Objective:To evaluate the effect of continuous positive airway pressure (CPAP) therapy on Ménière's disease patients with concomitant obstructive sleep apnea syndrome (OSAS), since recent reports suggest OSAS may cause dysfunction of the vestibular system. Study Design: Prospective study using CPAP administered to patients diagnosed with "Defi nite Ménière's disease" according to the guidelines of the American Academy of OtolaryngologyHead and Neck Surgery and combined with OSAS. Pathologically, Ménière's disease is associated with hydropic distension of the endolymphatic system, but the etiology of such hydrops remains unknown. Episodes of vertigo, which are often accompanied by nausea and vomiting, are the most prominent and disabling features of the disease. The presentation of Ménière's disease is highly variable, and its clinical course is characterized by acute exacerbation and spontaneous remission. [2][3][4] It is well known that insomnia is associated with increased psychological symptomatology and perceived stress, higher predisposition to arousal, and greater impairments to quality of health. [5][6][7] The relationship between Ménière's disease and stress is well documented, but that between Ménière's disease and insomnia is unclear. In our previous report, 8 we fi rst found
BRIEF SUMMARYCurrent Knowledge/Study Rationale: Recent reports indicate that OSAS may cause vestibular dysfunction. The current study was designed to determine whether treatment of patients with Ménière's disease and concomitant OSAS using CPAP ameliorate the manifestations of Ménière's disease.