Psychological Distress and All-Cause, Cardiovascular Disease, Cancer Mortality Among Adults with and without Diabetes

Huang, Wentao; Aune, Dagfinn; Ferrari, Gérson; Zhang, Lei; Lan, Yutao; Nie, Jing; Chen, Xiong; Xu, Di; Wang, Yafeng; Rezende, Leandro F. M.

doi:10.2147/clep.s308220

Cited by 12 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In IPD-Work, work-related stress was not associated with total mortality among healthy employees, but a 1.6-fold increased risk of death was observed among stressed men with cardiometabolic disease (diabetes, myocardial infarction or stroke), with the contribution of stress being clinically significant and independent of conventional risk factors and their treatment 156 . A similar interaction was observed in another large-scale study of over 485,000 adults who participated in the National Health Interview Survey 157 . During 8-year follow-up, severe psychological distress was associated with a 2-fold increased risk of death in individuals with diabetes but only 1.5-fold increased risk in non-diabetic people, while the corresponding relative risks were 2.0-and 1.4fold for cardiovascular deaths.…”

Section: Stress and Disease Progressionsupporting

confidence: 80%

The multiple roles of life stress in metabolic disorders

2022

View full text Add to dashboard Cite

The stress response is evolutionarily conserved across vertebrates to maintain homeostasis, but in excess can be damaging for body functions. We review the most recent research from basic sciences and epidemiology linking stress to the development and progression of metabolic disorders across the life course. Findings from rodents demonstrate that stress can affect features of metabolic dysfunction, such as insulin resistance, glucose and lipid homeostasis, as well as fundamental ageing processes such as cellular senescence and telomere length shortening. In human studies, stressors in the home, workplace and neighbourhood are associated with accelerated biological ageing and metabolic and immune alterations, both directly as well as indirectly via behavioural risks, including low physical activity, sleep disturbances, and alcohol abuse. The likelihood of developing clinical conditions, such as diabetes and fatty liver disease is increased in individuals with adverse childhood experiences or long-term stress at work or in private life -often as part of disease trajectories associated with other stress-related disorders, such as mental health problems, cardiovascular disease and increased susceptibility to infections. Among people with a metabolic disorder, stress may worsen disease prognosis. As favourable modifications in stressors are associated with reductions in incidence of metabolic disorders, the therapeutic value of targeting stress in personalised medicine merits further investigation.

show abstract

Section: Stress and Disease Progressionsupporting

confidence: 80%

The multiple roles of life stress in metabolic disorders

2022

View full text Add to dashboard Cite

show abstract

“…Similar to the results previously published by Zaorsky et al [ 17 ], we found that the risk of CVM in BC patients was highest in the first 10 months after diagnosis. Meanwhile, the study by Fang and Ye et al suggested that newly diagnosed cancer may lead to psychological and emotional distress in cancer patients, which in part promotes the development of CVM [ 18 , 19 ]. Therefore, psychiatric assessment and psychological support are necessary for newly diagnosed BC patients.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Mortality Risk in Patients with Bladder Cancer: A Population-Based Study

Shun-de

Zhang

2022

JCDD

View full text Add to dashboard Cite

Background: The purpose of this study was to evaluate the risk of cardiovascular mortality (CVM) among patients with bladder cancer (BC). Methods and Materials: Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database for patients who were diagnosed with BC by pathology between 2000 and 2016. The standardized mortality rate (SMR) was calculated based on reference data from the general population. Nelson–Aalen cumulative hazard curves were used to assess the risk of experiencing CVM in BC patients. Multivariate competing risk models were performed. Results: In total, data from 237,563 BC patients were obtained from the SEER database for further analysis, of which 21,822 patients experienced CVM; the overall SMR for CVM in BC patients was 1.16 (95% CI: 1.14–1.17). Age, race, sex, year of diagnosis, histologic type, summary stage, surgery, marital status, and college education level were independent predictors of CVM in patients with BC. Conclusions: Patients with BC have a significantly increased risk of experiencing CVM compared to the general population. Pre-identification of high-risk groups and cardiovascular protection interventions are important measures to effectively improve survival in this group of patients.

show abstract

“…To create a comorbidities score, we used data the participants’ self-reported medical diagnosis of asthma, diabetes, hypertension, liver conditions, and/or weak or failing kidney function. In addition, we considered self-rated health (rated as excellent, very good, good, fair, or poor), mobility difficulties (not at all difficult/only a little; somewhat difficult to walk one-quarter of a mile [approximately 3 city blocks]; somewhat difficult to ascend 10 steps without resting), and psychological distress based on the Kessler 6 scale …”

Section: Methodsmentioning

confidence: 99%

“…In addition, we considered self-rated health (rated as excellent, very good, good, fair, or poor), mobility difficulties (not at all difficult/only a little; somewhat difficult to walk onequarter of a mile [approximately 3 city blocks]; somewhat difficult to ascend 10 steps without resting), and psychological distress based on the Kessler 6 scale. 16,17…”

Section: Covariatesmentioning

confidence: 99%