“…In humans, prospective studies have not shown any direct relationship between stressful life events and frequency of recurrence of HSV 23,24 , although those who suffer frequent recurrences believe the two to be linked 25 , and score more highly on stress indices than those with less frequent recurrences 26 . There is, however, support for a link between negative mood (de® ned as anxiety, depression and hostility) and frequency of recurrence 24,27 . Two studies have detected increased levels of anxiety in the 4 to 10 days preceding a recurrence 28,29 , independent of prodromal symptoms 29 .…”