Psychological disorders, adverse childhood experiences and parental psychiatric disorders in children affected by headache: A systematic review

Polese, Daniela; Belli, Arianna; Esposito, Dario; Evangelisti, Melania; Luchetti, Anna; Nardo, Giovanni Di; Parisi, Pasquale; Bruni, Oliviero

doi:10.1016/j.neubiorev.2022.104798

Cited by 18 publications

(19 citation statements)

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“…Furthermore, heterogeneity was not explained by study characteristics, including assessment of ACEs with different screening tools, methods of ascertaining primary headaches, types of primary headaches, study design, and publication year, supporting the internal validity of our findings. Beyond the scope of this study, we are aware that among individuals who have ACEs, it is possible to develop primary headache disorders in childhood and adolescence [35][36][37][38] and hope that future researchers can explore this important relationship prospectively and longitudinally. The relationship between ACEs and headache disorders and other common comorbidities (e.g., anxiety and depression) should also be further explored prospectively in large population studies.…”

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Primary Headache Disorders

Sikorski,

Mavromanoli,

Manji

et al. 2023

Neurology

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Background and Objectives:Headache disorders are among the leading causes of disability worldwide. While an association between adverse childhood experiences and primary headaches has been reported, the pooled magnitude across studies and pathways of the association are unknown. Our objectives were 1) to estimate the pooled effect of ≥1 adverse childhood experience (ACE) on primary headache disorders in adulthood, and 2) test the hypothesis that ACEs categorized as “threat” or “deprivation” have distinct impacts on primary headaches based on a selected theory from our narrative review of how ACEs impact development along the life course.Methods:PubMed, EMBASE, Medline, Web of Science, Google Scholar, Biological Psychiatry, and grey literature were searched up to Mar 16, 2023 (PROSPERO, CRD42020223403). Selected articles included: 1) observational studies with a comparator group, 2) ACEs that occurred before age 18, and 3) primary headaches, occurring ≥21 years of age. Pooled odds ratios (ORs) were calculated using a multilevel linear random-effects model. The narrative review included theories that describe how ACEs impact human development and disease across the life course. We selected a theory from our narrative review and tested ACEs categorized according to this theory for any modification of point estimates.Results:Our search identified 32 studies, of which 28 were eligible for meta-analysis (n = 154,739 participants, 19 countries). The occurrence of ≥1 adverse childhood experience(s) was associated with primary headaches [pooled OR = 1.48 (95% CI 1.36-1.61); high-quality evidence, 134,696 participants]. As the number of ACEs increased, the odds of primary headaches increased [Range: 1 ACE OR = 1.24 (95% CI 1.14-1.35) to ≥4 ACEs OR= 2.09 (1.83-2.38), p-value for trend <0.0001]. From the narrative review, a neurodevelopmental theory that categorizes ACEs into threat or deprivation was tested and both were independently associated with primary headaches [threat OR=1.46 (95% CI: 1.32-1.60) and deprivation OR=1.35 (95% CI: 1.23-1.49), respectively], accounting for heterogeneity (p = 0.021).Discussion:This systematic review and meta-analysis confirm that ACEs are important risk factors for primary headache disorders in adulthood. Our findings provide epidemiological support that ACEs categorized as threat and deprivation may manifest as distinct pathways of early adversity.

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Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experiences and Primary Headache Disorders

Sikorski,

Mavromanoli,

Manji

et al. 2023

Neurology

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“…ACEs such as psychological and/or physical abuse, loss, neglect, parents’ separation/divorce and family psychiatry history have been also reported in two out of three suicide attempts in adult life [ 44 ]. The mental health disorders associated with ACE start to be reported in adolescence until adulthood [ 45 ]. Additionally, somatoform complaints such as headache presented a higher prevalence in ACE cases.…”

Section: Psychopathology Features and Developmental Pathwaysmentioning

confidence: 99%

“…The headache prevalence has an estimated 2-fold higher increase in those cases presenting with more than two traumatic events during childhood. Additionally, the presence of chronic somatoform pain complaints (i.e., general pain; back pain) has been associated with more than one adverse childhood experience, with an increased prevalence of 1.2–1.3-fold [ 41 , 45 ].…”

