Occupational health and safety reflects the effect of the work environment on employees, groups and work units in organizations, and organizations as a whole. This chapter provides an overview of the research on workplace safety and specifically discusses safety training, regulatory focus, safety climate, leadership, and job design as they relate to safety. Additionally, the literature on occupational health, drawing heavily on the occupational stress literature, discusses the employee-employer relationship from a psychological contract perspective, including climate for sexual harassment, collective burnout and its contagion, recovery, and organizational wellness programs. Particular attention is given to primary interventions to enhance safety, health, and well-being of employees and to eliminate the harmful effects that may arise through individual characteristics, group/work unit factors, and aspects of the organization.