Psychomotor dysfunction after remifentanil/propofol anaesthesia

Dressler, I; Fritzsche, Thomas; Cortina, Kai S.; Pragst, F.; Spies, Claudia; Rundshagen, I.

doi:10.1017/s0265021506001530

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…It is coincident with other studies which demonstrate that psychomotor and memory function are impaired for only 24 h or less after surgery under propofol anesthesia [27][28][29]. Propofol inhibits synaptic transmission in the central nervous system primarily by enhancing GABA A receptor currents while having smaller effects on NMDA receptor/channels.…”

Section: Discussionsupporting

confidence: 86%

Effect of propofol on local field potential in rat prefrontal cortex during working memory task

Xu¹,

Wang²,

Zhai³

et al. 2012

WJNS

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Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat's prefrontal cortex during working memory task was evaluated. Young (approximately 3 months) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg·kg −1 ·min −1 intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Ymaze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p < 0.05), but had no effect on the third day (p > 0.05). Our results suggest that propofol can impair crosscorrelation coherence of LFPs in the first two days, but not long time.

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Section: Discussionsupporting

confidence: 86%

Effect of propofol on local field potential in rat prefrontal cortex during working memory task

Xu¹,

Wang²,

Zhai³

et al. 2012

WJNS

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“…Dressler et al [4] showed that psychomotor function was impaired until 90 min after surgery under remifentanil-propofol anesthesia. This is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

“…Despite this, monitoring of recovery of psychomotor function is recommended for determination of the observation period after TIVA with remifentanil-propofol. There have so far been few reports on the recovery of psychomotor function after TIVA with remifentanil-propofol [4].…”

Section: Introductionmentioning

confidence: 99%

Recovery of psychomotor function after total intravenous anesthesia with remifentanil–propofol or fentanyl–propofol

et al. 2011

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“…The use of the SST as the best suitable test system was carefully selected between other test systems in this study to investigate the early cognitive recovery, especially memory and attentiveness after general anaesthesia at the day of the operation [11,25,26]. Pre-operatively the mean value of the sum score of the SST was normal and within the same range in both groups.…”

Section: Discussionmentioning

confidence: 99%

Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial

et al. 2010

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BackgroundPerformance of patients immediately after anaesthesia is an area of special interest and so a clinical trial was conducted to compare Xenon with Isoflurane anaesthesia. In order to assess the early cognitive recovery the syndrome short test (SST) according to Erzigkeit (Geromed GmbH) was applied.MethodsASA I and II patients undergoing long and short surgical interventions were randomised to receive either general anaesthesia with Xenon or Isoflurane. The primary endpoint was the validated SST which covering memory disturbances and attentiveness. The test was used on the day prior to intervention, one and three hours post extubation. The secondary endpoint was the recovery index (RI) measured after the end of the inhalation of Xenon or Isoflurane. In addition the Aldrete score was evaluated up to 180 min. On the first post-operative day the patients rated the quality of the anaesthetic using a scoring system from 1-6.ResultsThe demographics of the groups were similar. The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01). The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01). The Aldrete score was significantly higher for 45 min. The scoring system results were also better after Xenon anaesthesia (p < 0.001).ConclusionsThe results show that recovery from anaesthesia and the early return of post-operative cognitive functions are significantly better after Xenon anaesthesia compared to Isoflurane. The results of the RI for Xenon are similar with the previously published results.Trial RegistrationThe trial was registered with the number ISRCTN01110844 http://www.controlled-trials.com/isrctn/pf/01110844.

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Psychomotor dysfunction after remifentanil/propofol anaesthesia

Cited by 19 publications

References 22 publications

Effect of propofol on local field potential in rat prefrontal cortex during working memory task

Effect of propofol on local field potential in rat prefrontal cortex during working memory task

Recovery of psychomotor function after total intravenous anesthesia with remifentanil–propofol or fentanyl–propofol

Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial

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