Burnout has been identified as a significant factor in HIV=AIDS volunteering. It has been associated with depression, anxiety, and the loss of volunteers from the health care delivery system. The aim of this study was to test the independence of the health and motivational processes hypothesized within the Job DemandsResources model of burnout in HIV=AIDS volunteers. Participants were 307 HIV=AIDS volunteers from state AIDS Councils throughout Australia who completed self-report measures pertaining to role ambiguity and role conflict, social support, burnout, intrinsic and organizational satisfaction, and depression. Findings suggested that the independence of the dual processes hypothesized by the model was only partially supported. These findings provide a model for burnout that gives a framework for interventions at both the individual and organizational levels, which would contribute to the prevention of burnout, depression, and job dissatisfaction in HIV=AIDS volunteers.