Psychoemotional factors and their influence on the quality of life in patients with GERD

Hill, Charles E.; Versluijs, Yvonne; Furay, Elisa; Reese-White, Deonna; Holan, Cole; Alexander, Jeremiah; Doggett, Stephanie; Ring, David; Buckley, F. Paul

doi:10.1007/s00464-020-08145-8

Cited by 10 publications

(20 citation statements)

References 43 publications

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“…Bivariate analysis revealed a link between QoL and gender, occupational status, and education level. Males presented a higher mean RQS score than females, in contrast to the work of Hill et al (2021). A negative correlation was found between QoL and age as well as the total number of typical and atypical symptoms for each patient, similarly shown in a study of Awada et al (2014).…”

Section: Discussionsupporting

confidence: 71%

Reflux-Qual-Short-Form Questionnaire: Translation and Validation of the Greek Version

Georganta

Koreli

Mantoudi

et al. 2022

Gastroenterology Nursing

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The aim of this study was the translation and validation of the Reflux-Qual Short-Form (RQS), a quality of life questionnaire in a Greek sample of 148 individuals with gastroesophageal reflux disease (GERD). This tool through eight items explores the effects of GERD in five dimensions of quality of life: daily activity, well-being, psychological impact, sleep, and eating. Exploratory factor analysis yielded a one-factor scale for the Greek-translated version. Internal consistency reliability of the questionnaire was deemed very satisfactory based on Cronbach's alpha coefficient, which was equal to 0.816. Split-half reliability was evaluated as an additional measure of internal consistency. The test–retest reliability analysis revealed a good stability after a 1-month interval. Construct validity was measured by the correlation level between each item and the adjusted global score, resulting in an acceptable level of convergence between the items. Concurrent validity was confirmed using the 36-Item Short Form Health Survey (SF-36) as a reference scale. This study indicates that RQS Questionnaire is a short, simple, reliable, and valid tool that can be used to assess quality of life in Greek individuals with GERD.

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Section: Discussionsupporting

confidence: 71%

Reflux-Qual-Short-Form Questionnaire: Translation and Validation of the Greek Version

Georganta

Koreli

Mantoudi

et al. 2022

Gastroenterology Nursing

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show abstract

“…Therefore, only the prevalence value of the examined symptoms could be given and there was no data to state whether symptoms were caused by GERD (acidic/weakly acidic/non-acidic reflux) or functional disease (e.g., functional heartburn). In this study, the lack of RSI score is a limitation, which is mainly used for LPR but can be also performed for GERD patients for an evaluation of the symptoms [ 35 , 36 ]. Patients with OSA and / or obesity were not observed in our study because there were no questions for sleeping disorder in the questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of reflux-related symptoms in South-Hungarian blood donor volunteers

et al. 2022

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Background/Aim Population-based studies on the prevalence of GERD-related symptoms are still missing in Eastern Europe, therefore, we aimed to obtain such data in South-East Hungarian subjects. Methods A total of 2,002 apparently healthy blood donor volunteers were consecutively enrolled and completed detailed questionnaires related to general factors, demographic data, socioeconomical factors, and the presence and frequency of typical and atypical GERD-related symptoms. Results Among 2,002 study participants, 56.5% were completely asymptomatic. The prevalence of typical GERD symptoms appearing at least monthly or weekly was 16.5% and 6.8%, respectively. Two-thirds (209/330) of the patients experienced at least monthly occurring typical GERD symptoms and also had associated atypical symptoms and this was even more pronounced when comparing subgroups with higher symptom frequencies. Significant correlations were found between monthly GERD-related complaints and height, body mass index (BMI), coffee consumption, and smoking. Positive family history was another significant factor in all the symptom-frequency categories. GERD-related symptom frequency showed a linear association with sex (R2 = 0.75, P = 0.0049). Typical and atypical GERD symptoms were significantly more common in those with chronic diseases than those without. Heartburn was observed in 12.5% and 4.4% (P<0.05) and acid regurgitation was seen in 6.9% and 1.8% (P<0.05), respectively. Conclusion The prevalence of GERD-related symptoms in South Hungary was significantly lower than that in Western countries and was closer to Eastern values. The presence of mild, non-exclusionary chronic diseases significantly increased the prevalence of GERD-related symptoms, as well as positive family history of GERD, height, BMI, coffee consumption, and smoking.

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“…In addition to acid-induced esophageal mucosal damage, mental disorders such as anxiety and depression have been documented to exert a crucial role in the pathogenesis of GERD. Current evidence suggests that patients with anxiety and depression still suffer from symptoms after acid suppression, with no significant improvement in their quality of life [6,7]. erefore, there is an urgent demand for drugs with satisfying efficacy and low side effects.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-Based Exploration of the Mechanism of Action of Shugan Hewei Recipe in the Treatment of Gastroesophageal Reflux Disease with Anxiety and Depression

Liu

Zhang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The Shugan Hewei recipe (SHR) is a well-recognized traditional Chinese medicine (TCM) prescription that has been shown to significantly improve chest pain, acid regurgitation, and the mood of GERD. Nonetheless, the underlying mechanisms remain unclear. In this study, the active compounds and targets of SHR were predicted using network pharmacology. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were utilized to explore the therapeutic mechanism of SHR. Combined with the drug target obtained from network pharmacology, the therapeutic effect and mechanism of SHR were observed. SHR’s main active compounds included quercetin, kaempferol, and luteolin. The core targets of SHR and GERD were TGF-β1, IL-1β, IL-4, CXCL10, MAPK1, MAPK3, CXCL8, IL-10, IL-2, and FOS, involving virus infection, inflammatory response, and body immunity. The core targets of SHR during the treatment of mental disorders were GABRA1, GABRA2, GABRA3, GABRA5, and GABRA6, involving synaptic transmission and transmembrane movement. Animal experiments revealed that SHR could repair the lower esophageal mucosa, mediate inflammatory factors, and GABA receptors and improve the behavior of rats. Overall, our results substantiate that SHR has huge prospects for widespread application in treating GERD subjects with anxiety and depression.

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Psychoemotional factors and their influence on the quality of life in patients with GERD

Cited by 10 publications

References 43 publications

Reflux-Qual-Short-Form Questionnaire: Translation and Validation of the Greek Version

Reflux-Qual-Short-Form Questionnaire: Translation and Validation of the Greek Version

Prevalence of reflux-related symptoms in South-Hungarian blood donor volunteers

Network Pharmacology-Based Exploration of the Mechanism of Action of Shugan Hewei Recipe in the Treatment of Gastroesophageal Reflux Disease with Anxiety and Depression

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