Psychological comorbidity in diabetes mellitus—need for early recognition and treatment

Abstracts: Anxiety disorder is one of the most prevalent psychiatric disorders. The high prevalence of comorbid gastrointestinal disorders and anxiety, as well as various limitations in current therapy, have necessitated the search for alternative techniques. The Gut-Brain Axis is the connecting link between the gut and the brain. One of the reasons for the Gut-Brain Axis malfunction, that results in HPA axis stimulation and anxiety, is intestinal barrier dysfunction. Gut microorganisms, lipopolysaccharides, and other factors can stimulate the disruption of this intestinal barrier. Tight junction proteins, the epithelial barrier, the mucosal membrane, the Toll-like receptor/Myeloid differentiation factor 88 pathway, the activated immune system, and the HPA axis could all be potential targets for this anxiety caused by intestinal barrier disruption. Quercetin and Rebamipide, Berberine and Agomelatine, Angiotensin II receptor type 1 blockers, and Lubiprostone can act on these targets to provide an anxiolytic effect.

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Psychological comorbidity in diabetes mellitus—need for early recognition and treatment

Cited by 3 publications

References 19 publications

A Comparative Study of Psychopathological Profile Among Chronic Disease Patients: a Report from Health Centers in Malaysia

A Comparative Study of Psychopathological Profile Among Chronic Disease Patients: a Report from Health Centers in Malaysia

Human APRIL and FGF-21 and adhesion molecules in relation to cognitive function in elderly diabetic patients

Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety

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