Background: Family caregivers of patients with COVID-19 face many challenges that affect their physical and mental health. Aim: The aim of the present study was to explore the family caregivers' experiences of caring for patients with COVID-19. Methods: This qualitative phenomenological study was performed based on 13 family caregivers who had experience in home caring for patients with COVID-19. Data were collected through purposive sampling with in-depth semi-structured interviews. The Colaizzi's 7-step method was used to determine themes. The MAXQDA10 software was used to manage qualitative data analysis.Results: Five themes of (a) “nature of the disease” with 2 subcategories, including “fluctuating symptoms” and “emergent and unpredictable disease;” (b) “unmet needs” with 3 subcategories, including “lack of knowledge,” “lack of health facilities,” and” financial problems;” (c) “unpleasant physical, psychological, and social experiences” with 3 subcategories, including “unpleasant physical experiences,” “unpleasant psychological experiences,” and “unpleasant social experiences;” (d) “care facilitators” with 3 subcategories, including “social support,” “adaptive mechanisms,” and “intrinsic motivations;” and (e) “positive experiences” with 3 subcategories, including “promoting spirituality,” “improving relationships,” and “growth” were extracted.Conclusion: Information and financial support for COVID-19 should be provided to family caregivers. Also, community members should embrace patients and family caregivers and reinforce the positive experiences of caregivers.