Psychological assessment of patients with premature ovarian failure

Taraciuk, M; Nolting, Manuel; Fernandez, Georgianna; Colela, Daniela; Onetto, Claudia; Straminsky, Vanesa

doi:10.1080/09513590701668866

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…The results indicated that female mice subjected to ovary irradiation exhibited significantly increased levels of anxiety. These observations were similar to the symptoms observed in patients with POF ( 46 ). Previous studies have shown that radiation can cause mood changes in animals ( 44 ).…”

Section: Discussionsupporting

confidence: 89%

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

et al. 2022

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Radiological therapy/examination is the primary source of artificial radiation exposure in humans. While its application has contributed to major advances in disease diagnosis and treatment, ionizing radiation exposure is associated with ovarian damage. The use of natural products, either alone or as an adjunct, has become increasingly common for reducing the side effects of radiological therapy during disease treatment. Herein, we explored the protective effect of folic acid (FA), a widely used B vitamin, against radiation-induced ovarian injury and its mechanism of action. Female mice with normal ovarian function were randomly divided into control, FA, radiation, and radiation + FA groups. The intervention strategy included daily intragastric administration of FA (5 mg/kg) for 3 weeks prior to radiation exposure. Mice in the radiation and radiation + FA groups received a single dose of 5 Gy X-ray irradiation. Changes in the estrous cycle were then recorded, and ovarian tissues were collected. Pathophysiological changes as well as reproductive and endocrine-related indexes were determined via H&E staining, immunohistochemistry, Western blot, and ELISA. The reproductive performance and emotional symptoms of animals were also monitored. Our results indicated that FA intervention effectively alleviated ovarian damage, leading to more regular estrous cycles, lesser impairment of follicular morphology and endocrine status, as well as greater germ cell preservation. Reduced levels of oxidative stress, inflammation, and enhanced DNA repair were associated these changes. FA pre-administration improved the reproductive performance, leading to higher pregnancy rates and greater litter sizes. Further, the anxiety levels of animals were significantly reduced. Our results indicate that FA pre-administration significantly alleviates radiation-induced ovarian damage in rodents, highlighting its potential as a protective strategy against radiation exposure in the female population.

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Section: Discussionsupporting

confidence: 89%

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

et al. 2022

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“…Loss of reproductive capabilities seems to be a major upsetting element, and this does not depend on whether the patients already have children or not. Professional assistance should be offered to help patients cope with the emotional sequelae of POF [13,59].…”

Section: Emotional Support and Counselingmentioning

confidence: 99%

Premature ovarian failure from current perspective

Kökçü

2010

Gynecological Endocrinology

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Premature ovarian failure (POF) is a syndrome characterised by amenorrhoea, hypoestrogenism and hypergonadotropinism before the age of 40. It is a disorder affecting approximately 1% of women <40 years, 1/1,000 women by the age of 30 and 1/10,000 women by the age of 20. POF is not merely an early menopause. Up to 50% of the patients with POF will have intermittent and unpredictable ovarian function which may persist for some years. Heterogeneity of POF is also reflected by the variety of possible causes, including autoimmunity, toxics, drugs, radiation, infectious as well as genetic defects. HRT remains the cornerstone of treatment and the only proven method of achieving pregnancy in these patients is by ovum donation.

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“…Anxiety symptoms have been found in premature ovarian failure and psychosocial stress has scored higher during the year before cessation of menses. 63 …”

Section: Considerationsmentioning

confidence: 99%

Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination

Little¹,

Ward

2014

Journal of Investigative Medicine High Impact Case Reports

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Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV) vaccination presented to a general practitioner in rural New South Wales, Australia. The unrelated girls were aged 16, 16, and 18 years at diagnosis. Each had received HPV vaccinations prior to the onset of ovarian decline. Vaccinations had been administered in different regions of the state of New South Wales and the 3 girls lived in different towns in that state. Each had been prescribed the oral contraceptive pill to treat menstrual cycle abnormalities prior to investigation and diagnosis. Vaccine research does not present an ovary histology report of tested rats but does present a testicular histology report. Enduring ovarian capacity and duration of function following vaccination is unresearched in preclinical studies, clinical and postlicensure studies. Postmarketing surveillance does not accurately represent diagnoses in adverse event notifications and can neither represent unnotified cases nor compare incident statistics with vaccine course administration rates. The potential significance of a case series of adolescents with idiopathic premature ovarian insufficiency following HPV vaccination presenting to a general practice warrants further research. Preservation of reproductive health is a primary concern in the recipient target group. Since this group includes all prepubertal and pubertal young women, demonstration of ongoing, uncompromised safety for the ovary is urgently required. This matter needs to be resolved for the purposes of population health and public vaccine confidence.

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Psychological assessment of patients with premature ovarian failure

Cited by 17 publications

References 6 publications

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice

Premature ovarian failure from current perspective

Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination

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