Psychogeriatric Inventory of Disconcerting Symptoms and Syndromes (PGI-DSS): validity and reliability of a new brief scale compared to the Neuropsychiatric Inventory for Nursing Homes (NPI-NH)

Monfort, Jean-Claude; Lezy, Anne-Marie; Papin, A.; Montcel, Sophie Tezenas du

doi:10.1017/s1041610220000496

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…Surprisingly, IVIG group performed the worst in NPI scale, which is often used to evaluate the neurological and mental status of the elderly with dementia, suggesting IVIG deteriorated behavioral and psychological symptoms of AD patients [ 49 ]. A possible explanation is that IVIG decreased CSF Aβ levels quickly [ 23 ], which is proven to be related to an increase in neuropsychiatric symptoms [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of blood derivatives therapy in Alzheimer’s disease: a systematic review and meta-analysis

et al. 2022

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Background Blood derivatives therapy is a conventional clinical treatment, while the treatment for Alzheimer’s disease (AD) is relatively novel. To provide clinical references for treating AD, this meta-analysis was performed to evaluate the efficacy and safety of blood derivatives therapy on the patients with AD. Methods A systematic articles search was performed for eligible studies published up to December 6, 2021 through the PubMed, Embase, Cochrane library, ClinicalTrials.gov, Chinese National Knowledge Infrastructure database, and Wanfang databases. The included articles were screened by using rigorous inclusion and exclusion criteria. Study selection and data-extraction were performed by two authors independently. Random effects model or fixed effects model was used. Quality of studies and risk of bias were evaluated according to the Cochrane risk of bias tool. All analyses were conducted using Review Manager 5.4. The study was designed and conducted according to the Preferring Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Results A total of three plasma administrations (two plasma exchange and one young plasma infusion) and five intravenous immunoglobulin (IVIG) randomized controlled trials with a sample size of 1148 subjects diagnosed with AD were included. There was no significant difference in cognitive improvement and all-cause discontinuation between intervention and placebo groups (RR 1.10, 95% CI 0.79–1.54). And Intervention groups showed not a statistically significant improvement in cognition of included subjects measured by the ADAS-Cog (MD 0.36, 95% CI 0.87–1.59), ADCS-ADL (MD −1.34, 95% CI − 5.01–2.32) and NPI (MD 2.20, 95% CI 0.07–4.32) score compared to the control groups. IVIG is well tolerated for AD patients even under the maximum dose (0.4 g/kg), but it is inferior to placebo in Neuropsychiatric Inventory scale in AD patients (MD 2.19, 95% CI 0.02–4.37). Conclusions The benefits of blood derivatives therapy for AD are limited. It is necessary to perform well-designed randomized controlled trials with large sample sizes focusing on the appropriate blood derivatives for the specific AD sub-populations in the future. Systematic review registration PROSPERO CRD42021233886

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of blood derivatives therapy in Alzheimer’s disease: a systematic review and meta-analysis

et al. 2022

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“…IVIG group performed the worst in NPI scores, which is often used to evaluate the neurological and mental status of the elderly with dementia, suggesting IVIG deteriorated behavioral and psychological symptoms of AD patients [57]. A possible explanation is that IVIG decreased CSF Aβ levels quickly [23], which is proven to be related to an increase in neuropsychiatric symptoms [58].…”

Section: Discussionmentioning

confidence: 99%

Efficacy And Safety of Blood Derivatives Therapy in Alzheimer’s Disease: A Systematic Review And Meta-Analysis

Fei

Pan

Pei

et al. 2021

Preprint

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Objective: Blood derivatives therapy is a conventional clinical treatment, while the treatment for Alzheimer’s disease (AD) is relatively novel. To provide clinical references for treating AD, this meta-analysis was performed to evaluate the efficacy and safety of blood derivatives therapy on the patients with AD. Methods: A systematic articles search was performed for eligible studies published up to December 6, 2021 through the PubMed, Embase, Cochrane library, ClinicalTrials.gov, Chinese National Knowledge Infrastructure database and Wanfang databases. The included articles were screened by using rigorous inclusion and exclusion criteria. Random effects model was used for this meta-analysis when there is heterogeneity, or else fixed effects model was used. Quality of studies and risk of bias were evaluated.Results: A total of 3 plasma administrations (2 plasma exchange and 1 young plasma infusion) and 5 intravenous immunoglobulin (IVIG) randomized controlled trials with a sample size of 1148 subjects diagnosed with AD were included. There was no significant difference in cognitive improvement and all-cause discontinuation between intervention and placebo groups. In subgroup analysis, plasma administration was superior to placebo only in limited studies for individual scales. IVIG is well tolerated for AD patients even under the maximum dose (0.4g/kg), but it’s inferior to placebo in Neuropsychiatric Inventory scale in AD patients (P =0.05).Conclusions: The benefits of blood derivatives therapy for AD are limited. It’s necessary to perform well-designed randomized controlled trials with large sample sizes focusing on the appropriate blood derivatives for the specific AD sub-populations in the future. Systematic review registration: PROSPERO CRD42021233886.

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“…Monsieur D. est typiquement un patient déconcertant [17] , [18] qui risque de faire basculer Madame S. dans l’épuisement professionnel [19] .…”

Section: à Propos De L’épreuve…unclassified

Éthique de la sollicitude dans une unité cognitivo-comportementale : des « proofs of care » aux « outils pour le care »

Bailleul

Marie-Bailleul²

2021

NPG Neurologie - Psychiatrie - Gériatrie

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Psychogeriatric Inventory of Disconcerting Symptoms and Syndromes (PGI-DSS): validity and reliability of a new brief scale compared to the Neuropsychiatric Inventory for Nursing Homes (NPI-NH)

Cited by 7 publications

References 43 publications

Efficacy and safety of blood derivatives therapy in Alzheimer’s disease: a systematic review and meta-analysis

Efficacy and safety of blood derivatives therapy in Alzheimer’s disease: a systematic review and meta-analysis

Efficacy And Safety of Blood Derivatives Therapy in Alzheimer’s Disease: A Systematic Review And Meta-Analysis

Éthique de la sollicitude dans une unité cognitivo-comportementale : des « proofs of care » aux « outils pour le care »

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