Introduction: The contemporary surge in sports participation, from recreational to professional levels, has brought forth an undeniable enthusiasm for physical activity. However, this heightened engagement comes with an inherent risk of sports-related injuries, spanning various nature and severity. This article introduces the imperative need for a systematic and practical approach to prevent sports injuries, emphasizing the age-diverse demographic involved and the multifaceted motivations driving sports participation. Materials and Methods: The “Rule of 10,” presented in this paper, serves as a comprehensive guideline for sports injury prevention. The methodology encompasses a range of proactive measures addressing pre-season preparation, athlete education, and holistic strategies to mitigate injury risks. Each facet of the rule, from pre-season physical check-ups to emphasizing psychological preparedness, contributes to a cohesive and multifaceted injury prevention framework. Conclusion: We through our review article have focused on the “Rule of 10” which advocates a holistic approach to sports injury prevention, integrating pre-season assessments, diverse training, and technology. It emphasizes resilience, education, and collective responsibility for athlete well-being. Keywords: Agility, Endurance, Prevention, Sports, Strength.