Section: Psychopathology Features and Developmental Pathwaysmentioning

confidence: 99%

“…Psychosocial stressors related to social and economic status, family conditions and academic performance, as well as psychiatric and somatic comorbidities and behavioral problems, can contribute to or worsen TTH. When these dynamics are detected, a biopsychosocial approach to care should be adopted [ 45 , 83 ]. Such an approach may also be useful considering that children with TTH in some cases live with negative parental relationships or in disadvantaged family environments from emotional, economic, or socio-cultural points of view [ 83 , 84 ].…”

Section: Treatment Strategiesmentioning

confidence: 99%

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Tension-Type Headache in Children and Adolescents

Baglioni

Orecchio

Esposito

et al. 2023

Life

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In pediatric neurology, tension-type headache (TTH) represents a very common type of primary headache during the pediatric age. Despite the high prevalence of TTH, this diagnosis is often underestimated in childhood, with relevant difficulties in the differential diagnosis of TTH from secondary and primary headache manifestations. Even among primary headaches, a clinical overlap is not so infrequent in children: migraine attacks could present tension headache-like features while tension-type headaches may display migraine-like symptoms as well. Several variables play a role in the complex trajectory of headache evolution, such as hormonal changes during adolescence, triggers and genetic and epigenetic factors. The trajectories and outcomes of juvenile migraine and TTH, as well as the transition of one form to the other, have been investigated in several long-term prospective studies. Thus, the aim of this paper is to review the current literature on the differential diagnosis workout of TTH in pediatrics, the possible outcomes during the developmental age and the appropriate therapeutic strategies. Indeed, TTH represents a challenging diagnostic entity in pediatrics, both from a clinical and a therapeutic point of view, in which early diagnosis and appropriate treatment are recommended.

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“…It has been reported that adverse events in environmental, family and social context affect the development or exacerbation of pathological conditions, especially in childhood, making individuals more vulnerable during adolescence and young adulthood [12,13].…”

Section: Introductionmentioning

confidence: 99%

The impact of Covid-19 on menstrual cycle’s alterations, in relation to depression and sleep disturbances: a prospective observational study in a population of medical students

Polese

Costanzi

Bianchi

et al. 2023

Preprint

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Background: The sars-Cov-2 pandemic has determined adverse circumstances beyond everyday experience, leading to psychological stress, with particular relevance to the young population of female medical students. This work aims at studying the impact of the pandemic on menstrual cycle alteration in relation to psychological stress, monitoring the presence of depression, sleep disturbances and post-traumatic stress, on a population of medical students. Methods: 293 female students (23,08 years old ±3,8) were enrolled. One year after quarantine, a personal data sheet on menstrual cycle, the Beck Depression Inventory (BDI) and the Impact of Event Scale (IES-R) have been administered. Results: A statistically significant association between menstrual alterations and stress during pandemic has been found. The onset of depressive symptoms and sleep disturbances has been observed in 57,1% and in 58,1% of young women with cycle’s alterations, respectively. Amenorrhea was three times more common in female students with depressive symptoms, PMS had a significant correlation with both depression and sleep disturbances. Pandemic has been related to menstrual alterations, with depressive symptoms and sleep disorders. Amenorrhea is connected to depression, as observed on the functional hypothalamic amenorrhea (FHA). Conclusions: Post-traumatic stress disorder has not been found, it may be more likely associated with high physical and psychological stress in frontline female health workers during the pandemic. New strategies of psychological intervention should be considered after pandemic experience, in order to help students, and particularly medical trainees, with specific attention to women’s needs.

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Psychological disorders, adverse childhood experiences and parental psychiatric disorders in children affected by headache: A systematic review

Cited by 18 publications

References 103 publications

Adverse Childhood Experiences and Primary Headache Disorders

Adverse Childhood Experiences and Primary Headache Disorders

Tension-Type Headache in Children and Adolescents

The impact of Covid-19 on menstrual cycle’s alterations, in relation to depression and sleep disturbances: a prospective observational study in a population of medical students

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