Psychological symptoms in Multiple Sclerosis and the role of marital status: results from a retrospective single-center study

Lo Buono, Viviana; Corallo, Francesco; Bonanno, Lilla; Pria, Deborah; Di Cara, Marcella; Palmeri, Rosanna; D'Aleo, Giangaetano; Rifici, Carmela; Sessa, Edoardo; Marino, Silvia; De Cola, Maria Cristina

doi:10.1016/j.msard.2023.105051

Cited by 1 publication

(1 citation statement)

References 38 publications

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“…According to our findings, functional activity negatively predicts the criterion, meaning that higher functional activity is associated with a lower presence of depression and anxiety, with a slightly higher weight than that shown by prefrontal alterations (β = −0.18). This result confirms recent observations in the study by Lo Buono V et al [62], where functional activity was identified as a significant predictor for anxiety and depression subscales, among others, as observed using the Symptoms Checklist-90-Revised (SCL-90-R) questionnaire. However, these findings are not aligned with those obtained by Alswat et al [63], where no association was observed between functional activity and the presence of depression and anxiety in patients with MS from Saudi Arabia.…”

Section: Functional Activitysupporting

confidence: 92%

Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment

Cuerda-Ballester,

Bustos,

Sancho-Cantus

et al. 2024

Bioengineering

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Multiple Sclerosis (MS) is a neurodegenerative disease characterized by motor and non-motor symptoms, including emotional distress, anxiety, and depression. These emotional symptoms currently have a pharmacological treatment with limited effectiveness; therefore, it is necessary to delve into their relationship with other psychological, functional, or prefrontal alterations. Additionally, exploring non-pharmacological therapeutic alternatives that have shown benefits in addressing emotional distress in MS patients is essential. Aim: To establish a predictive model for the presence of anxiety and depression in MS patients, based on variables such as psychological well-being, functional activity, and prefrontal symptoms. Additionally, this study aimed to propose non-pharmacological therapeutic alternatives based on this model. Materials and Methods: A descriptive, observational, and cross-sectional study was conducted with a sample of 64 diagnosed MS patients who underwent functional and cognitive assessments using the following questionnaires and scales: Functional Activities Questionnaire (FAQ), Acceptance and Action Questionnaire (AAQ-II), Experiences Questionnaire (EQ), Self-Compassion Scale Short Form (SCS-SF), Beck Depression Inventory II (BDI-II), State-Trait Anxiety Inventory (STAI), and Prefrontal Symptoms Inventory (PSI). Results: The model showed an excellent fit to the data and indicated that psychological well-being was the most significant predictor of the criteria (β = −0.83), followed by functional activity (β = −0.18) and prefrontal symptoms (β = 0.15). The latter two are negatively related to psychological well-being (β = −0.16 and β = −0.75, respectively). Conclusions: Low psychological well-being is the variable that most significantly predicts the presence of anxiety and depression in MS patients, followed by functional activity and prefrontal alterations. Interventions based on mindfulness and acceptance are recommended, along with nutritional interventions such as antioxidant-enriched ketogenic diets and moderate group physical exercise.

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Section: Functional Activitysupporting

confidence: 92%