Psychomotor activity in affective states

Kupfer, D. J.; Weiss, BrianL.; Foster, F. G.; Detre, Thomas; Delgado, José M. R.; McPartland, Richard

doi:10.1016/0022-3956(74)90026-0

Cited by 14 publications

(18 citation statements)

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“…Individuals diagnosed with unipolar depression exhibit greater motor activity relative to subjects with BD depression (Kupfer et al, 1974), but demonstrate lower activity compared to BD subjects in a manic state (Weiss et al, 1974). Other groups have reported both increases and decreases in motor activity in depressed subjects (Foster et al, 1978; Teicher et al, 1988).…”

Section: Assessment Of Exploration and Motor Behavior In Psychiatrmentioning

confidence: 99%

“…One report observed that amitriptyline treatment decreased motor activity in a subset of agitated unipolar depressed patients, but had little effect in other subjects (Kupfer et al, 1974). Treatment with lithium also appears to produce inconsistent effects on motor activity in BD mania (Heninger and Kirstein, 1977; Weiss et al, 1974).…”

Section: Assessment Of Exploration and Motor Behavior In Psychiatrmentioning

confidence: 99%

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Cross-species assessments of motor and exploratory behavior related to bipolar disorder

Henry

Minassian

Young

et al. 2010

Neuroscience & Biobehavioral Reviews

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Alterations in exploratory behavior are a fundamental feature of bipolar mania, typically characterized as motor hyperactivity and increased goal-directed behavior in response to environmental cues. In contrast, abnormal exploration associated with schizophrenia and depression can manifest as prominent withdrawal, limited motor activity, and inattention to the environment. While motor abnormalities are cited frequently as clinical manifestations of these disorders, relatively few empirical studies have quantified human exploratory behavior. This article reviews the literature characterizing motor and exploratory behavior associated with bipolar disorder and genetic and pharmacological animal models of the illness. Despite sophisticated assessment of exploratory behavior in rodents, objective quantification of human motor activity has been limited primarily to actigraphy studies with poor cross-species translational value. Furthermore, symptoms that reflect the cardinal features of bipolar disorder have proven difficult to establish in putative animal models of this illness. Recently, however, novel tools such as the Human Behavioral Pattern Monitor provide multivariate translational measures of motor and exploratory activity, enabling improved understanding of the neurobiology underlying psychiatric disorders.

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Section: Assessment Of Exploration and Motor Behavior In Psychiatrmentioning

confidence: 99%

Section: Assessment Of Exploration and Motor Behavior In Psychiatrmentioning

confidence: 99%

Cross-species assessments of motor and exploratory behavior related to bipolar disorder

Henry

Minassian

Young

et al. 2010

Neuroscience & Biobehavioral Reviews

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“…Die Perioden relativer Immobilität nahmen bei unipolar Depressiven im Verlauf der stationären Behandlung ebenso wie die Scores der Hamilton-Depressions-Skala ab. Es konnte gezeigt werden, dass Lithium die motorische Aktivität bipolarer Patienten normalisierte und dass die Tagesaktivität in einer kleinen Gruppe bipolar Depressiver, die auf die Therapie mit Lithium respondierten, erhöht war [21]. Bipolare Patienten unter Lithiumprophylaxe mit einem hohen Rezidivrisiko können durch erhöhte motorische Aktivität während des Tages und zirkadiane Dysregulation der Aktivitätsverteilung identifiziert werden [34].…”

Section: Aktivität Und Therapieeffekteunclassified

“…Bipolare Patienten unter Lithiumprophylaxe mit einem hohen Rezidivrisiko können durch erhöhte motorische Aktivität während des Tages und zirkadiane Dysregulation der Aktivitätsverteilung identifiziert werden [34]. Die Reduktion der motorischen Aktivität durch Amitriptylin ist ein Prä-diktor für das Ansprechen auf die Medikation, während bei Nichtwirksamkeit die Aktivität unter Amitriptylin erhöht ist [21], was mit klinischen Beobachtungen gut im Einklang steht. Mittels Aktigraphie lassen sich differenzielle Effekte von Antidepressiva auf die psychomotorische Aktivität im Behandlungsverlauf nachweisen.…”

Section: Aktivität Und Therapieeffekteunclassified

Aktivität und Depression - Möglichkeiten und Grenzen aktigraphischer Verhaltensanalysen -

Lemke¹,

Mieth²,

Pleuse³

et al. 2001

Psychiatr Prax

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“…Decreased activity in speech (paucity of speech) seems to be a sensitive and valid measure of prodromal symptoms of depression21 22 and conversely increased speech activity (talkativeness) predicts a switch to hypomania 19 23 24. Similarly, social activity,25 that is, engaging in relations to others, as well as physical activity26 27 represents central and sensitive aspects of illness activity in bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Daily electronic self-monitoring of subjective and objective symptoms in bipolar disorder—the MONARCA trial protocol (MONitoring, treAtment and pRediCtion of bipolAr disorder episodes): a randomised controlled single-blind trial

et al. 2013

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IntroductionElectronic self-monitoring of affective symptoms using cell phones is suggested as a practical and inexpensive way to monitor illness activity and identify early signs of affective symptoms. It has never been tested in a randomised clinical trial whether electronic self-monitoring improves outcomes in bipolar disorder. We are conducting a trial testing the effect of using a Smartphone for self-monitoring in bipolar disorder.MethodsWe developed the MONARCA application for Android-based Smartphones, allowing patients suffering from bipolar disorder to do daily self-monitoring—including an interactive feedback loop between patients and clinicians through a web-based interface. The effect of the application was tested in a parallel-group, single-blind randomised controlled trial so far including 78 patients suffering from bipolar disorder in the age group 18–60 years who were given the use of a Smartphone with the MONARCA application (intervention group) or to the use of a cell phone without the application (placebo group) during a 6-month study period. The study was carried out from September 2011. The outcomes were changes in affective symptoms (primary), social functioning, perceived stress, self-rated depressive and manic symptoms, quality of life, adherence to medication, stress and cognitive functioning (secondary and tertiary).AnalysisRecruitment is ongoing.EthicsEthical permission has been obtained.DisseminationPositive, neutral and negative findings of the study will be published.Registration detailsThe trial is approved by the Regional Ethics Committee in The Capital Region of Denmark (H-2-2011-056) and The Danish Data Protection Agency (2013-41-1710). The trial is registered at ClinicalTrials.gov as NCT01446406.

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Psychomotor activity in affective states

Cited by 14 publications

References 0 publications

Cross-species assessments of motor and exploratory behavior related to bipolar disorder

Cross-species assessments of motor and exploratory behavior related to bipolar disorder

Aktivität und Depression - Möglichkeiten und Grenzen aktigraphischer Verhaltensanalysen -

Daily electronic self-monitoring of subjective and objective symptoms in bipolar disorder—the MONARCA trial protocol (MONitoring, treAtment and pRediCtion of bipolAr disorder episodes): a randomised controlled single-blind trial

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