Psychological interventions for cystic fibrosis

Alleviation of depression-like behavior in a cystic fibrosis mouse model by Hdac6 depletion

“…Anxiety and depression are significant clinical manifestations that adversely affect CF patient quality of life [6][7][8] . It has been shown that CF mouse models also exhibit anxiety-like behavior qualities suggesting that there is a biological, mechanistic reason for behavior manifestations in addition to the stresses of chronic disease that can contribute to anxiety and depression 13 .…”

Health-related quality of life in adults with cystic fibrosis: The role of coping

“…The authors point out that psychosocial interventions built on a coping approach offer a unique contribution to chronic disease management because there is emphasis on the ongoing adaptive processes that people with chronic disease have to confront [52]. Although the importance of providing psychosocial care is recognized and psychosocial interventions have been shown to improve HRQoL in chronic disease populations [53][54][55], there is, as yet, an insufficient evidence base for psychosocial interventions in CF [56]. Further understanding of the psychosocial variables that contribute to HRQoL in CF may enable the development of specific interventions to improve it.…”

Prevalence and impact of depression in cystic fibrosis

“…The potential application of psychotherapy interventions for depressed patients with CF have been well described, [87] but no formal evaluation of these interventions has yet occurred [88]. In a review of these interventions, Duff [87] describes the usefulness of CBT and family therapy to address both depression and anxiety, as well as problems related to adherence.…”