Psychometric study of the Neurobehavioral Symptom Inventory

King, Paul R.; Donnelly, Kerry; Donnelly, James P.; Dunnam, Mina; Warner, Gary C.; Kittleson, C. J.; Bradshaw, Charles B.; Alt, Michelle; Meier, Scott T.

doi:10.1682/jrrd.2011.03.0051

Cited by 210 publications

(124 citation statements)

References 19 publications

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“…15 In the present study, TBI participants reported a greater number of post-concussive symptoms based on NSI total scores, which is consistent with the prior TBI literature. 49,50 Further, the area of significant cortical thinning in the TBI population positively correlated with NSI scores, suggesting that post-concussive symptoms are related to right frontotemporal dysfunction. However, the NSI scale is not specific to TBI, since individuals with affective disorders (i.e.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Cortical Thickness after Traumatic Brain Injury in Military Veterans

Michael

Stout

Roskos

et al. 2015

Journal of Neurotrauma

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Military service members frequently sustain traumatic brain injuries (TBI) while on active duty, a majority of which are related to explosive blasts and are mild in severity. Studies evaluating the cortical gray matter in persons with injuries of this nature remain scarce. The purpose of this study was to assess cortical thickness in a sample of military veterans with chronic blast-related TBI. Thirty-eight veterans with mild TBI and 17 veterans with moderate TBI were compared with 58 demographically matched healthy civilians. All veterans with TBI sustained injuries related to a blast and were between 5 and 120 months post-injury (M = 62.08). Measures of post-traumatic stress disorder (PTSD) and depression were administered, along with a battery of neuropsychological tests to assess cognition. The Freesurfer software package was used to calculate cortical thickness of the participants. Results demonstrated significant clusters of cortical thinning in the right hemispheric insula and inferior portions of the temporal and frontal lobe in both mild and moderate TBI participants. The TBI sample from this study demonstrated a high incidence of comorbid PTSD and depression symptoms, which is consistent with the previous literature. Cortical thickness values correlated with measures of PTSD, depression, and post-concussive symptoms. This study provides evidence of cortical thinning in the context of chronic blast-related mild and moderate TBI in military veterans who have comorbid psychiatric symptoms. Our findings provide important insight into the natural progression of long-term cortical change in this population and may have implications for future clinical evaluation and treatment.

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Section: Discussionmentioning

confidence: 91%

Evaluation of Cortical Thickness after Traumatic Brain Injury in Military Veterans

Michael

Stout

Roskos

et al. 2015

Journal of Neurotrauma

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“…A cut-score of 17.5, described by King, was used to indicate clinical significance of total scores. 48 Previous studies indicate that the NSI has good psychometric properties. 28 Other measures.…”

Section: Cognitive Performance Measuresmentioning

confidence: 99%

The Effect of Varied Test Instructions on Neuropsychological Performance following Mild Traumatic Brain Injury: An Investigation of “Diagnosis Threat”

Blaine

Sullivan

Edmed

2013

Journal of Neurotrauma

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Diagnosis threat is a psychosocial factor that has been proposed to contribute to poor outcomes following mild traumatic brain injury (mTBI). This threat is thought to impair the cognitive test performance of individuals with mTBI because of negative injury stereotypes. University students (N = 45, 62.2% female) with a history of mTBI were randomly allocated to a diagnosis threat (DT; n = 15), reduced threat (DT-reduced; n = 15), or neutral (n = 15) group. The reduced threat condition invoked a positive stereotype (i.e., that people with mTBI can perform well on cognitive tests). All participants were given neutral instructions before they completed baseline tests of objective cognitive function across a number of domains, psychological symptoms, and PCS symptoms, including self-reported cognitive and emotional difficulties. Participants then received either neutral, DT, or DT-reduced instructions before repeating the tests. Results were analyzed using separate mixed model analysis of variances (ANOVAs); one for each dependent measure. The only significant result was for the 2 · 3 ANOVA on an objective test of attention/working memory, Digit Span ( p < 0.05), such that the DTreduced group performed better than the other groups, which were not different from each other. Although not consistent with predictions or earlier DT studies, the absence of group differences on most tests fits with several recent DT findings. The results of this study suggest that it is timely to reconsider the role of DT as a unique contributor to poor mTBI outcome.

