Purpose: In England, healthcare policy promotes specialised ageappropriate cancer services for teenagers and young adults (TYA), for those aged 13-24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced age-specific care for TYA, although many still receive all or some of their care in adult or children's cancer services. Our aim was to determine the patient-reported outcomes associated with TYA-PTC based care.Methods: We conducted a multi-centre cohort study, recruiting 1,114 TYA aged 13-24 years at diagnosis. Data collection involved a bespoke survey at 6,12,18,24 and 36-months after diagnosis. Confounder adjusted analyses of perceived social support, illness perception, anxiety and depression, and health status, compared patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care.Results: Eight hundred and thirty completed the first survey. There was no difference in perceived social support, anxiety or depression between the three categories of care. Significantly higher illness perception was observed in the ALL-TYA-PTC and SOME-TYA-PTC group compared to the