Psychoendocrine Response to Sexual Arousal in Human Males

LaFerla, John J.; Anderson, Donald L.; Schalch, Don S.

doi:10.1097/00006842-197803000-00007

Cited by 67 publications

(17 citation statements)

References 8 publications

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“…Such anticipatory or preparatory sex hormone responses are suggested by several other studies [3,25,31] and seem to re¯ect more general appetitive responses in the expectation of the potentially rewarding consequences of sexual activity. As appetitive responses are behaviors that represent a central motivational state for contact with a goal object [2], increased testosterone concentrations may represent an enhancement of the aective properties of the goal object by sexual abstinence.…”

Section: Discussionmentioning

confidence: 56%

Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence

Exton¹,

Krüger²,

Bursch

et al. 2001

World Journal of Urology

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This current study examined the effect of a 3-week period of sexual abstinence on the neuroendocrine response to masturbation-induced orgasm. Hormonal and cardiovascular parameters were examined in ten healthy adult men during sexual arousal and masturbation-induced orgasm. Blood was drawn continuously and cardiovascular parameters were constantly monitored. This procedure was conducted for each participant twice, both before and after a 3-week period of sexual abstinence. Plasma was subsequently analysed for concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone and testosterone concentrations. Orgasm increased blood pressure, heart rate, plasma catecholamines and prolactin. These effects were observed both before and after sexual abstinence. In contrast, although plasma testosterone was unaltered by orgasm, higher testosterone concentrations were observed following the period of abstinence. These data demonstrate that acute abstinence does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males.

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Section: Discussionmentioning

confidence: 56%

Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence

Exton¹,

Krüger²,

Bursch

et al. 2001

World Journal of Urology

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“…The significant correlations between increases in LH and plasma nicotine and plasma cocaine levels suggest that LH may contribute to the abuse-related effects of both drugs (for review, see Mello and Mendelson, 2002). In young men, LH increases were temporally related to behavioral and physiological measures of sexual arousal (La Ferla et al, 1978). LH is essential for normal reproductive function (Yen et al, 1999), and high LH levels during the periovulatory phase in females may also be associated with increased sexual receptivity .…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravenous Cocaine and Cigarette Smoking on Luteinizing Hormone, Testosterone, and Prolactin in Men

Mendelson

Sholar²,

Mutschler³

et al. 2003

J Pharmacol Exp Ther

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Cocaine and nicotine have a number of similar behavioral and neurobiological effects. This study compared the acute effects of cocaine and cigarette smoking on luteinizing hormone (LH), testosterone (T), and prolactin. Twenty-four men who met American Psychiatric Association Diagnostic and Statistical Manual criteria for cocaine abuse or nicotine dependence were given intravenous cocaine (0.4 mg/kg) or placebo-cocaine, or smoked a low or high nicotine cigarette under controlled conditions. Placebo-cocaine or low nicotine cigarette smoking did not change LH, T, or prolactin. Peak plasma levels of 254 Ϯ 18 ng cocaine/ml and 22.6 Ϯ 3.4 ng nicotine/ml were measured at 8 and 14 min, respectively. LH increased significantly after both i.v. cocaine and high nicotine cigarette smoking (P Ͻ 0.01). These LH increases were significantly correlated with increases in cocaine and nicotine plasma levels (P Ͻ 0.001-0.003), and high nicotine cigarette smoking stimulated significantly greater increases in LH release than i.v. cocaine (P Ͻ 0.05). Testosterone levels did not change significantly after either cocaine or after high nicotine cigarette smoking. After i.v. cocaine, prolactin decreased significantly and remained below baseline levels throughout the sampling period (P Ͻ 0.05-0.01). After high nicotine cigarette smoking, prolactin increased to hyperprolactinemic levels within 6 min and remained significantly above baseline levels for 42 min (P Ͻ 0.05-0.03). The rapid increases in LH and reports of subjective "high" after both i.v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects.

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“…The Dis scale revealed the highest correlation with TT as compared to the other subscales of the SSS [4,24]. Laferla et al [25] found that the magnitude of LH response was positively correlated with the subjective evaluation of sexual arousal. The FSH showed results in the same direction.…”

Section: Introductionmentioning

confidence: 99%

Sensation Seeking, Sexual Curiosity and Testosterone in Inmates

Aluja

Garcı́a²

2005

Neuropsychobiology

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The relationships between sensation seeking, curiosity about sex, and total and free testosterone in inmates were investigated. The role of other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in these relationships was also analyzed. Previous analysis allowed the deletion of extreme hormone values affecting the distribution of the variables. In spite of obtaining a high mean for SHBG, relationships between hormones were appropriate. It was observed that higher values of SHBG produce an increment in total testosterone, but not in free testosterone. Positive relationships between total testosterone and the Disinhibition scale of the Sensation Seeking Scale Form V were replicated, although they were affected by SHBG. Significant relationships between total and free testosterone and curiosity about sex were also found. LH and FSH did not influence these patterns of relations. It was suggested that relationships between SHBG and sensation seeking in inmates could be mediated by items referring to alcohol and drugs. The high levels of SHBG observed in the sample reinforced this suggestion. In spite of the role of SHBG, subjects who were desinhibited and concerned about sex presented higher concentrations of total and free testosterone. The results support Zuckerman’s sensation seeking theory.

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Psychoendocrine Response to Sexual Arousal in Human Males

Cited by 67 publications

References 8 publications

Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence

Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence

Effects of Intravenous Cocaine and Cigarette Smoking on Luteinizing Hormone, Testosterone, and Prolactin in Men

Sensation Seeking, Sexual Curiosity and Testosterone in Inmates

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