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“…It has high internal consistency (total α = .95; subscale α = .88-.92) and reliability (r = 0.88-0.93). 17 Symptoms of PTSD were assessed by the PTSD…”

Section: Determination Of Pcd Ptsd and Depression Symptomsmentioning

confidence: 99%

Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment

et al. 2015

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IMPORTANCE Approximately one-third of military personnel who deploy for combat operations sustain 1 or more traumatic brain injuries (TBIs), which increases the risk for chronic symptoms of postconcussive disorder, posttraumatic stress disorder, and depression and for the development of chronic traumatic encephalopathy. Elevated concentrations of tau are observed in blood shortly following a TBI, but, to our knowledge, the role of tau elevations in blood in the onset and maintenance of chronic symptoms after TBI has not been investigated.OBJECTIVES To assess peripheral tau levels in military personnel exposed to TBI and to examine the relationship between chronic neurological symptoms and tau elevations. DESIGN, SETTING, AND PARTICIPANTSObservational assessment from September 2012 to August 2014 of US military personnel at the Madigan Army Medical Center who had been deployed within the previous 18 months. Plasma total tau concentrations were measured using a novel ultrasensitive single-molecule enzyme-linked immunosorbent assay. Classification of participants with and without self-reported TBI was made using the Warrior Administered Retrospective Casualty Assessment Tool. Self-reported symptoms of postconcussive disorder, posttraumatic stress disorder, and depression were determined by the Neurobehavioral Symptom Inventory, the Posttraumatic Stress Disorder Checklist Military Version, and the Quick Inventory of Depressive Symptomatology, respectively. Group differences in tau concentrations were determined through analysis of variance models, and area under the receiver operating characteristic curve determined the sensitivity and specificity of tau concentrations in predicting TBI and chronic symptoms. Seventy participants with self-reported TBI on the Warrior Administered Retrospective Casualty Assessment Tool and 28 control participants with no TBI exposure were included. MAIN OUTCOMES AND MEASURES Concentration of total tau in peripheral blood.RESULTS Concentrations of plasma tau were significantly elevated in the 70 participants with self-reported TBI compared with the 28 controls (mean [SD], 1.13 [0.78] vs 0.63 [0.48] pg/mL, respectively; F 1,97 = 4.97; P = .03). Within the self-reported TBI cases, plasma total tau concentrations were significantly associated with having a medical record of TBI compared with self-reported TBI only (mean [SD], 1.57 [0.92] vs 0.85 [0.52] pg/mL, respectively; F 1,69 = 6.15; P = .02) as well as reporting the occurrence of 3 of more TBIs during deployment compared with fewer than 3 TBIs (mean [SD], 1.52 [0.82] vs 0.82 [0.60] pg/mL, respectively; F 1,69 = 8.57; P = .008). The severity of total postconcussive symptoms correlated with total tau concentrations in the self-reported TBI group (r = 0.37; P = .003). CONCLUSIONS AND RELEVANCEMilitary personnel who report multiple TBIs have long-term elevations in total tau concentration. The total tau concentration relates to symptoms of postconcussive disorder.

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Psychometric study of the Neurobehavioral Symptom Inventory

Cited by 210 publications

References 19 publications

Evaluation of Cortical Thickness after Traumatic Brain Injury in Military Veterans

Evaluation of Cortical Thickness after Traumatic Brain Injury in Military Veterans

The Effect of Varied Test Instructions on Neuropsychological Performance following Mild Traumatic Brain Injury: An Investigation of “Diagnosis Threat”

Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment

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