Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis

Wouters, Mira M.; Wanrooy, Sander Van; Nguyen, Anh B.; Dooley, James; Aguilera‐Lizarraga, Javier; Brabant, W; Garcia-Perez, Josselyn E.; Oudenhove, Lukas Van; Ranst, Marc Van; Verhaegen, Jan; Liston, Adrian; Boeckxstaens, Guy E.

doi:10.1136/gutjnl-2015-309460

Cited by 80 publications

(69 citation statements)

References 39 publications

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“…Wouters and colleagues investigated a cohort of over 18 000 people exposed to contaminated drinking water, finding that pre-existing anxiety and somatisation were linked to a lower immune response and a greater risk of developing GI infection 33. In this respect, psychological disorder may be viewed as a predisposing factor for infection, which in turn is postulated as a cause of IBS.…”

Section: Discussionmentioning

confidence: 99%

Incidence of irritable bowel syndrome and chronic fatigue following GI infection: a population-level study using routinely collected claims data

Donnachie

Schneider

Mehring

et al. 2017

Gut

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Section: Discussionmentioning

confidence: 99%

Incidence of irritable bowel syndrome and chronic fatigue following GI infection: a population-level study using routinely collected claims data

Donnachie

Schneider

Mehring

et al. 2017

Gut

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“…A Turkish case-control study (33) showed that depression among IBS cases was significantly much higher (38%) than among the controls (4%). Another recent study from Belgium reported an increased risk of patients with psychological co-morbidity to develop postinfectious IBS (PI-IBS) (34). Medical students represent a unique stress-heavy lifestyle model, consisting of long hours of focused physical and cognitive activity under significant social-competitive pressure (3,24).…”

Section:  Psychological and Psychiatric Factors (Stress Anxiety Anmentioning

confidence: 99%

A systematic review of the prevalence and risk factors of irritable bowel syndrome among medical students

Ibrahim¹

2016

Turk J Gastroenterol

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“…When Wouters et al [55] explored risk factors for post-infectious IBS (PI-IBS) in a large cohort of subjects exposed to drinking water contaminated with GI pathogens (e.g., norovirus, Giardia lamblia , and Campylobacter jejuni ), the risk of developing symptoms consistent with a FGID was higher in subjects with pre-existing anxiety, as well as in younger individuals. The authors also observed an inverse link between anxiety scores and CD4-positive T-lymphocytes expressing interleukin (IL)-2.…”

Section: Evidence For the Role Of Infections In Fgidmentioning

confidence: 99%

Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

Holtmann

Shah

Morrison

2017

Dig Dis

141

102

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Background and Summary: Traditionally, functional gastrointestinal disorders (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by more or less specific symptoms and the absence of structural or biochemical abnormalities that cause these symptoms. This concept is now considered to be outdated; if appropriate tests are applied, structural or biochemical abnormalities that explain or cause the symptoms may be found in many patients. Another feature of FGID are the highly prevalent psychiatric comorbidities, such as depression and anxiety. It is implied that mood disorders “cause” gastrointestinal symptoms. In fact, epidemiological data now provide strong evidence that in subsets of cases, gastrointestinal (GI) symptoms arise first and mood disorders occur later, while in other patients the reverse appears to happen. Possible mechanisms for gut-brain dysfunction have been identified, with systemic minimal inflammation as a causal factor in at least some subjects. Other mechanisms that play a role in FGID include chronic infections, intestinal microbiota, low-grade mucosal inflammation including the increase of eosinophils, systemic immune activation, altered intestinal permeability, in diarrhea predominant IBS altered bile salt metabolism, abnormalities in the serotonin metabolism and genetic factors. All these factors might be modulated by environmental factors such as diet. Key Messages: While a number of factors can be linked to specific symptoms (e.g., pain or diarrhea), it is evident that the symptom-based categorization of patients will not allow targeted treatments that specifically address the underlying pathophysiology.

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Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis

Abstract: (ClinicalTrials.gov NCT01497847).

Cited by 80 publications

References 39 publications

Incidence of irritable bowel syndrome and chronic fatigue following GI infection: a population-level study using routinely collected claims data

Incidence of irritable bowel syndrome and chronic fatigue following GI infection: a population-level study using routinely collected claims data

A systematic review of the prevalence and risk factors of irritable bowel syndrome among medical students

Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

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