Psychological morbidities and fatigue in patients with confirmed COVID-19 during disease outbreak: prevalence and associated biopsychosocial risk factors

Qi, Rongfeng; Chen, W; S, Liu; Thompson, Paul M.; Lj, Zhang; Xia, Fang; Cheng, Fan; Hong, Anna; Surento, Wesley; Luo, Shanhong; Sun, Ziyong; Zhou, CS; L, Li; X, Jiang; Gm, Lu

doi:10.1101/2020.05.08.20031666

Cited by 76 publications

(105 citation statements)

References 39 publications

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“…We included 31 studies 43,44,[70][71][72][73][74][75] with 5153 patients in our analysis, including two preprint articles 43,93 (see Fig. 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Twenty-seven (87%) studies 43,44,[70][71][72][73][85][86][87][88][89][90][91][92][93][94][96][97][98][99][100][101][102][103][104][105]107 were conducted in China, and the remaining four studies were, respectively, conducted in Italy, 75 Ecuador, 95 Turkey, 74 and Iran. 106 Twenty-eight (90%) studies were cross-sectional studies, 43,44,[70][71][72][73][74][75][85][86][87][88]90,[92][93][94][95][96][97][98]…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

Deng

Zhou

Hou

et al. 2020

Annals of the New York Academy of Sciences

630

499

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Evidence from previous coronavirus outbreaks has shown that infected patients are at risk for developing psychiatric and mental health disorders, such as depression, anxiety, and sleep disturbances. To construct a comprehensive picture of the mental health status in COVID-19 patients, we conducted a systematic review and randomeffects meta-analysis to assess the prevalence of depression, anxiety, and sleep disturbances in this population. We searched MEDLINE, EMBASE, PubMed, Web of Science, CINAHL, Wanfang Data, Wangfang Med Online, CNKI, and CQVIP for relevant articles, and we included 31 studies (n = 5153) in our analyses. We found that the pooled prevalence of depression was 45% (95% CI: 37-54%, I 2 = 96%), the pooled prevalence of anxiety was 47% (95% CI: 37-57%, I 2 = 97%), and the pooled prevalence of sleeping disturbances was 34% (95% CI: 19-50%, I 2 = 98%). We did not find any significant differences in the prevalence estimates between different genders; however, the depression and anxiety prevalence estimates varied based on different screening tools. More observational studies assessing the mental wellness of COVID-19 outpatients and COVID-19 patients from countries other than China are needed to further examine the psychological implications of COVID-19 infections.

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“…We included 31 studies 43,44,[70][71][72][73][74][75] with 5153 patients in our analysis, including two preprint articles 43,93 (see Fig. 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

Deng

Zhou

Hou

et al. 2020

Annals of the New York Academy of Sciences

630

499

View full text Add to dashboard Cite

show abstract

“…There is also the risk of Intensive care unit-acquired weakness (ICUAW), which can result in severe long-lasting disability [75]. In addition, fatigue is emerging as a particular problem, both for those who have milder forms of the disease and those who have had disease warranting intensive care treatment [91,92,93]. Although too soon to be formally diagnosed as chronic fatigue syndrome there are growing reports of symptoms similar to Myalgic encephalomyelitis (ME) as part of a post-viral response, with a similar picture to those seen in previous epidemics [94,95].…”

