Psychological theories of hippocampal function

Schmajuk, Néstor A.

doi:10.3758/bf03332187

Cited by 94 publications

(32 citation statements)

References 68 publications

(132 reference statements)

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“…For example, the work of Kim and Fanselow (1992) and Anagnostaris et al (1999) employed a fearconditioning paradigm to show a recent memory loss for contextual information. Inasmuch as contextual processing has reliably been shown to depend on the hippocampus in anterograde studies (Good & Bannerman, 1997;Good & Honey, 1991;Schmajuk, 1984), it is reasonable to expect amnesia for similar types of information in a retrograde paradigm (e.g., Anagnostaris et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

The effects of lesions to the rat hippocampus or rhinal cortex on olfactory and spatial memory: Retrograde and anterograde findings

Kaut

Bunsey

2001

Cognitive, Affective, & Behavioral Neuroscience

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Section: Discussionmentioning

confidence: 99%

The effects of lesions to the rat hippocampus or rhinal cortex on olfactory and spatial memory: Retrograde and anterograde findings

Kaut

Bunsey

2001

Cognitive, Affective, & Behavioral Neuroscience

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“…Lesion studies have revealed a number of behavioral processes for which the integrity of the hippocampus is critical, most prominently, tasks that require processing of spatial information (O'Keefe and Nadel, 1978: Olton et al, 1979: Chozick, 1983: Morris, 1983Schmajuk, 1984), while hippocampal lesion effects related to so-called nonspatial behavior have been reported less frequently but fairly regularly (Gray, 1982;Schmajuk, 1984;Rawlins, 1985;Tonkiss et al, 1988: Sutherland et a]., 1989Jagielo et al, 1990). The data from these correlational studies are congruent with lesion data in revealing an important involvement of hippocampal circuitry in swimming navigation, particularly in its purest form: reversal learning and crossing over the former platform location.…”

Section: Functional Implicationsmentioning

confidence: 99%

Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse

et al. 1991

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The extent of the infrapyramidal mossy fiber projection in CA3 (IIP-MF) at the midseptotemporal level correlates negatively with two-way avoidance learning and positively with performance in the radial maze, both tasks known to be sensitive to hippocampal lesions. If hippocampal structural variations are causing behavioral variations, one must predict positive correlations between the extent of the IIP-MF and performance in swimming navigation. Thus, the authors studied learning and reversal learning of swimming navigation in mice in which the size of the IIP-MF had been randomized by means of systematic crosses and in 2 mouse strains known for differential infrapyramidal projections (C57BL/6 and DBA/2). In 19 random-bred mice (9 male, 10 female), the extent of the IIP-MF showed negative correlations with swimming time after platform reversal (day 4: r = -0.50, P < .03; day 5 r = -0.73, P < .001), but none during acquisition of the task. In addition, statistical analysis suggested an influence of asymmetrically distributed mossy fiber projections during reversal learning. The strain comparison between 18 DBA/2 and 16 C57BL/6 male mice confirmed these results: no strain difference during days 1-3, and a significantly faster swimming time in the strain C57BL/6 (with large IIP-MF) at day 5 (second day of reversal), associated with significantly more crossings of the former platform location during the early phases of reversal learning. This latter measure was also negatively correlated with asymmetry of the IIP-MF in both strains. Finally, variations of the IIP-MF were correlated partially with adjustment of swimming speed that appeared to depend on size and asymmetry of CA4 as well. Thus, natural variations in the size of the IIP-MF distribution, and, perhaps, of CA4, appear to linearly influence processes directly involved in complex spatial learning.

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“…Such a view conforms to the emerging computational view of distributed neural representation [10] [11]. The hippocampus function could better be described in terms of computational-representational activity, e.g., analyzing, synthesizing, comparing, storing, detecting and encoding the representations of different events [12]. The computational view of the hippocampus raises the question of neural code for the sensory information processing.…”

Section: Introductionmentioning

confidence: 83%

Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing

Bâ¹

2015

JBBS

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Background: This work aims at investigating the histology of hippocampus formation as structural model of information processing. The study addressed the question whether the pattern of cellular type distribution within hippocampal fields could be used as support of information processing in the hippocampus. Method: Pyramidal-shaped neurons presenting both cytoplasm and nucleus outlined clearly were measured systematically on brain slides, using a light microscope connected to a microcomputer equipped with a scanner software for measuring particles. Morphological types of cells were identified following class sizes and their distribution determined through hippocampal fields. Results: A battery of statistical tests: Sturges' classification, class sizes distribution around overall mean, Bartlett's sphericity test, principal components analysis (PCA) followed by correlations matrix analysis and ANOVA allowed two cellular groups to be identified in the hippocampus: large and small pyramidal-shaped cells. Conclusion: The results show that sensory information processing in the hippocampus could be built on two classes of pyramidal neurons that differed anatomically with probably different physiological functions. The study suggests combination ensembles clustering large and small pyramidal cells at different rates, as fundamental signaling units of the hippocampus.

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Psychological theories of hippocampal function

Cited by 94 publications

References 68 publications

The effects of lesions to the rat hippocampus or rhinal cortex on olfactory and spatial memory: Retrograde and anterograde findings

The effects of lesions to the rat hippocampus or rhinal cortex on olfactory and spatial memory: Retrograde and anterograde findings

Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse

Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing

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