Following a suicide attempt by female adolescents, the impact of a specialized emergency room (ER) care intervention was evaluated over the subsequent 18 months. Using a quasi-experimental design, this study assigned 140 female adolescent suicide attempters (SA), ages 12-18 years, and their mothers (88% Hispanic) to receive during their ER visit either: (a) specialized ER care aimed at enhancing adherence to outpatient therapy by providing a soap opera video regarding suicidality, a family therapy session, and staff training; or (b) standard ER care. The adjustment of the SA and their mothers was evaluated over 18 months (follow-up, 92%) using linear mixed model regression analyses. SA's adjustment improved over time on most mental health indices. Rates of suicide reattempts (12.4%) and suicidal reideation (29.8%) were lower than anticipated and similar across ER conditions. The specialized ER care condition was associated with significantly lower depression scores by the SA and lower maternal ratings on family cohesion. Significant interactions of intervention condition with the SA's initial level of psychiatric symptomatology indicated that the intervention's impact was greatest on maternal emotional distress and family cohesion among SA who were highly symptomatic. SA's attendance at therapy sessions following the ER visit was significantly associated with only one outcome-family adaptability. Specialized ER interventions may have substantial and sustained impact over time, particularly for the parents of youth with high psychiatric symptomatology. Adolescent suicide attempts are a significant problem, with 7.7% of high school students reporting attempts and 2.6% saying their attempt required medical attention (Centers for Disease Control and Prevention [CDC], 1998). Adolescent suicide attempters (SA) are at increased risk for repeat attempts, long-term psychiatric symptoms, and academic, social, and behavioral problems (Shaffer & Piacentini, 1994). In spite of their great need for mental health intervention, fewer than 50% of adolescent attempters are referred for psychotherapy following their emergency room (ER) visit (Piacentini et al., 1995; Spirito, Brown, Overholser, & Fritz, 1989), and a large proportion of these individuals fail to attend their initial treatment session. Of those who do attend, many do not complete treatment (Piacentini et al., 1995; Spirito et al., 1989). Nonattendance to follow-up treatment by suicidal adolescents is especially disturbing, considering that psychiatric intervention can reduce subsequent attempts and social maladjustment (Rotheram-Borus, Piacentini, Miller, Graae, & Castro-Bianco, 1994; Shaffer & Piacentini, 1994). There are many reasons why individuals fail to attend treatment following an ER visit for a suicide attempt. Repetitive evaluations, lengthy waiting periods, bureaucratic registration procedures, and