Psychomotor performance after short-term anaesthesia

Haavisto, E.; Kauranen, Kari

doi:10.1097/00003643-200206000-00006

Cited by 6 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alertness was defined as a finger tapping test result within 10% of the patient's baseline value. 23 During the finger tapping test, patients are instructed to tap a button as fast as they can during a 10-second interval. The baseline number was measured in connection with inclusion in our study.…”

Section: Outcome Measurementsmentioning

confidence: 99%

Efficient Intravenous Access Without Distress

Ekbom

Kalman²,

Jakobsson³

et al. 2011

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

show abstract

Section: Outcome Measurementsmentioning

confidence: 99%

Efficient Intravenous Access Without Distress

Ekbom

Kalman²,

Jakobsson³

et al. 2011

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

show abstract

“…Earlier investigations report that patients may experience side effects even 24–48 h after a single 10‐min administration of propofol (Sanders et al ., ). Anaesthesiological studies also demonstrate that full motor recovery in humans is incomplete for many hours after propofol (Münte et al ., ; Haavisto & Kauranen, ), leading to the general advice that dizziness and drowsiness may persist for 24 h and to caution against driving (http://www.rxlist.com/diprivan-drug/patient-images-side-effects.htm). Thus, our interpretation is that poor recovery of in vitro network function after kainate and propofol was not due to neuronal damage but to lingering consequences of long‐lasting propofol administration.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord in vitro

Kaur

Gutiérrez

Nistri

2016

Eur J of Neuroscience

View full text Add to dashboard Cite

Although neuroprotection to contain the initial damage of spinal cord injury (SCI) is difficult, multicentre studies show that early neurosurgery under general anaesthesia confers positive benefits. An interesting hypothesis is that the general anaesthetic itself might largely contribute to neuroprotection, although in vivo clinical settings hamper studying this possibility directly. To further test neuroprotective effects of a widely used general anaesthetic, we studied if propofol could change the outcome of a rat isolated spinal cord SCI model involving excitotoxicity evoked by 1 h application of kainate with delayed consequences on neurons and locomotor network activity. Propofol (5 μm; 4-8 h) enhanced responses to GABA and depressed those to NMDA together with decrease in polysynaptic reflexes that partly recovered after 1 day washout. Fictive locomotion induced by dorsal root stimuli or NMDA and serotonin was weaker the day after propofol application. Kainate elicited a significant loss of spinal neurons, especially motoneurons, whose number was halved. When propofol was applied for 4-8 h after kainate washout, strong neuroprotection was observed in all spinal areas, including attenuation of motoneuron loss. Although propofol had minimal impact on recovery of electrophysiological characteristics 24 h later, it did not further depress network activity. A significant improvement in disinhibited burst periodicity suggested potential to ameliorate neuronal excitability in analogy to histological data. Functional recovery of locomotor networks perhaps required longer time due to the combined action of excitotoxicity and anaesthetic depression at 24 h. These results suggest propofol could confer good neuroprotection to spinal circuits during experimental SCI.

show abstract

“…A large variability has been associated with neuropsychological testing (1), and differences in the number and types of neuropsychological tests used are key issues of the methodological difficulties that can be identified when different types of studies are compared (2). A reaction time test is easily carried out and impairment has been detected during recovery after anaesthesia (3, 4). The first International Study of Post‐operative Cognitive Dysfunction (ISPOCD1) undertook the largest study of POCD after non‐cardiac surgery to date and choice reaction time (CRT) was determined in the ISPOCD1 study, but this variable was not included in the final outcome measure (5).…”

mentioning

confidence: 99%