Psychological and emotional concomitants of infertility diagnosis in women with diminished ovarian reserve or anatomical cause of infertility

Nicoloro-SantaBarbara, Jennifer; Lobel, Marci; Bocca, Silvina; Stelling, J.; Pastore, Lisa M.

doi:10.1016/j.fertnstert.2017.05.008

Cited by 31 publications

(21 citation statements)

References 41 publications

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“…Low economic income and educational level will also have negative effects on the mental health of infertile patients receiving IVF-ET [5]. The pressure level of infertile female patients due to decreased ovarian reserve function (DOR) is higher than that of infertile females due to other causes [21], which is consistent with the results of this study.…”

Section: Discussionsupporting

confidence: 84%

Quantitative and Qualitative Analyses of Psychological Experience and Adjustment of In Vitro Fertilization-Embryo Transfer Patients

et al. 2019

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BackgroundThe aim of this study was to quantitatively analyze the psychosocial characteristics of in vitro fertilization-embryo transfer (IVF-ET) couples and normal couples, and to identify the influencing factors of psychological characteristics and pregnancy outcomes.Material/MethodsThere were 260 infertile couples undergoing IVF-ET and 277 healthy couples of childbearing age in Shengjing Hospital of China Medical University recruited into 2 groups. Psychosocial characteristics were compared to analyze the influencing factors of pregnancy outcomes after IVF-ET. In-depth interviews (n=11) and infertility-related forum posts (n=12) were adopted to obtain the data related to the psychological experience and adjustment. Nvivo 11 software was utilized to collect and analyze the data.ResultsThe levels of anxiety and depression in the IVF-ET group were significantly higher (both P<0.01), the total scores of marital quality scale and social support scale were significantly lower (both P<0.05), immature defense mechanism score was significantly higher (P<0.05), and mature defense mechanism score (P<0.05) was significantly lower than those in the control group. Bod mass index (BMI), family’s rural residence, marital quality, and immature and mature defense mechanisms were influencing factors of depression in IVF-ET female patients (all P<0.05). Marital quality, mature and immature defense mechanisms, concealment factors, and Harm Avoidance (HA) score were influencing factors of depression in IVF-ET males (all P<0.05). The age of the female patient was an independent influencing factor of IVF-ET pregnancy success rate (P<0.01).ConclusionsThe mental health levels of IVF-ET patients were worse than those of fertile couples. The younger the female infertile patient, the higher pregnancy rate of IVF-ET.

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Section: Discussionsupporting

confidence: 84%

Quantitative and Qualitative Analyses of Psychological Experience and Adjustment of In Vitro Fertilization-Embryo Transfer Patients

et al. 2019

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“…The emotional response to infertility and especially assisted reproductive technology (ART) are anxiety and depression [9]. Anxiety levels of infertile women may vary with age, cause of infertility, duration of infertility, socioeconomic status and some other unexpected stressors like outbreaks [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The level of anxiety in infertile women whose ART cycles are postponed due to the COVID-19 outbreak

Tokgöz

Kaya

Tekin

2020

Journal of Psychosomatic Obstetrics & Gynecology

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Aim: This study evaluated the level of fear and anxiety related to the COVID-19 outbreak, in infertile women whose ART cycles were delayed due to the pandemic. Materials and methods: An online survey was sent to women whose ART cycles were postponed due to the COVID-19 outbreak between April and May 2020. The study population were 101 participants. The main outcome measure is to determine the levels of fear and anxiety in infertile women by using the Spielberger State-Trait Anxiety Inventory (STAI-T and STAI-S) and Fear of COVID-19 scale . The relationship of the COVID-19 outbreak with the willingness to go ahead with the desire for pregnancy was also assessed. Results: The state-anxiety levels were significantly higher in women above 35 years (45.0 ± 5.2 vs. 42.2 ± 4.5, p ¼ 0.006). Women with diminished ovarian reserve had a higher state-anxiety compared to other causes, but were not found to be significant (44.7 ± 5.2 vs. 42.5 ± 5.0, p ¼ 0.173). Women who thought that the possibility of not being able to get pregnant was more important than being infected with the COVID-19 had higher anxiety levels than women who thought just the opposite. The diminished ovarian reserve and high duration of infertility were found to be significantly associated with higher anxiety levels (OR ¼ 2.5, p < 0.05). The diminished ovarian reserve and previous ART failure significantly predicted the presence of clinical state-anxiety. Conclusion:The state-anxiety was found to be higher in women whose cycles were postponed due to the outbreak and the presence of diminished ovarian reserve also significantly affected anxiety levels. Further research is needed to assess whether COVID-19 will have any impact on ART treatments in the next few years.

