Psychological factors associated with hand dermatoses: which subgroup needs additional psychological care?

Niemeier, V.; Nippesen, M.; Kupfer, Jörg; Wb, Schill; Gieler, Uwe

doi:10.1046/j.1365-2133.2002.04716.x

Cited by 87 publications

(85 citation statements)

References 22 publications

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“…For example, a close relationship between itch and psychological factors has been demonstrated in hand dermatoses, especially in patients who were convinced that stress was a major trigger of their disease (76).…”

Section: Psychoemotional Stress Triggers or Enhances Itchmentioning

confidence: 99%

Frontiers in pruritus research: scratching the brain for more effective itch therapy

Paus

Schmelz

Bı́ró

et al. 2006

Journal of Clinical Investigation

331

287

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This Review highlights selected frontiers in pruritus research and focuses on recently attained insights into the neurophysiological, neuroimmunological, and neuroendocrine mechanisms underlying skin-derived itch (pruritogenic pruritus), which may affect future antipruritic strategies. Special attention is paid to newly identified itch-specific neuronal pathways in the spinothalamic tract that are distinct from pain pathways and to CNS regions that process peripheral pruritogenic stimuli. In addition, the relation between itch and pain is discussed, with emphasis on how the intimate contacts between these closely related yet distinct sensory phenomena may be exploited therapeutically. Furthermore, newly identified or unduly neglected intracutaneous itch mediators (e.g., endovanilloids, proteases, cannabinoids, opioids, neurotrophins, and cytokines) and relevant receptors (e.g., vanilloid receptor channels and proteinase-activated, cannabinoid, opioid, cytokine, and new histamine receptors) are discussed. In summarizing promising new avenues for managing itch more effectively, we advocate therapeutic approaches that strive for the combination of peripherally active antiinflammatory agents with drugs that counteract chronic central itch sensitization. The study of pruritus in a nutshellItching (pruritus) is perhaps the most common symptom associated with numerous skin diseases and can be a lead symptom of extracutaneous disease (e.g., malignancy, infection, and metabolic disorders) (1, S1). However, despite approximately a century of pruritus research (2, S2, S3), there is no generally accepted therapy for the treatment of itch, and many mysteries, misconceptions, and controversies still haunt this rather neglected, yet clinically important and scientifically fascinating, niche in the life sciences (3, 4, 5). It is the brain that itches, not the skinPruritus causes the desire to scratch the skin and is experienced as a sensation arising in the skin. However, like all other skin sensations, itch, strictly speaking, is an extracutaneous event - a product of CNS activities. The intense itch we feel after an insect bite, in a patch of atopic eczema, during an episode of food-induced urticaria, or in association with diabetes, uremia, or scabies mite infection (S1) represents a neuronal projection of a centrally formed sensation into defined regions of the integument (localized pruritus) or into large territories of our body surface (generalized pruritus).Interestingly, our individual reception of and emotional response to itch strongly depends on its exact quality: while a tickling sensation usually is experienced as pleasurable, persistent itch is an annoying or even torturous sensation (S4). While one is tempted to interpret this as indicating a distinct molecular and/or structural basis of these different itch qualities, it has proven excruciatingly difficult to identify their molecular, structural, and neurophysiological differences (ref. 1; see below).As pruritus can arise from localized or systemic, peripheral o...

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Section: Psychoemotional Stress Triggers or Enhances Itchmentioning

confidence: 99%

Frontiers in pruritus research: scratching the brain for more effective itch therapy

Paus

Schmelz

Bı́ró

et al. 2006

Journal of Clinical Investigation

331

287

View full text Add to dashboard Cite

show abstract

“…A cumulative score is determined by adding the scores of the individual items. The responders were grouped on the basis of their Beck Depression Inventory total scores by means of the following classification: (1) no or minimal depression (score, 0-13), (2) mild depression (score, [14][15][16][17][18][19], (3) moderate depression (score, [20][21][22][23][24][25][26][27][28], and (4) severe depression (score, .…”

Section: Depression and Health-related Qolmentioning

confidence: 99%

“…10,[15][16][17] It has been suggested that patients with contact dermatitis may experiencedepressivesymptoms. [18][19][20] Sofar,nodata are available on the possible associations between depression and the prognosis of patients with OHE. Poor socioeconomic status has been shown to affect outcome adversely in many chronic disorders, but no current data are available for patients with OHE.…”

mentioning

confidence: 99%

Prognosis of Occupational Hand Eczema

Cvetkovski

Zachariae

Jensen³

et al. 2006

Arch Dermatol

123

117

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“…De los estudios comunitarios realizados en Noruega 4,6 y otros países [7][8][9] , sabemos que los individuos con picazón en la piel, eccema y psoriasis tienen el doble de probabilidades de estar deprimidos que la población en general 10 . Se ha demostrado que la depresión comórbida, la ansiedad y la ideación suicida son comunes en pacientes con afecciones cutáneas 11 .…”

Section: Impacto Psicológico Del Cáncer De Piel En La Vejezunclassified

Repercusión emocional del cáncer de piel y el envejecimiento cutáneo

Valladolid¹

2017

Más Dermatol

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Psychological factors associated with hand dermatoses: which subgroup needs additional psychological care?

Abstract: Psychological factors should be taken into consideration in the treatment of patients with HD. High-SR patients with a negative patch-test seem to require more adjuvant psychological care.

Cited by 87 publications

References 22 publications

Frontiers in pruritus research: scratching the brain for more effective itch therapy

Frontiers in pruritus research: scratching the brain for more effective itch therapy

Prognosis of Occupational Hand Eczema

Repercusión emocional del cáncer de piel y el envejecimiento cutáneo

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