Psychological burden of pediatric primary immunodeficiency

Ocakoğlu, Binay Kayan; Karaca, Neslihan Edeer; Ocakoğlu, Fevzi Tuna; Erermiş, Serpil

doi:10.1111/ped.13675

Cited by 21 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected based on the general demographic patterns associated with JIA, study populations included a majority of female patients (range 52-81%) with the exception of one study. 23 Among the included pediatric studies, the mean age was 6.9 to 15.5 years and the age range in the adult studies was 18 to 73 years. Most studies did not report race and/or ethnicities.…”

Section: Population Characteristicsmentioning

confidence: 99%

“…Most studies that used validated screens for depressive symptoms reported prevalences of clinically significant symptoms in the range of 7-36% in children with JIA. [23][24][25][26]28,29,35,38,39,41,46,47 Reda et al used the MINI-KID psychiatric interview and reported that 93% of the patients had dysthymic disorder while 3% had major depressive disorder. 30 El Najjar et al found that all JIA patients scored above the cut-off for clinically significant symptoms on the CES-DC questionnaire.…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

“…31 Three studies compared JIA patients to healthy controls, of which two found that JIA patients had worse depressive symptoms. 23,35 Two additional studies reported that youth with JIA had worse anxiety/depressive symptoms than healthy controls; however, these symptoms were not analyzed separately. 41,48 The exception, Tarakci et al, did not find a significant difference between JIA patients and healthy controls in regards to depression and/or anxiety symptoms; however, they excluded JIA patients with known comorbid psychiatric diagnoses.…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

“…31 Notably, Kayan Ockagoglu et al reported that 28% of their JIA cohort had a known diagnosis of major depressive disorder. 23 From the 3 studies that evaluated adults with JIA, two noted a particularly high prevalence of either depression or anxiety symptoms. Barth et al reported a depression prevalence of 34%.…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

“…The prevalence of clinically significant symptoms of anxiety in youth with JIA ranged from 7% to 64%. 23,25,28,29,35,41,47,50 While most studies reported higher rates of depression than anxiety, a few notable studies found the opposite. 29,35,47 Most studies comparing to healthy controls found higher rates among youth with JIA.…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

See 4 more Smart Citations

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Fair

Rodriguez

Knight

et al. 2019

OARRR

View full text Add to dashboard Cite

Depression and anxiety are prevalent in children with rheumatologic diseases, including juvenile idiopathic arthritis (JIA). However, prevalence rates and the relationship with disease outcomes, including quality of life are conflicting in the early literature. To review the current literature, determine gaps in our knowledge, and identify areas in need of further investigation, we conducted a systematic review of studies examining depression and anxiety symptoms among children with JIA and the impact these symptoms may have on disease outcomes and quality of life. Six electronic databases were searched up until January 2019. Of 799 potential articles, 60 articles were included with the main focus on 28 articles from 2009 to 2019, to concentrate on the most current evidence. We found that JIA patients experience symptoms of depression and anxiety similar to other childhood chronic diseases and at higher rates than in healthy children. Patients who experience these symptoms have worse quality of life, with some evidence pointing to depression and anxiety symptoms having a greater impact on quality of life than other disease features, such as active joint count. Family members of JIA patients experience high rates of anxiety and depression symptoms which may impact their child's mental health and pain symptoms related to JIA. Conflicting reports of associations between depression/anxiety symptoms and disease features/disease outcomes and a paucity of longitudinal studies investigating the impact of treatment on mental health symptoms indicate areas in need of further research to effectively identify patients at greatest risk of depression and anxiety and to better understand how to treat and prevent these symptoms in youth with JIA. Family mental health should also be considered in investigations concerning mental health and disease outcomes of children with JIA.

show abstract

Section: Population Characteristicsmentioning

confidence: 99%

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

See 3 more Smart Citations

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Fair

Rodriguez

Knight

et al. 2019

OARRR

View full text Add to dashboard Cite

show abstract

Prevalence and risk factors of depressive symptoms in children and adolescents with juvenile idiopathic arthritis

