Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review

Wu, Hong; Li, Chenxing; Zheng, Tao; Feng, Kaiyue; Wu, Yue

doi:10.1016/j.ijcard.2022.05.048

Cited by 16 publications

(11 citation statements)

References 65 publications

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“…Similar results were reported in a previous large meta-analysis that found that negative psychological characteristics such as anxiety, anger, depression, and work stress were associated with an increased risk of atrial brillation (AF), with anxiety and depression linked to 10% and 25% increases in the incidence of AF, respectively. Signi cant job stress was also linked to an 18% increase in the risk of AF [24].…”

Section: Discussionmentioning

confidence: 99%

Perceived Social Support: Correlation with Depression and Symptom Severity in Atrial Fibrillation Patients

Elsheikh,

Sadek,

Abdel-Hassib

et al. 2023

Preprint

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Background Atrial fibrillation can significantly impair daily functioning and impact the patient's quality of life, both physically and psychologically. Approximately one-third of patients with atrial fibrillation experience anxiety and depression. This study aimed to examine the relationship between perceived social support and the severity of atrial fibrillation (AF) symptoms among depressed and nondepressed AF patients. Methods This cross-sectional study was conducted at Al-Azhar University Hospitals, assessing depression using the Patient Health Questionnaire depression scale (PHQ-9) and Multidimensional Scale of Perceived Social Support (MSPSS) to assess social support. AF was graded according to the modified European Heart Rhythm Association (mEHRA). Results Our study involved a total of 93 atrial fibrillation patients; 32 were nondepressed compared to 61 with depression; 41.9% of the participants were female, with a mean age of 63.2 ± 10.89. Most participants (59.2%)were classified as having grade II AF. Only 17.2% of the participants reported low levels of social support. Among depressed patients, 15.1% reported severe depression. Linear regression analysis found that social support was negatively correlated with depression scores (β = -0.735). Multivariate logistic regression revealed that social support was negatively associated with depression (OR = 0.465, P = 0.001). Ordinal regression showed that low social support was the most significant variable affecting AF grades (OR = 35.939, P = 0.024). Conclusion Our findings highlight the need for social support for patients with AF; higher social support was negatively associated with depression, and lower social support was significantly associated with higher AF grades. This implies that healthcare practitioners should prioritize the psychological aspects to improve the health outcomes of patients with AF.

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Section: Discussionmentioning

confidence: 99%

Perceived Social Support: Correlation with Depression and Symptom Severity in Atrial Fibrillation Patients

Elsheikh,

Sadek,

Abdel-Hassib

et al. 2023

Preprint

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“… 26 , 27 , 28 , 29 In the recent meta-analyses, the risk of AF was increased by anxiety, anger, depression, antidepressant use, and work stress. 30 , 31 These studies focused on the psychological traits that seem to be the result of neuroticism coping with the outer stimulus and not neuroticism itself. Previous studies have focused chiefly on the effect of AF on patients’ quality of life via neuroticism and not vice versa.…”

Section: Discussionmentioning

confidence: 99%

Neuroticism and the Risk of Atrial Fibrillation

Rhee,

Choi,

Choi

et al. 2024

JACC: Asia

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“…A meta-analysis demonstrated that the incidence of AF was increased by 15% for patients with anger ( 9 ). A Swedish cohort study also found that anger increased the risk of AF ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some prospective studies suggested that the level of anger had a dose–response relationship with CAD ( 7 , 8 ). Meanwhile, irritability also increased the risk of AF ( 9 ), HF ( 10 ), hypertension ( 11 ), and stroke ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

A causal relationship between irritability and cardiovascular diseases: a Mendelian randomization study

Cai

Yin

Song

et al. 2023

Front. Cardiovasc. Med.

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BackgroundObservational studies have suggested that irritability is associated with a higher risk of cardiovascular disease (CVD). However, the potential causal association is not clear. Therefore, we used Mendelian randomization (MR) analysis to assess the causal association of irritability with CVD risk.MethodsA two-sample MR analysis was performed to confirm the causal association of irritability with the risk of several common CVDs. The exposure data were derived from the UK biobank involving 90,282 cases and 232,386 controls, and outcome data were collected from the published genome-wide association studies (GWAS) and FinnGen database. Inverse-variance weighted (IVW), MR-Egger, and weighted median methods were performed to assess the causal association. Furthermore, the mediating effect of smoking, insomnia, and depressed affect was explored by using a two-step MR.ResultsThe MR analysis indicated that genetically predicted irritability increased the risk of CVD, including coronary artery disease (CAD) (Odds ratio, OR: 2.989; 95% confidence interval, CI: 1.521–5.874, p = 0.001), myocardial infarction (MI) (OR: 2.329, 95% CI: 1.145–4.737, p = 0.020), coronary angioplasty (OR: 5.989, 95% CI: 1.696–21.153, p = 0.005), atrial fibrillation (AF) (OR: 4.646, 95% CI: 1.268–17.026, p = 0.02), hypertensive heart disease (HHD) (OR: 8.203; 95% CI: 1.614–41.698, p = 0.011), non-ischemic cardiomyopathy (NIC) (OR: 5.186; 95% CI: 1.994–13.487, p = 0.001), heart failure (HF) (OR: 2.253; 95% CI: 1.327–3.828, p = 0.003), stroke (OR: 2.334; 95% CI: 1.270–4.292, p = 0.006), ischemic stroke (IS) (OR: 2.249; 95% CI: 1.156–4.374, p = 0.017), and ischemic stroke of large-artery atherosclerosis ISla (OR: 14.326; 95% CI: 2.750–74.540, p = 0.002). The analysis also indicated that smoking, insomnia, and depressed affect play an important role in the process of irritability leading to cardiovascular disease.ConclusionOur findings support the first genetic evidence of the causality of genetically predicted irritability with the risk of developing into CVDs. Our results deliver a viewpoint that more early active interventions to manage an individual's anger and related unhealthy lifestyle habits are needed to prevent the occurrence of adverse cardiovascular events.

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Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review

Cited by 16 publications

References 65 publications

Perceived Social Support: Correlation with Depression and Symptom Severity in Atrial Fibrillation Patients

Perceived Social Support: Correlation with Depression and Symptom Severity in Atrial Fibrillation Patients

Neuroticism and the Risk of Atrial Fibrillation

A causal relationship between irritability and cardiovascular diseases: a Mendelian randomization study

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