Psychological Differences Between Veterans With and Without Gulf War Unexplained Symptoms

Storzbach, Daniel; Campbell, Keith A.; Binder, Laurence M.; McCauley, Linda; Anger, W. Kent; Rohlman, Diane S.; Kovera, Craig A.

doi:10.1097/00006842-200009000-00017

Cited by 44 publications

(29 citation statements)

References 39 publications

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“…Thus, these data suggest the possibility of sensorimotor deficits in the veterans of PGW, who may have been exposed to PB or sarin. These results are consistent with the epidemiological studies reported by Knoke et al (2000) and Storzbach et al (2000).…”

Section: Discussionsupporting

confidence: 94%

Long-term effects of subchronic exposure to sarin, alone and with stress or other chemicals

Abou‐Donia¹

2002

PsycEXTRA Dataset

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Sewices, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Papenaiork Reduction Project (0704-0188), Washington, DC 20503 Final (25 March 1998 -24 September 2002 AGENCY USE ONLY (Leave blank) REPORT DATE October 2002 REPORT TYPE AND DATES COVERED TITLE AND SUBTITLE Long-Term Effects of Subchronic Exposure to Sarin, Alone and With Stress or Other Chemicals AUTHOR(S)Mohamed B. Abou-Donia, Ph.D. FUNDING NUMBERS DAMD17-98-C-8027 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Duke University Medical Center Durham, North Carolina 27710donia@acpub.duke.edu PERFORMING ORGANIZATION REPORT NUMBER SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012 SPONSORING / MONITORING AGENCY REPORT NUMBER SUPPLEMENTARY NOTESReport contains color. 12a. DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited 12b. DISTRIBUTION CODE ABSTRACT (Maximum 200 Words)The major objective of this proposal is to investigate the consequences of long-term, lowlevel exposure to sarin, alone, and in combination with pyridostigmine bromide (PB) and stress on the development of chronic and neurologic deficits. An important finding from our studies is that brain AChE and plasma BChE inhibition might be used as a biomarker for exposure, not for sarin-induced neurologic deficits. Rats treated with toxic doses of sarin showed inhibition of brain and plasma cholinesterases, that subsequently recovered.On the other hand, these animals exhibited sensorimotor deficit that persisted throughout the six-month observation period. Another significant result from our studies is that a brief insult from a single lethal or sub-lethal dose of sarin, can generate a series of events to result in a diffuse neuronal cell death. Neuronal degeneration was exhibited in the cerebral cortex, the hippocampus, and Purkinje cell neurons in the cerebellum. Stress, caused by immobilization or heat also exacerbated sarin-induced neurotoxicity.The results show that prophylactic treatment with PB offered some protection of peripheral AChE against sarin inhibition.On the other hand, PB exacerbated the toxicity of high doses of sarin.Furthermore, the results showed that treatment with either sarin or PB alone resulted in sensorimotor impairments that persisted throughout the six-month observation period. Neuronal cell death of the motor cortex and Purkinje cells of the cerebellum following exposure to sarin ...

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Section: Discussionsupporting

confidence: 94%

Long-term effects of subchronic exposure to sarin, alone and with stress or other chemicals

Abou‐Donia¹

2002

PsycEXTRA Dataset

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“…The lack of effective inhibition as demonstrated in both behavioral performance and in electrophysiological responses may be able to account for multiple other symptomatic complaints. For example, a lack of effective inhibition can represent a plausible etiology for the deficits in executive function [3,8,14,15,58,59], attention [8,[59][60][61][62], and abstraction/problem solving [60,63]. Because it can account for such a wide array of symptoms, impairment in inhibition is compatible with the variety of complaints reported by GW veterans, although they may not specifically report 'a lack of inhibition.'…”

Section: Discussionmentioning

confidence: 99%

Impaired response inhibition in ill Gulf War veterans

Tillman

Green

Ferrée

et al. 2010

Journal of the Neurological Sciences

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“…The test battery consisted of eight tests of the ATSDR Adult Environmental Neurobehavioral Test Battery (ATSDR, 1995) and six tests of the Oregon Health and Sciences University's Behavioral Assessment and Research System (BARS). A 36-item questionnaire was used to assess possible psychological or medical problems (Storzbach et al, 2000). The Spanish version protocol was pilot tested at the Oregon Health and Sciences University's CROET laboratory (Portland, OR).…”

Section: Neurobehavioral Testsmentioning

confidence: 99%

Neurobehavioral evaluation for a community with chronic exposure to hydrogen sulfide gas

Inserra

Phifer

Anger

et al. 2004

Environmental Research

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In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H 2 S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in an area with repeated exposure to H 2 S showed poorer performance on neurobehavioral tests than unexposed residents. Study participants were required to meet age (X16 years of age) and length of residency (2 years) eligibility requirements. A battery of computer-assisted standardized neurobehavioral tests was administered in English or Spanish. A questionnaire was used to collect information about participants, demographic and health status. Three hundred forty-five people agreed to participate. After the exclusion of 10 persons, analyses were conducted on 335 participants; 171 residents in the target area and 164 residents in the comparison area. The two groups were comparable in demographic characteristics and various health conditions. Overall, neurobehavioral test results for the target and comparison groups were similar. Residence in the H 2 S-exposed area was associated with marginally poorer performance on a test of memory, namely, match to sample score, and a test of grip strength. However, these differences were not significant. Deficits in overall neurobehavioral performance were not associated with exposure to H 2 S in this study. r

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Psychological Differences Between Veterans With and Without Gulf War Unexplained Symptoms

Cited by 44 publications

References 39 publications

Long-term effects of subchronic exposure to sarin, alone and with stress or other chemicals

Long-term effects of subchronic exposure to sarin, alone and with stress or other chemicals

Impaired response inhibition in ill Gulf War veterans

Neurobehavioral evaluation for a community with chronic exposure to hydrogen sulfide gas

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