Psychological Impact of Prophylactic Oophorectomy in Women at Increased Risk of Developing Ovarian Cancer: A Prospective Study

Tiller, Kerry; Meiser, Bettina; Butow, Phyllis; Ma, Chi; Thewes, Belinda; Friedlander, Michael; Tucker, Katherine

doi:10.1006/gyno.2002.6737

Cited by 72 publications

(52 citation statements)

References 27 publications

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“…Likewise, the anxiety level appeared to be reasonably low. This is in line with previous reports in such populations of women who opted for prophylactic surgery [5,[13][14][15]. However, this population appeared to have high endocrine symptom scores and lower sexual functioning.…”

Section: Discussionsupporting

confidence: 92%

Factors Associated with Altered Long-Term Well-Being After Prophylactic Salpingo-Oophorectomy Among Women at Increased Hereditary Risk for Breast and Ovarian Cancer

et al. 2011

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After completing this course, the reader will be able to:1. Describe factors associated with decreased well-being after PBSO in order to prospectively identify patients at risk.2. Provide pre-operative counseling and information to patients at risk of decreased well-being after PBSO.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTBackground. Prophylactic bilateral salpingo-oophorectomy (PBSO) might alter several components of wellbeing, such as sexual functioning and endocrine symptoms, in women at high risk for hereditary breast and/or ovarian cancer, compared with the general pop-

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Section: Discussionsupporting

confidence: 92%

Factors Associated with Altered Long-Term Well-Being After Prophylactic Salpingo-Oophorectomy Among Women at Increased Hereditary Risk for Breast and Ovarian Cancer

et al. 2011

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“…Interest in bilateral prophylactic oophorectomy was limited, and there was no apparent interest in prophylactic hysterectomy. In contrast, uptake of bilateral prophylactic oophorectomy and mastectomy among women carrying a BRCA1/BRCA2 mutation is high, 39,40 reflecting the low efficacy of screening, the proven efficacy of prophylactic surgery, 41,42 and the high lifetime risk of ovarian carcinoma among BRCA1 mutation carriers.…”

Section: Discussionmentioning

confidence: 99%

Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma

Collins

Meiser

Gaff

et al. 2005

Cancer

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BACKGROUNDPrevention benefits from predictive genetic testing for cancer will only be fully realized if appropriate screening is adopted after testing. The current study assessed screening and preventive behaviors during 12 months after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma (HNPCC) in an Australian clinical cohort.METHODSParticipants received predictive genetic testing for HNPCC at one of five Australian familial cancer clinics. Data on self‐reported screening behaviors (colonoscopy, and endometrial sampling and transvaginal ultrasound for women) and prophylactic surgery (colectomy, and hysterectomy and bilateral oophorectomy for women) were collected using postal questionnaires before (baseline) and 12 months after receipt of genetic test results. Age, gender, perceived risk of cancer, and cancer‐specific distress were assessed as predictors of colonoscopic screening.RESULTSIn the current study, 114 participants returned baseline questionnaires (32 carriers and 82 noncarriers of an HNPCC mutation). Ninety‐eight participants also returned a 12‐month follow‐up questionnaire. Of those ≥ 25 years, 73% reported having had a colonoscopy before genetic testing. At follow‐up, 71% (15 of 25) of carriers and 12% (8 of 65) of noncarriers reported having a colonoscopy in the 12 months after receipt of test results. The reduction in colonoscopy among noncarriers was statistically significant (P < 0.001). High perceived risk was associated with colonoscopy at baseline. At follow‐up, mutation status was the only variable significantly associated with colonoscopy. Among female mutation carriers, 47% reported having transvaginal ultrasonography and 53% endometrial sampling during follow‐up. There was low uptake of prophylactic surgery for colorectal, endometrial, or ovarian carcinomas.CONCLUSIONSThe majority of individuals reported appropriate screening behaviors after predictive genetic testing for HNPCC. The small group of noncarriers who had screening after genetic testing might benefit from additional counseling. Cancer 2005. © 2005 American Cancer Society.

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“…Women's attitude about BPSO is a significant and useful indicator of actual uptake, as is age. No significant association between cancer worry and uptake was found, although anxiety was significantly reduced after BPSO and women expressed a high level of satisfaction with their decision [57].…”

Section: Psychological Variablesmentioning

confidence: 79%

Predictors of choosing life-long screening or prophylactic surgery in women at high and moderate risk for breast and ovarian cancer

2008

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The aim of this study is to summarize published empirical data describing the predictors of adhering to screening practices and choosing to have prophylactic surgery in women at increased risk for breast and ovarian cancer. Pubmed, Psychinfo and Cinahl databases were searched to identify studies on the predictors of adherence to breast and ovarian cancer screening and predictors of having a prophylactic mastectomy or salpingo-oophorectomy. We found 37 empirical studies that met our inclusion criteria. The main predictors of the use of preventive measures are related to DNA test results, socio-demographic characteristics, and psychological outcome measures. It is concluded that there is no unequivocal relationship between age, education, risk perception, or anxiety and adherence to breast and ovarian cancer screening practices. Worrying about cancer is associated with a higher adherence to screening practices.

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Psychological Impact of Prophylactic Oophorectomy in Women at Increased Risk of Developing Ovarian Cancer: A Prospective Study

Cited by 72 publications

References 27 publications

Factors Associated with Altered Long-Term Well-Being After Prophylactic Salpingo-Oophorectomy Among Women at Increased Hereditary Risk for Breast and Ovarian Cancer

Factors Associated with Altered Long-Term Well-Being After Prophylactic Salpingo-Oophorectomy Among Women at Increased Hereditary Risk for Breast and Ovarian Cancer

Screening and preventive behaviors one year after predictive genetic testing for hereditary nonpolyposis colorectal carcinoma

Predictors of choosing life-long screening or prophylactic surgery in women at high and moderate risk for breast and ovarian cancer

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