Psychometric Properties of the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36) in the United States

Peipert, John Devin; Bentler, Peter M.; Klicko, Kristi; Hays, Ron D.

doi:10.1053/j.ajkd.2017.07.020

Cited by 100 publications

(108 citation statements)

References 21 publications

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“…KDQOL-36 is a reliable and valid kidney disease specific measure of HRQOL survey and has been used for evaluation of hemodialysis patients since 2002 [19]. A systematic review by Aiyegbusi et al [20], they suggested the use of KDQOL-36 in hemodialysis patients as a patient-reported outcome measure.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

et al. 2019

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Objectives: Aim of the study was investigating the effect of serum vitamin D levels on health-related quality of life in hemodialysis patients. Method: One-hundred and twenty-three maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients divided into 2 groups according to serum vitamin D levels. A serum 25-hydroxyvitamin D (25[OH] D) level of < 20 ng/mL was identified as vitamin D deficiency (n = 78), and a serum level of ≥20 ng/mL was identified as normal (n = 45). Kidney Disease Quality of Life 36 (KDQOL-36) survey was used for quality of life measurement. Scores of the all of 5 subscales of KDQOL-36 were calculated. Multiple linear regression analyses were used to define independent risk factors affecting the survey. Results: Mean age of patients was 62 and 56% of patients were male. Mean 25(OH) D levels were 11.86 and 29.57 ng/mL, respectively, in 2 groups. There was statistically significant difference between age and Kt/V levels between 2 groups (p = 0.008 and p = 0.041). Age and gender were found as significant predictors of vitamin D deficiency (p = 0.026 and p = 0.021). In symptom and problem list subscale, gender and comorbidity were detected as independent risk factors (p = 0.050 and p = 0.032). Comorbidity was the only independent risk factor for effect of kidney disease subscale (p < 0.001). Independent risk factors associated with burden of kidney disease subscale were comorbidity and serum 25 (OH) D levels (p = 0.003 and p = 0.023). Serum 25(OH) D, gender, and comorbidity were independently associated with physical component summary (PCS) subscale (p < 0.001, p = 0.008, and p = 0.011). The only independently associated factor with mental component summary (MCS) was serum 25(OH) D (p < 0.001). Conclusion: We first showed the relationship between serum vitamin D levels and KDQOL-36 in hemodialysis patients. Lower serum vitamin D levels were negatively associated with burden of kidney disease, PCS, and MCS subscales.

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Section: Discussionmentioning

confidence: 99%

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

et al. 2019

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“…The most commonly administered symptom PROM, the KDQOL™ symptom subscale, relies on a 4-week recall period, rendering it impossible to link symptoms to specific treatment characteristics. [11, 29, 30] Furthermore, the KDQOL™ is administered relatively infrequently, often only annually among prevalent patients. The Dialysis Symptom Index (DSI) assesses bother of 30 physical and mood symptoms with a recall period of one week.…”

Section: Discussionmentioning

confidence: 99%

“…In most U.S. dialysis clinics, systematic symptom data are captured using the Kidney Disease Quality of Life (KDQOL™) symptom subscale, a scale that evaluates symptoms over a 4-week period. [11] This recall period precludes the linkage of symptom reports to specific dialysis treatments. A patient-reported outcome measure (PROM) capturing symptoms with a shorter recall period would facilitate investigation of individualized approaches to symptom management.…”

Section: Introductionmentioning

confidence: 99%

Development and content validity of a hemodialysis symptom patient-reported outcome measure

Flythe

Dorough²,

Narendra³

et al. 2018

Qual Life Res

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Symptom Monitoring on Renal Replacement Therapy-Hemodialysis (SMaRRT-HD™) is a 14-item PROM intended for use in hemodialysis patents. SMaRRT-HD™ uses a single treatment recall period and a 5-point Likert scale to assess symptom severity. Qualitative interview data provide evidence of its content validity. SMaRRT-HD™ is undergoing additional testing to assess measurement properties and inform measure scoring.

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“…The centers for Medicare and Medicaid require that all dialysis patients health related quality of life be assessed at least annually (15). The primary instrument for that purpose is the KDQOL-36 whose psychometric properties have construct validity in assessing mental well-being of dialysis patients (16).The questionnaire includes:…”

Section: Methodsmentioning

confidence: 99%

Mental Effects of Excess Parathyroid Hormone in Hemodialysis Patients: A Possible Role for Parathyroid 2 Hormone Receptor?

Diskin

2019

Ther Apher Dial

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Depression as measured by the kidney disease quality of life (KDQOL) form is known to be an independent risk factor for mortality dialysis patients. Excess parathyroid hormone (PTH) has long been associated with neuropsychiatric disturbances. Those psychiatric complications are currently attributed to hypercalcemia with very little evidence; however, with the discovery of the parathyroid hormone 2 receptor (PTH2R) in the brain which can be activated by PTH, PTH2R might indicate a direct effect of PTH. As secondary and tertiary hyperparathyroidism is common in dialysis patients where the serum calcium is low or normal, we chose to investigate a possible relationship between PTH levels and depression in dialysis patients. This was a matched pair observational study with 10 patients with intact PTH values above 1000 pg/mL who were matched with 10 patients who had PTH values less than 400 pg/mL for the presence of diabetes, years on dialysis, duration of dialysis time, Kt/V, hemoglobin, and 25 OH vitamin D levels, as well as intravenous iron and erythropoietin administration. The Kidney Disease Quality of Life questionnaire (KDQOL-36) scores and patient Health Questionnaire scores were analyzed during that time. All variables underwent tests for normality and matched pair t-test. All subscales of the KDQOL-36 were worse in the high PTH group with the effect on daily life reaching P = 0.01 and the burden of disease and symptoms both reaching P = 0.02. PTH and PTH2R may be appropriate targets for investigations to improve the quality of life in hemodialysis patients.

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Psychometric Properties of the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36) in the United States

Abstract: The study provides support for the reliability and construct validity of the KDQOL-36 scales for assessment of health-related quality of life among dialysis patients.

Cited by 100 publications

References 21 publications

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

Development and content validity of a hemodialysis symptom patient-reported outcome measure

Mental Effects of Excess Parathyroid Hormone in Hemodialysis Patients: A Possible Role for Parathyroid 2 Hormone Receptor?

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