Psychological Burden in the Era of Haart: Impact of Selenium Therapy

Shor‐Posner, Gail; Lecusay, Robert; Miguez, Maria-Jose; Moreno‐Black, Geraldine; Zhang, Guoyan; Rodríguez, Nohra Cecilia; Burbano, Ximena; Baum, Marianna K.; Wilkie, Frances L.

doi:10.2190/pffd-d920-v041-n5kd

Cited by 49 publications

(38 citation statements)

References 32 publications

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“…This study, however, failed to correlate mood to serum selenium status [38,39] . Patients with HIV/AIDS, treated with selenium therapy in a placebo-controlled doubleblinded trial, found that at 12 months the participants who had received selenium, reported increased vigour and less anxiety, compared to the placebo-treated individuals, although there was no apparent effect of selenium on either distress or depression [40] .…”

Section: Selenium and Moodmentioning

confidence: 99%

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

et al. 2008

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One third of older people in nursing and/or residential homes have significant symptoms of depression. In younger people, deficiencies in selenium, vitamin C and folate are associated with depression. This study examines the association between micronutrient status and mood before and after supplementation. The objective was to determine whether the administration of selenium, vitamin C and folate improved mood in frail elderly nursing home residents. Mood was assessed using the Hospital Anxiety and Depression rating scale (HAD), and Montgomery-Åsberg Depression Rating Scale (MADRS). Micronutrient supplementation was provided for 8 weeks in a double-blinded randomised controlled trial. Significant symptoms of depression (29%) and anxiety (24%) were found at baseline. 67% of patients had low serum concentrations of vitamin C, but no-one was below the reference range for selenium. Depression was significantly associated with selenium levels, but not with folate or vitamin C levels. No individual with a HAD depression score of ≧8, had selenium levels >1.2 µM. In those patients with higher HAD depression scores, there was a significant reduction in the score and a significant increase in serum selenium levels after 8 weeks of micronutrient supplementation. Placebo group scores were unchanged. This small study concluded that depression was associated with low levels of selenium in frail older individuals. Following 8 weeks of micronutrient supplementation, there was a significant increase in selenium levels and improved symptoms of depression occurred in a subgroup.

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Section: Selenium and Moodmentioning

confidence: 99%

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

et al. 2008

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“…As a specific example, selenium deficiency has been strongly and independently associated with disease progression and mortality in HIV-infected individuals, increased genital shedding of HIV DNA, and increased risks of fetal and child mortality as well as intrapartum mother-to-child transmission (3)(4)(5)(6). Recent studies have demonstrated that daily selenium supplementation of HIV-1 positive individuals suppresses the progression of HIV-1 viral burden, provides improvement of CD4 counts (7), increases vigor (8), decreases anxiety, and reduces the need for hospitalization when compared with those receiving a placebo (9 -11).…”

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confidence: 99%

Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages

Kalantari

Narayan

Natarajan

et al. 2008

Journal of Biological Chemistry

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Epidemiological studies suggest a correlation between severity of acquired immunodeficiency syndrome (AIDS) and selenium deficiency, indicating a protective role for this anti-oxidant during HIV infection. Here we demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase that reduces protein disulfides to free thiols, negatively regulates the activity of the HIV-1 encoded transcriptional activator, Tat, in human macrophages. We used a small interfering RNA approach as well as a high affinity substrate of TR1, ebselen, to demonstrate that Tat-dependent transcription and HIV-1 replication were significantly increased in human macrophages when TR1 activity was reduced. The increase in HIV-1 replication in TR1 small interfering RNA-treated cells was independent of the redox-sensitive transcription factor, NF-B. These studies indicate that TR-1 acts as a negative regulator of Tat-dependent transcription. Furthermore, in vitro biochemical assays with recombinant Tat protein confirmed that TR1 targets two disulfide bonds within the Cys-rich motif required for efficient HIV-1 transactivation. Increasing TR1 expression along with other selenoproteins by supplementing with selenium suggests a potential inexpensive adjuvant therapy for HIV/AIDS patients.

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“…Still, it must be noted that at the 12-month evaluation of selenium therapy in HIV-positive drug abusers, mean BDI scores were slightly lower (by 9%) in the seleniumreceiving participants, when compared to the measurements determined at the baseline visit and that of a placebo-treated group (13%) who were without influence of current drug use, antiretroviral treatment or viral load [52].…”

Section: Mean Daily Intake (μG)mentioning

confidence: 83%

Selenium and manganese in depression – preclinical and clinical studies

Sławińska

Bielecka

Iwaniak

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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According to the World Health Organization estimates, approximately 10% of the world's population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Unfortunately, the current pharmacotherapy of depressive disorders is characterized by unsatisfactory efficacy and the therapeutic effect is accompanied by many side effects. For this reason, there is still ongoing worldwide research to find new antidepressant therapies. In recent years, many data have been shown that essential elements demonstrate the antidepressant action and increase the effect of antidepressants. In this paper we present the results from the preclinical and clinical studies published over the years which show the involvement of selenium and manganese in depressive disorders. In this article, the relationship between the amount of these microelements in a diet and depression is reviewed and what's more, the association among these elements in different biomaterial and their relations to depressive symptoms is presented. Additionally, we discuss the possible influence of selenium and manganese on modulating neurotransmitter system involved in depression.

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Psychological Burden in the Era of Haart: Impact of Selenium Therapy

Abstract: Selenium therapy may be a beneficial treatment to decrease anxiety in HIV+ drug users who exhibit a high prevalence of psychological burden.

Cited by 49 publications

References 32 publications

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

Effect of Micronutrient Supplementation on Mood in Nursing Home Residents

Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages

Selenium and manganese in depression – preclinical and clinical studies

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