Purpose: to study gender-related peculiarities of psychological mechanisms of behavioral risk of HIV infection. Methods. The psychotype of the test subjects from the experimental group (17 men and 17 women-HIV-infected patients of the Volgograd AIDS Center), and the comparison groups (38 men and 22 women, graduate students and University professors of Volgograd, characterized by the lack of behavioral risk of HIV infection) was evaluated by a set of indicators of social activity and social destructiveness, adventurism, risk appetite, extroversion and neuroticism, accentuation of temperament and character. 112 men and 112 women, part-time students of Volgograd universities, selected by a simple random sample, who studied the relationship of the identified psychological indicators of the risk of HIV infection and personal characteristics of a person, taking into account gender, were involved as a control group of observation. Results. HIV-infected subjects, relative to persons with no behavioral risk of HIV infection, are characterized by the predominance of social destructiveness, reaching statistically significant differences for women (p = 0.014) and having a tendency to the significance of differences (p = 0.053) in men, as well as the prevalence of adventurism, reaching statistically significant differences for both men (p = 0.022) and women (p = 0.003). In the control group of observation, in men with respect to social destructiveness, a direct relationship with extroversion (p = 0,002), neuroticism (p = 0,049), pedantry (p = 0,008), excitability (p = 0,024) and emotivity (p = 0,047) was revealed. In the group of women presented indicators are characterized by negative relationship with social destructiveness by extroversion (p = 0,037), neuroticism (p = 0,049), excitability (p = 0,043) and emotivity (p = 0,031). Conclusions. The role of the inversion of gender psychotype on extroversion, neuroticism, accentuation of temperament and character in shaping the propensity of men and women to risky behavior is grounded.