Psychological insulin resistance in patients with type 2 diabetes mellitus

Shafei, M. M.; Sayyah, Hala E.; Hussein, Rania Elsayed

doi:10.4103/1110-1105.153794

Cited by 13 publications

(14 citation statements)

References 6 publications

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“…The prevalence of PIR in our study was close to the 42%, 40% and 47.2% reported in the studies conducted, respectively, in Bangladesh, 13 the United States 14 and Egypt. 15 This prevalence is lower than 51%, 53.29%, 70.6% and 72% found in Asia. 16,17,18,19 On the other hand, it is higher than 27%, 28% and 33% reported by European authors.…”

Section: Discussionmentioning

confidence: 75%

Prevalence and determinants of psychological insulin resistance among type 2 diabetic patients in Kinshasa, Democratic Republic of Congo

Rita

Lubaki

Bompeka

et al. 2019

Afr. j. prim. health care fam. med.

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Background: Psychological insulin resistance (PIR) is a common but unappreciated phenomenon by health care providers with a negative impact on the control of type 2 diabetes mellitus.Aim: To determine the frequency of PIR and its determinants in patients with type 2 diabetes.Setting: This study was conducted in Kinshasa in three health centres providing management of diabetic patients.Methods: This study was a multicentric, cross-sectional study conducted from 01 November 2017 to 31 March 2018 in Kinshasa among 213 type 2 diabetic patients who were taking oral anti-diabetic drugs. A standardised questionnaire, the Chinese Attitudes to Starting Insulin Questionnaire (Ch-ASIQ), was used for data collection.Results: The average age of participants was 59.8 ± 11.1 years with a male to female ratio of 1.5. The prevalence of PIR was 42.7%; and its main determinants were 50 years of age (odds ratios [OR] adjusted 2.05; 95% confidence interval [CI] 1.98–4.27; p = 0.045), the presence of complications (OR adjusted 3.33; 95% CI 1.68–6.60; p = 0.001), lack of knowledge about insulin therapy (OR adjusted 1.96; 95% CI 1.03–3.71; p = 0.040) and the high cost of insulin (OR adjusted 2.32; 95% CI 1.08–4.95; p = 0.030).Conclusion: The study showed that almost half of type 2 diabetic patients had PIR with the main determinant factors related to the patient and the health system. The establishment of a therapeutic education programme, improved ‘provider–patient’ communication and the development of approaches to increase access to drugs are crucial to reduce the prevalence of PIR.

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Section: Discussionmentioning

confidence: 75%

Prevalence and determinants of psychological insulin resistance among type 2 diabetic patients in Kinshasa, Democratic Republic of Congo

Rita

Lubaki

Bompeka

et al. 2019

Afr. j. prim. health care fam. med.

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“…However, the majority of these patients (67.3%) did not recall having a discussion about insulin treatment with their case doctor in the previous 6 months. When all of the participants were included, the mean total ITAS score was 36.6 (standard deviation 9.5, range 12-59), the mean negative-scale score was 50.6 (standard deviation 9.2, range 27-73) and the mean positive-scale score was 13.9 (standard deviation 2.1, range [7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Other Resultsmentioning

confidence: 99%

“…The ITAS has been used by researchers worldwide to understand PIR in different populations (e.g., in primary care in Amsterdam, in Egypt, in a German geriatric population and in Romania), to study the relationship of PIR with depression and to investigate changes in PIR after the use of different types of insulin or insulin delivery methods, or after specific programs (e.g., team approaches involving diabetes nurses/endocrinologists). The ITAS has been found to be sensitive to changes in PIR throughout the course of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Translation and validation of the Insulin Treatment Appraisal Scale in Hong Kong primary care patients

Lee

2017

J of Diabetes Invest

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Aims/IntroductionPatients with type 2 diabetes mellitus often delay the initiation or titration of insulin treatment due to psychological factors. This phenomenon is referred to as psychological insulin resistance (PIR). The Insulin Treatment Appraisal Scale (ITAS) is a 20‐item instrument for assessing PIR. A previous Chinese version of the ITAS (C‐ITAS) was found to be subject to problems arising from its translation. The present study aimed to translate and validate this instrument, which will facilitate research and aid in counseling in a clinical setting.Materials and MethodsThe C‐ITAS was modified to develop the Hong Kong version of the C‐ITAS (C‐ITAS‐HK) according to published guidelines for the translation of transcultural research. A total of 328 diabetes mellitus patients who were followed‐up in 10 different publically funded primary care outpatient clinics were recruited for self‐administration of the C‐ITAS‐HK. Demographic data were recorded, and clinical data (e.g., presence of diabetes mellitus complications) were obtained from case records. The C‐ITAS‐HK results were subjected to psychometric analysis, including the assessment of Cronbach's alpha, factor analysis and test–retest reliability.ResultsFactor analysis supported a two‐factor structure with good internal consistency (whole scale 0.846, negative subscale 0.882, positive subscale 0.619). The test–retest reliability correlation coefficients for all items were positive, at 0.871, 0.782, and 0.692 for the whole scale, negative subscale and positive subscale, respectively. The ITAS scores differed significantly between participants with PIR and those without in the expected direction, suggesting good discriminant validity.ConclusionsThe C‐ITAS‐HK is a valid tool for measuring and assessing PIR in the Hong Kong primary care diabetes mellitus population.

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“…These findings are summarized in Figures 4, 5, and 6. levosimendan significantly reduced cardiac tissue injury compared to the CLP and vehicle groups, the histopathological damage scores for the levosimendan group were usually nearly normal to mild. These cardioprotective effects of levosimendan may be related to its antiinflammatory effect as a potent inhibitor for different MAPK kinase pathways such as ERK and p38MAPK as well as the Rho kinase pathway inhibition [25, [29][30][31][32][33].…”

Section: The Effects Of Levosimendan Sepsis-induced Histopathological...mentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Psychological insulin resistance in patients with type 2 diabetes mellitus

Cited by 13 publications

References 6 publications

Prevalence and determinants of psychological insulin resistance among type 2 diabetic patients in Kinshasa, Democratic Republic of Congo

Prevalence and determinants of psychological insulin resistance among type 2 diabetic patients in Kinshasa, Democratic Republic of Congo

Translation and validation of the Insulin Treatment Appraisal Scale in Hong Kong primary care patients

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