Psychological variables as predictors of rubella antibody titers and fatigue—a prospective, double blind study

Morag, Michal; Morag, Abraham; Reichenberg, Abraham; Lerer, Bernard; Yirmiya, Raz

doi:10.1016/s0022-3956(99)00010-2

Cited by 82 publications

(54 citation statements)

References 25 publications

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“…The negative influence of these context-inappropriate perceptions of stress suggest that personality factors may also be implicated in determining the adequacy of the antibody response. This resonates with the results reported for thymus-dependent vaccinations, in which higher negative affect [40], neuroticism [54], and psychological symptoms [38] are associated with poorer antibody titres, and suggests that conjugate vaccines may be similarly susceptible to psychological influence.…”

Section: Conjugate Vaccinationssupporting

confidence: 87%

“…Among the girls who were seronegative for antibodies against rubella virus, and, therefore, for whom vaccination elicited a primary antibody response, those high in internalising (characterised by withdrawal and anxiety), high in neuroticism (emotional instability), and low in self-esteem had lower antibody titres. In contrast, in the girls who exhibited antibodies against rubella prior to vaccination, for whom this was a secondary response, no relationships between psychological status and immunity were found [54].…”

Section: Thymus-dependent Vaccinationsmentioning

confidence: 84%

“…Several studies have indicated that trait-like measures of stress and anxiety may be better predictors of antibody status than more transient, state-like measures [34,54].…”

Section: Theoretical Studiesmentioning

confidence: 99%

“…Many studies did not control for health behaviours [41,47,50,54,76]; the vast majority of the studies that do [34, 37-39, 44, 53, 56, 57] use less-than-optimal brief retrospective questionnaires. In order to fully address the potential role of health behaviours, more investigators could include detailed day-by-day assessments as were performed in the exemplary study of Pressman and colleagues [52] or objective measures of health behaviours, such as cotinine to assess cigarette smoking.…”

Section: Theoretical Studiesmentioning

confidence: 99%

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Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymusdependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

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Section: Conjugate Vaccinationssupporting

confidence: 87%

Section: Thymus-dependent Vaccinationsmentioning

confidence: 84%

“…Several studies have indicated that trait-like measures of stress and anxiety may be better predictors of antibody status than more transient, state-like measures [34,54].…”

Section: Theoretical Studiesmentioning

confidence: 99%

Section: Theoretical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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“…1). Indeed, there is abundant evidence that chronic stressors directly influence the immune system, including enhanced susceptibility to viral and bacterial infections among individuals exposed during human challenge trials and vaccination (Biondi and Zannino 1997;Bonneau et al 2007;Miller et al 2004;Morag et al 1999). If ecologic stressors, such as concentrated disadvantage and segregation, determine the distribution of psychological stress in a community, then it is likely that stress-related changes in immune function may also vary by neighborhood context.…”

Section: Introductionmentioning

confidence: 99%

Population Levels of Psychological Stress, Herpesvirus Reactivation and HIV

2008

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Nearly 40,000 Americans are newly infected with Human Immunodeficiency Virus (HIV) each year. Recently, studies have demonstrated associations between group-level characteristics and the prevalence and incidence of HIV/Acquired Immune Deficiency Syndrome (AIDS) and other sexually transmitted diseases. Two mechanisms previously posited to explain these associations are neighborhood effects on risk behaviors and social or institutional policies. In this paper, we hypothesize that adversity at the population level, such as neighborhood poverty, also influences HIV risk through stress-mediated aberrations in immunological susceptibility by reviewing existing data examining each of these pathways. In particular, we review the evidence showing that: (1) Neighborhood ecologic stressors influence neighborhood-and individual-levels of mental health, psychosocial stress, and HIV/AIDS risk, (2) Individual-level psychosocial stressors influence progression from HIV to AIDS through stress-related hormonal changes, and (3) Individual-level psychosocial stressors influence HIV acquisition via stress-related reactivation of latent herpesviruses, specifically EBV and HSV-2. Our review indicates that further studies are needed to examine the joint pathways linking neighborhood-level sources of psychosocial stress, stress-related reactivation of HSV-2 and EBV, and increased acquisition rates of HIV. We suggest using a multi-level framework for targeting HIV prevention efforts that address not only behavioral risk factors, but structural, political, and institutional factors associated with neighborhood disadvantage, levels of psychosocial stress, and prevention or treatment of HSV-2 and EBV.

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Psychoneuroimmunology

Stowell

McGuire

Robles

et al. 2003

Handbook of Psychology

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In this chapter, we briefly introduce two major physiological systems that modulate immune function and then provide evidence for stress‐immune relationships in acute and chronic conditions. Next, we explore the psychosocial factors that may be important in moderating and mediating these relationships, including negative affect, social support, and interpersonal relationships. Finally, we review intervention strategies that may be beneficial in reducing the negative effects of stress on the immune system. Basic and applied psychoneuroimmunology research studies have provided an encouraging foundation for characterizing the links between psychosocial and immunological factors. The current knowledge of psychoneuroimmunology with respect to individual psychological differences, emotions, coping strategies, and interpersonal relationships has already had a significant impact on understanding the contribution that the psychosocial context has on immune function, health, and disease. The next wave of research will expand our knowledge of psychosocial factors and their role in the progression of immunologically mediated conditions, including HIV/AIDS, rheumatoid arthritis, certain cancers, and surgical recovery. From this knowledge, we can devise and implement effective interventions to enhance quality of life and improve health.

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Psychological variables as predictors of rubella antibody titers and fatigue—a prospective, double blind study

Cited by 82 publications

References 25 publications

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Population Levels of Psychological Stress, Herpesvirus Reactivation and HIV

Psychoneuroimmunology

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