No studies have described physical therapy treatment for children with congenital Zika virus syndrome. In this case report, the authors aimed to improve postural control, mobility, and social skills in a 17- to 18-month-old child with congenital Zika virus syndrome through a period of 6-week home-based, intensive physical therapy intervention. Outcome measures were the Posture and Postural Ability Scale, Pediatric Evaluation of Disability Inventory, and Caregiver Priorities and Child Health Index of Life With Disabilities. From pre- to postintervention, the child’s Posture and Postural Ability Scale scores increased for level of postural ability in the prone position and postural alignment in all 4 positions (prone, supine, sitting, and standing). The authors saw an overall improvement in mobility and social skills from preintervention to follow-up 3 weeks after intervention. In conclusion, postural control, mobility, and social skills improved for a child with congenital Zika virus syndrome after physical therapy intervention, but future studies are required to confirm these findings.