Psychometric validation of a generic health-related quality of life measure (EQ-5D) in a sample of schizophrenic patients

Abstract

Results suggest the EQ-5D is a valid instrument capable of detecting HRQOL differences between schizophrenic patients with different degrees of severity of illness.

Relative association of treatment‐emergent adverse events with quality of life of patients with schizophrenia: post hoc analysis from a 3‐year observational study

“…Although EQ-VAS is not widely used to assess quality of life in patients with schizophrenia, this instrument has been validated for assessing patients with schizophrenia in naturalistic settings and can discriminate differences in quality of life among patients with varying severity of disease (König et al, 2007;Prieto et al, 2004). Further limitations were associated with the potential for loss of information arising from the way in which the data were collected.…”

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

“…A re-examination of the evidence, taking into account evidence for the type of measure used to assess convergent validity (symptom vs. functioning or HRQoL measures, subjective vs. objective measures), produced mixed results. Functioning and schizophrenia HRQoL measures did not fare much better than clinical and symptom-based measures, with four studies indicating strong evidence for convergent validity, [82][83][84]86 and four indicating uncertain or no evidence of such a relationship.…”

“…Participants included males and females with a mean age of participants with a schizophrenia spectrum disorder, reported in 21 of the 33 studies, ranging between 20.3 and 57.9 years. 48,68,[70][71][72][73][75][76][77][78][79][80]82,84,86,[88][89][90][91]94,95 All studies obtained HRQoL information from patients; seven of these studies compared patient HRQoL values with published general population 'normative' values, [70][71][72][73][74][75][76] three compared HRQoL values with normal comparison participants that were recruited to the study [77][78][79] and two used 'norms' from healthy participants who had taken part in large surveys.…”

“…83 Four studies investigated differences in HRQoL between mood groups in bipolar disorder. 75,[84][85][86] Two of the four studies investigating the EQ-5D used general population preferences for EQ-5D health states to generate EQ-5D index values. 87,96 Personality disorder…”

Clinical and functional outcomes for patients with schizophrenia treated with olanzapine: One-year naturalistic outcomes for inpatients and outpatients in Japan

“…Utility values ranging from death (0) to perfect health (1) are assigned to different health states created from the ratings on the 5 dimensions. The construct validity of the EQ-5D has been evaluated in a sample of individuals with schizophrenia: utility scores were moderately correlated with the PANSS subscales (-.15 to -.67) and the World Health Organization Quality of Life -Brief Questionnaire subscales (.28 to .60) [33]. In addition to the EQ-5D, patients were also asked about their participation in social activities in the past four weeks and employment status.…”