Objective: Associations of specific types of stress with increased food intake and subsequent weight gain have been demonstrated in animal models as well as in experimental and epidemiological studies on humans. This study explores the research question of to what extent potentially obesity-related factors determine perceived stress in individuals with obesity. Methods: N = 547 individuals with obesity participated in a cross-sectional study assessing perceived stress as the outcome variable and potential determinants of stress related to obesity. Based on the available evidence, a five factorial model of ‘obesity-related obesogenic stressors' was hypothesized, including the dimensions, ‘drive for thinness', ‘impulse regulation', ‘ineffectiveness', ‘social insecurity', and ‘body dissatisfaction'. The model was tested using multiple linear regression analyses. Results: The five factorial model of ‘potentially obesity-related stressors' resulted in a total variance explanation of adjusted R² = 0.616 for males and adjusted R² = 0.595 for females for perceived stress. The relative variance contribution of the five included factors differed substantially for the two sexes. Conclusion: The findings of this cross-sectional study support the hypothesized, potentially obesity-related factors: ‘drive for thinness', ‘impulse regulation', ‘ineffectiveness', ‘social insecurity', and ‘body dissatisfaction' as relevant determinants of perceived stress in individuals with obesity.