Section: Longer Term Health Implications For Menmentioning

confidence: 99%

Men and COVID-19: the aftermath

White

2020

Postgraduate Medicine

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The global pandemic as a result of the SARS-CoV2 virus has seen over 16 m people infected and over 650,000 deaths, with men at double the risk of both developing the severe form of the disease and mortality. There are both biological (sex) and socio-cultural (gender) factors, compounded by socioeconomic factors and ethnicity, that impact on the aftermath of what has occurred over the short time that this novel coronavirus has been circulating the world. The potential lifelong morbidity as a result of the infection and as a consequence of highly invasive critical care treatment needs to be factored into the rehabilitation of survivors. There are also many men whose lives will have been severely affected both physically and emotionally by the pandemic without ever contracting the disease, with the widespread disruption to normal existence and its impact on their social world and the economy. The implications of the closure of many healthcare services over the initial lockdown will also have both a shorter-and longer-term impact on other diseases due to missed early diagnosis and disrupted treatment regimes. Getting effective public health messages out to the population is critical and this current pandemic is demonstrating that there needs to be a more focused view on men's health behavior. Without effective public support for preventative action, the more likely the disease will continue its path unabated. This review explores the wider ramifications of the disease both for those men who have survived the disease and those that have been affected by the wider social effects of the pandemic. The pandemic should be a wake-up call for all involved in the planning and delivery of health and social care for the greater attention to the central role of sex and gender.

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“…The patient could rate each question from 0 to 3 to provide a severity score ranging from 0 to 27. We de ned depression severity as being no depression (1-4), mild depression (5-9), moderate depression (10)(11)(12)(13)(14), moderately severe depression (15)(16)(17)(18)(19), and severe depression (20)(21)(22)(23)(24)(25)(26)(27). We considered signi cant depression to be present when the total score was 10 or higher.…”

Section: Methodsmentioning

confidence: 99%

“…When data for patients with COVID-19 was examined, there were cases of such neurological problem as delirium, dysexecutive syndrome, hypoxic encephalopathy, and encephalitis [13]. Psychological morbidities, including PTSD, anxiety, and depression, were reported to be common in COVID-19 patients [12]. Additionally, immune function changes correlated with self-reported depression during short-term follow-up of COVID-19 patients following discharge from the hospital [19].…”

Section: Introductionmentioning

confidence: 99%

Predictors of Psychiatric Disorders or uses of Psychotropic Drugs in Patients with Confirmed COVID-19 During Treatment in a Hospital : A Retrospective Chart Review Running title : Mental health of COVID-19 patients

Kim

Han

Lee

2020

Preprint

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BackgroundThis study aims to examine the psychiatric diagnoses, psychotropic drug use, and related factors in patients with coronavirus disease-19 (COVID-19) during their acute treatment phase.MethodsWe performed a retrospective chart review of patients admitted to the isolation ward at a nationally designated hospital during the COVID-19 outbreak. All the COVID-19 patients admitted to the hospital were assigned to psychiatrists by consultation in order to monitor their mental health during their hospital stay. We analyzed the medical records and self-reported psychological tests of 80 out of 112 patients.ResultsOn admission, 16.3% of the subjects had self-reported depression and 6.3% had post-traumatic stress disorder (PTSD). Twenty-five patients (31.3%) had current diagnoses of mental disorders. These disorders consisted of nonorganic insomnia, acute stress reaction, panic disorder, and depressive episodes. Nineteen patients (23.8%) were prescribed psychotropic drugs, including trazodone, alprazolam, clonazepam, and zolpidem. Factors associated with these psychiatric diagnoses included self-reported PTSD on the day of admission and having a spouse. Previous psychiatric history and age of 40 years or more were associated with the use of psychotropic drugs.ConclusionMental health services rendered to quarantined COVID-19 patients undergoing an acute treatment phase and self-reported PTSD on the day of admission might be useful in predicting mental health problems during hospital days.

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Psychological morbidities and fatigue in patients with confirmed COVID-19 during disease outbreak: prevalence and associated biopsychosocial risk factors

Cited by 76 publications

References 39 publications

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

The prevalence of depression, anxiety, and sleep disturbances in COVID‐19 patients: a meta‐analysis

Men and COVID-19: the aftermath

Predictors of Psychiatric Disorders or uses of Psychotropic Drugs in Patients with Confirmed COVID-19 During Treatment in a Hospital : A Retrospective Chart Review Running title : Mental health of COVID-19 patients

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