In this study, the effect of the perception of spousal support during pregnancy on nausea-vomiting experienced during early pregnancy was investigated. In addition, some factors that may be related to the perception of spousal support during pregnancy and nausea-vomiting experienced during early pregnancy were examined. Material and Methods: The study was cross-sectional. The study was conducted in the outpatient clinic of the gynecology and obstetrics department of a university hospital located in the Central Anatolia region of Türkiye. The sample of the study consisted of 308 pregnant women who came to the gynecology and obstetrics department of the hospital where the study was carried out for examination, were between the 4th-16th gestational weeks, were 19 years of age or older, married and living with their spouses. Data were collected using the Personal Information Form, Pregnancy-Unique Quantification of Emesis (PUQE-24) Scale and Perception of Spousal Support in Pregnancy Scale (PSSPS). Results: The mean age of pregnant women was 27.0±4.2 years. PSSPS total and subscale scores did not differ statistically among PUQE-24 Scale groups (p>0.05). There was a statistically significant difference between income status, duration of marriage, number of living children, pregnancy with assisted reproductive techniques and PSSPS total scores (p<0.05). According to the PUQE-24 Scale groups, no difference was found between the distributions of age, educational background, occupation, income status, duration of marriage, number of living children, planned pregnancy and pregnancy with assisted reproductive techniques (p>0.05). Conclusion: It was found that the perception of spousal support during pregnancy had no effect on mild, moderate or severe nausea-vomiting experienced during early pregnancy. In addition, it was determined whether some factors were related to the perception of spousal support during pregnancy and the nausea-vomiting experienced during early pregnancy. In line with the results obtained from this research, it is important for nurses to inform, provide counseling and plan appropriate interventions on the subject.