Psychological Factors Influence the Overlap Syndrome in Functional Gastrointestinal Disorder and Quality of Life among Psychiatric Patients in South Korea

Abstract

Objective The aim of this study was to investigate the predictor variables that could influence overlap syndrome in functional gastrointestinal disorders (FGID) among psychiatric patients.Methods Data collected from 170 outpatients visiting the psychiatric clinic at a university hospital. FGIDs were screened according to the Rome III questionnaire-Korean version. Demographic factors were investigated, and psychosocial factors were evaluated using the Hospital Anxiety Depression Scale, Patient Health Questionnaire-15, Childhood Trauma Questionnaire-Korean and the Short form health survey. Chi-squared test, Student’s t-test, one-way ANOVA, and Pearson’s correlation test were used as statistical analysis methods.Results There were no differences in the epidemiologic data between the two groups divided according to the FGID status. In those with FGID overlap syndrome, FD-NERD was most common (n=29), followed by IBS-NERD (n=20). Patients with overlap syndrome had the highest depressive, anxiety, and somatic symptoms. The overlap syndrome group had the lowest physical component summary and mental component summary. FGID symptom severity was significantly correlated with PCS and MCS in the overlap syndrome group.Conclusion Psychological factors are associated with the overlap syndrome of FGID. Acknowledging this common comorbidity may facilitate the recognition and treatment of patients with FGID.

Sex and Gender Differences in Overlap Syndrome of Functional Gastrointestinal Disorder and Effect of Genetic Polymorphisms in South Korea: A Long-term Follow-up Study

“…However, there was no significant association between age, gender in patients with overlap syndrome. 40 Lee et al 11 found that, in psychiatric patients, the NERD-FD overlap was the most common among NERD, FD, IBS, and functional constipation.…”

“…Patients with overlap syndrome also reported more frequent and severe GI symptoms, more severe depressive symptoms, and lower quality of life (QoL) than those with single FGID. 11 In actual clinical practice, overlap FGID can be frequently encountered, and it is important to know the clinical course of overlap FGID because these patients have severe symptoms and are highly likely to be related to psychosocial factors without responding to conservative treatment. However, there have been only few studies on the overlap syndrome 12 - 15 and on follow-up 16 , 17 ; therefore, studies on the characteristics of patients with overlap syndrome and their associated risk factors are insufficient.…”

A Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study

“…Moreover, 100.00% (30/30) and 96.67% (29/30) of subjects in the DA-9701 group and placebo group, respectively, also had FD, which was consistent with previous studies showing that many patients with IBS are accompanied by FD. [27][28][29] As a result of efficacy evaluation, there was no statistically significant difference in the proportion of responders with appropriate improvement in overall symptoms of IBS-C. However, the proportion of responders was higher with 53.33% (16/30) in the DA-9701 group than in the placebo group with 40.00% (12/30).…”

Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities

“…Further, individuals meeting criteria for multiple FGIDs have been shown to suffer both greater gastrointestinal symptom burden 7 and greater psychological symptom burden. [7][8][9] The theoretical conception of gastrointestinal disorders is that symptom clusters defining one gastrointestinal disorder are distinct from another, even among FGIDs. Hence, FD is a distinct syndrome from gastroesophageal reflux disorder (GERD).…”