Psychological stress and cancer

Soung, Nak-Kyun; Kim, Bo Yeon

doi:10.1186/s40543-015-0070-5

Cited by 31 publications

(19 citation statements)

References 78 publications

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“…Of the many prolonging psychological impacts of cancer, stress is one associated with its growth and progression. [ 16 ] It is also closely associated with other psychological comorbidities such as anxiety and depression. [ 15 ] Studies have indicated the improvement of patients' prognosis by enhancing their immune system while alleviating stress through psychological interventions.…”

Section: Discussionmentioning

confidence: 99%

Stress and Quality of Life in Cancer Patients: Medical and Psychological Intervention

Barre¹,

Padmaja

Rana

et al. 2018

Indian Journal of Psychological Medicine

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Background: Cancer pervades many dimensions of an individual's life – demanding a holistic treatment approach. However, studies with combined medical and psychological interventions (MPIs) are sparse. High-level stress and poor quality of life (QoL) can hinder patients' prognosis. The study thus aimed to analyze the impact of combined medical and psychological (psychoeducation, relaxation technique–guided imagery, and cognitive therapy) interventions on stress and QoL of cancer patients – head and neck, breast, and lung cancers. Methods: The study was conducted in cancer hospitals employing one-group pretest-posttest-preexperimental design. Descriptive statistics, paired t -test, Cohen's d, and bar graphs were used to analyze the data. Results: Findings showed high impact of the combined MPIs in reducing both the overall stress as well as the various components of the stress scale-fear, psychosomatic complaints, information deficit, and everyday life restrictions. Significant changes were also seen in QoL and its domains – global health status, besides functional and symptom scales. Results showed a significant improvement in physical, role and emotional functioning scale, while decrement in fatigue, pain, insomnia, appetite loss, diarrhea, and constipation of symptoms scales. Conclusions: It can be concluded that combined MPI has a positive impact – decreasing stress and improving QoL in cancer patients, which can further enhance their prognosis.

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Section: Discussionmentioning

confidence: 99%

Stress and Quality of Life in Cancer Patients: Medical and Psychological Intervention

Barre¹,

Padmaja

Rana

et al. 2018

Indian Journal of Psychological Medicine

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“…For example, low socioeconomic status, a known chronic stress factor, is linked to increased cancer incidence for some cancer types, but not all ( Clegg et al, 2009 ). Several potential mechanisms for stress-related cancer induction have been proposed, usually linking stress- and depression related CNS activity to immune responses and HPA-axis regulated hormonal secretion ( Soung and Kim, 2015 ; Shin et al, 2016 ). In support of the proposed links between psychological stress and cancer, a recently published prospective cohort study found that adolescent psychological stress resilience was associated with adult cancer occurrence, even after adjusting for socioeconomic circumstances in childhood, and cognitive and physical fitness ( Kennedy et al, 2017 ).…”

Section: Applying the Model: Neurodegenerative Disease And Cancermentioning

confidence: 99%

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

2018

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There is evidence that accumulated senescent cells drive age-related pathologies, but the antecedents to the cellular stressors that induce senescence remain poorly understood. Previous research suggests that there is a relationship between shorter telomere length, an antecedent to cellular senescence, and psychological stress. Existing models do not sufficiently account for the specific pathways from which psychological stress regulation is converted into production of reactive oxygen species. We propose the neuro-immuno-senescence integrative model (NISIM) suggesting how vagally mediated heart rate variability (HRV) might be related to cellular senescence. Prefrontally modulated, and vagally mediated cortical influences on the autonomic nervous system, expressed as HRV, affects the immune system by adrenergic stimulation and cholinergic inhibition of cytokine production in macrophages and neutrophils. Previous findings indicate that low HRV is associated with increased production of the pro-inflammatory cytokines IL-6 and TNF-α. IL-6 and TNF-α can activate the NFκB pathway, increasing production of reactive oxygen species that can cause DNA damage. Vagally mediated HRV has been related to an individual’s ability to regulate stress, and is lower in people with shorter telomeres. Based on these previous findings, the NISIM suggest that the main pathway from psychological stress to individual differences in oxidative telomere damage originates in the neuroanatomical components that modulate HRV, and culminates in the cytokine-induced activation of NFκB. Accumulated senescent cells in the brain is hypothesized to promote age-related neurodegenerative disease, and previous reports suggest an association between low HRV and onset of Alzheimer’s and Parkinson’s disease. Accumulating senescent cells in peripheral tissues secreting senescence-associated secretory phenotype factors can alter tissue structure and function which can induce cancer and promote tumor growth and metastasis in old age, and previous research suggested that ability to regulate psychological stress has a negative association with cancer onset. We therefore conclude that the NISIM can account for a large proportion of the individual differences in the psychological stress-related antecedents to cellular senescence, and suggest that it can be useful in providing a dynamic framework for understanding the pathways by which psychological stress induce pathologies in old age.

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“…Stress can alter sleep patterns and lead to behavioral changes that further influence health, such as using drugs or tobacco or using excessive amounts of alcohol or caffeine 22 . Physical illnesses associated with or exacerbated by stress, include asthma, 23 gastroesophageal reflux disease, 24 irritable bowel syndrome, 25 peptic ulcer disease, 26 coronary artery disease, 27 myocardial infarction, 28 and cancer 29 . Chronic stress and psychological distress may also result in physical pain or other illness such as depression and anxiety 30 , 31 .…”

Section: Complex Emergencies and Their Consequences On Health Professmentioning

confidence: 99%

The Importance of Mental Well-Being for Health Professionals During Complex Emergencies: It Is Time We Take It Seriously

Surya

Jaff

Stilwell

et al. 2017

Glob Health Sci Pract

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We call on humanitarian aid organizations to integrate proven mental health strategies to protect the mental health of their workforce and improve staff capacity to provide care for vulnerable populations. Such strategies could include: Pre-deployment trainingArt therapyTeam buildingPhysical exerciseMindfulness or contemplative techniquesMind-body exercisesNarrative Exposure TherapyEye movement desensitization and reprocessing

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Psychological stress and cancer

Cited by 31 publications

References 78 publications

Stress and Quality of Life in Cancer Patients: Medical and Psychological Intervention

Stress and Quality of Life in Cancer Patients: Medical and Psychological Intervention

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

The Importance of Mental Well-Being for Health Professionals During Complex Emergencies: It Is Time We Take It Seriously

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