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“…The etiology and pathogenesis of DOR remain unclear so far, but it has been reported that DOR may be related to age (Fan et al, 2019), immunity (Silva et al, 2014), heredity, environment, radiotherapy and chemotherapy (Smith et al, 2013), surgery, psychological stress (Nicoloro-SantaBarbara et al, 2017), and infectious factors (Soylu Karapinar et al, 2017). A prospective cohort study found that poor ovarian response was related to age and apoptosis of ovarian granulosa cells (Fan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies found that chemical substances such as parabens might be related to DOR (Smith et al, 2013). Long-term anxiety could cause dysfunction of the hypothalamic-pituitary-ovarian axis (HPOA), which can lead to DOR or premature ovarian failure (Nicoloro-SantaBarbara et al, 2017). Among these factors, alkylating chemotherapy agents, such as cyclophosphamide (CTX), which is highly gonad-toxic, led to a decrease in ovarian function and in anti-Müllerian hormone (AMH) (Ben-Aharon et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

et al. 2020

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Backgrounds: Diminished ovarian reserve (DOR) contributes significantly to female infertility. Bushen Cuyun Recipe (BCR, Tradename Yueliang Yin), a product marketed in China, has shown effects in the treatment of female infertility in clinical practices of traditional Chinese medicine (TCM). In this study, we aimed to investigate the chemical compositions of BCR and its efficacy based on scientific evidence and pharmacological mechanisms in DOR treatments. Methods: The chemical compositions of BCR were determined by the UHPLC-LTQ-Orbitrap MS method. DOR was induced in a rat model by intraperitoneal injection of cyclophosphamide (CTX) 90 mg/kg once. After the CTX treatment for 14 days, rats were intragastrically administrated deionized water, dehydroepiandrosterone (DHEA), or BCR in low, middle, and high doses for 30 days. Ovarian index, ovarian morphology, follicle number, and anti-Müllerian hormone (AMH) in serum were determined to assess the effects of BCR. To investigate possible action mechanisms, network pharmacological analysis was used to predict possible pathways in the effects of BCR on female infertility. In experimental studies, the contents of hormones in the hypothalamic-pituitary-ovarian axis (HPOA, including estradiol (E 2), follicle-stimulating hormone (FSH), and gonadotropinreleasing hormone (GnRH)) and pyroptosis-related proteins, including gasdermin D (GSDMD), caspase-1, and interleukin-18 (IL-18), in ovarian were detected by ELISA, immunofluorescence and Western blot. Results: Chemical studies revealed a total 84 components in BCR, which included 43 flavonoids, 13 triterpenoids, 11 phenolic acids, 8 alkaloids, 1 coumarin, 1 anthraquinone, and 7 other components. After treatments with BCR, the ovarian morphology, ovarian index, estrous cycle, growing follicles and corpus luteum from last ovulation, and serum AMH in DOR rats were significantly improved. Network pharmacological analysis suggested that the NOD-like receptor signaling pathway ranked No. 1 among the mechanisms by which BCR affects female infertility. Experimental results demonstrated

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Psychological and emotional concomitants of infertility diagnosis in women with diminished ovarian reserve or anatomical cause of infertility

Cited by 31 publications

References 41 publications

Quantitative and Qualitative Analyses of Psychological Experience and Adjustment of In Vitro Fertilization-Embryo Transfer Patients

Quantitative and Qualitative Analyses of Psychological Experience and Adjustment of In Vitro Fertilization-Embryo Transfer Patients

The level of anxiety in infertile women whose ART cycles are postponed due to the COVID-19 outbreak

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

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