Psychogenic polydipsia and water intoxication—Concepts that have failed

Vieweg, W. Victor R.; David, J. J.; Rowe, W. T.; Peach, Michael J.; Veldhuis, J. D.; Kaiser, Donald L.; Spradlin, Wilford W.

doi:10.1016/0006-3223(85)90116-7

Cited by 63 publications

(20 citation statements)

References 70 publications

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“…In the present study, we have no documented data on the water metabolism in our patients; however, a syn drome of hyponatremia due to water retention, very sim ilar to the syndrome of inappropriate antidiuretic hor mone (ADH) secretion, has been described in psychiatric patients (PIP syndrome) [26].…”

Section: Discussionmentioning

confidence: 71%

Increased Basal Plasma Vasopressin-Neurophysin in Mania

Legros

Ansseau²

1989

Horm Res

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Basal plasma vasopressin-neurophysin (hN_pI) was estimated in 50 drug-free neuropsychiatric patients classified according to the Research Diagnostic Criteria. The hN_pI concentration was higher in the 5 manics (0.76 ± 0.15 ng/ml) than in the 16 schizophrenics (0.53 ± 0.08), 12 minor depressed (0.54 ± 0.06) and 17 major depressed (0.48 ± 0.10; p < 0.05). Thus, those results confirm our initial observation of an increased vasopressinergic function in the manic compared to the depressed phase in one bipolar patient. Whether this increase in the vasopressin release is a consequence of the neuropsychiatric disorders or initiates and/or participates in their pathophysiology remains to be elucidated. The hypothetic consequence on water metabolism of such an increase remains also to be defined.

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Section: Discussionmentioning

confidence: 71%

Increased Basal Plasma Vasopressin-Neurophysin in Mania

Legros

Ansseau²

1989

Horm Res

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“…Recent research in water metabolism and psychosis has moved us beyond the concept of psychogenic (nonorganic) polydipsia [14] to explain water intoxication among psychiatric patients. We and Goldman et al [18] have shown disturbances in fluid intake and osmotic reg ulation among chronically psychotic patients subject to water intoxication [15][16][17][18].…”

Section: Water Metabolism In Psychosismentioning

confidence: 99%

Abnormal Diurnal Weight Gain in Chronic Psychosis without Seasonal Change

Vieweg

Godleski²,

Pavalonis³

et al. 1988

Neuropsychobiology

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We found diurnal weight gain to be abnormal in chronic psychosis. Nineteen chronically psychotic patients were weighed daily at 7 a.m. and 4 p.m. for 1 year. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and then dividing the result by the 7 a.m. weight. NDWG was 2.714 ± 0.824% for the 19 study patients, 0.631 ± 0.405% for 16 acutely psychotic controls and 0.511 ± 0.351 % for 29 normals. All the study patients had NDWG values above the upper limit of normal. There were no seasonal differences (p < 0.0001) in NDWG of the study sample. Sex, diagnoses, vital signs, and drugs did not explain our findings.

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“…Vieweg et al (1985) described the clinical features of patients with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome). The PIP syndrome appears mainly in deteriorated, chronic schizophrenics (Vieweg et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Tardive dyskinesia correlates inversely with polydipsia in chronic psychiatric patients

Nishikawa

Katayanagi

Tsuda

et al. 1998

Hum. Psychopharmacol. Clin. Exp.

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The present study was undertaken to investigate the relationship between tardive dyskinesia (TD) and polydipsia. The Abnormal Involuntary Movement Scale (AIMS) and percent of maximum weight gain (PMWG)/week were simultaneously examined in 163 hospitalized patients receiving neuroleptic treatment. Patients with TD were less polydipsic than patients without TD. Moreover, there was a weak but signi®cant negative correlation between the AIMS total scores and PMWG. The AIMS total scores were correlated signi®cantly with age at onset of disease, whereas PMWG was negatively correlated with age at disease onset. The present study is the ®rst report to clarify the relationship between TD and polydipsia utilizing continuous data of both TD and polydipsia. The biological bases of the dierence between TD and polydipsia were discussed in term of supersensitivity of dopaminergic and noradrenergic neurons. #

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Psychogenic polydipsia and water intoxication—Concepts that have failed

Cited by 63 publications

References 70 publications

Increased Basal Plasma Vasopressin-Neurophysin in Mania

Increased Basal Plasma Vasopressin-Neurophysin in Mania

Abnormal Diurnal Weight Gain in Chronic Psychosis without Seasonal Change

Tardive dyskinesia correlates inversely with polydipsia in chronic psychiatric patients

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