2023

View full text Add to dashboard Cite

Depression is a serious disorder disproportionately affecting people with chronic diseases, yet, to date is rarely recognized comorbidity in pediatric rheumatology clinical routine care. The aim of this study was to investigate the prevalence of depressive symptoms and depression in children with Juvenile idiopathic arthritis (JIA) and to identify associations to risk factors. Depressive symptoms were assessed using the Beck’s Depression Inventory (BDI)-Fast Screen Questionnaire validated for ages 13 and older and confirmed by the BDI or Hamilton Depression Scale. A cross-sectional analysis of 148 patients attending the rheumatology outpatient clinic of the Asklepios Children’s Hospital Sankt Augustin between January 2018 and May 2019 was performed. Possible associations between routinely assessed parameters of disease activity and treatment were analysed. 148 JIA patients (71.5% female), median age 14.7 years, were included. The prevalence for depressive symptoms was 13% and for depression 9.5%, of which 71.4% were newly identified with depression. Significant associations with depressive symptoms included rheumatoid factor negative polyarthritis, higher pain scores, functional limitations, higher disease activity, decreased general well-being, higher number of medications taken and not being in remission. In addition, poor treatment response (persistent pain despite therapy) and failure to achieve minimal activity/remission of disease despite intensified therapy with biologics correlated significantly with depressive symptoms. Depressive symptoms are an important comorbidity in JIA. Early recognition and treatment of psychological distress is essential to prevent deterioration in quality of life and long-term prognosis. Consequently, treat-to-target principles should include mental health as a therapeutic goal.

show abstract

Psychosocial Evaluation of Adults with Primary Immunodeficiency

Gumusburun,

Altay,

Cengiz

et al. 2024

J Clin Immunol

View full text Add to dashboard Cite

Purpose Primary immunodeficiency disorder (PID) is a heterogeneous group of diseases characterized by immune dysregulation and increased susceptibility to infections, with various cognitive, emotional, behavioral, and social effects on patients. This study aimed to evaluate loneliness, social adaptation, anxiety, and depression and to identify associated factors in adults with immunodeficiency. Methods A cross-sectional study in Turkey (Feb-Aug 2022) obtained sociodemographic data from patient records. The Social Adaptation Self-Evaluation Scale (SASS), UCLA-Loneliness Scale (UCLA-LS), and Hospital Anxiety and Depression Scale (HADS) were administered in individual patient interviews. HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) scores were assessed using cut-offs of 10 and 7, respectively; SASS cut-offs for social imbalance and normalcy were < 25 and > 35, respectively. Results A total of 104 patients (60 women, 44 men) with a median age of 34 years (range: 18–89) were included in the study. Mean scores were SASS: 34.46 ± 8.11, UCLA-LS: 44.89 ± 12.66, HADS-A: 9.87 ± 4.77, and HADS-D: 9.12 ± 4.80. SASS score was negatively correlated with HADS-A, HADS-D, and UCLA-LS scores. There were positive correlations between UCLA-LS and HADS-A (r = -0.355, p < 0.01) and HADS-D (r = -0.614, p < 0.01) and between HADS-A and HADS-D (r = -0.454, p < 0.01). Low-income level was associated with higher HADS-A, HADS-D, and UCLA-LS scores and lower SASS score (p = 0.012, p = 0.041, p = 0.008, and p = 0.001, respectively). Conclusion Adults with PID are at risk for depression and experience high levels of loneliness. Social maladjustment and loneliness contribute to anxiety and depression, and loneliness is correlated with impaired social functioning. These findings emphasize the importance of biopsychosocial evaluation of individuals diagnosed with PID.

show abstract

Psychological burden of pediatric primary immunodeficiency

Abstract: The rate of psychopathology was similar in patients with PID and JIA and higher than the controls. Some of the disease-related factors were associated with the frequency of mood disorders in the PID patients.

Cited by 21 publications

References 24 publications

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Prevalence and risk factors of depressive symptoms in children and adolescents with juvenile idiopathic arthritis

Psychosocial Evaluation of Adults with Primary Immunodeficiency

Contact Info

Product

Resources

About