% of patients. Discussion and Conclusions HCV treatment remains out of reach for many PWID attending a drug treatment centre in Italy. To meet the World Health Organisation (WHO) target, there is a need to increase economic, technical and staff support at treatment centres using the protocols and the universal health care already in place.

show abstract

Psychoeducation Improves Hepatitis C Virus Treatment During Opioid Substitution Therapy: A Controlled, Prospective Multicenter Trial

Abstract: In patients with a higher risk of dropout due to GT 1/4 or mental distress, PE was shown to improve retention and SVR. PE is an effective supportive intervention for HCV therapy among PWID.

Cited by 17 publications

References 17 publications

Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum

Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum

‘Hep C’s like the common cold’: understanding barriers along the HCV care continuum among young people who inject drugs

Barriers to effective management of hepatitis C virus in people who inject drugs: Evidence from outpatient clinics

Contact Info

Product

Resources

About