Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers

Sabbe, Bernard; Hulstijn, Wouter; Maes, Michaël; Pier, M.P.B.I.; Zitman, Frans G.

doi:10.1016/s0165-1781(01)00326-2

Cited by 21 publications

(12 citation statements)

References 43 publications

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“…Despite its interaction with other classes of monoaminergic receptor (Gatch 2003), its motor-depressant actions are mediated by 5-HT 2C receptors and reflect inhibition of dopaminergic transmission (Gleason et al 2001;Walker et al 2005;Stark et al 2006). Correspondingly, blockade of mCPP-induced hypolocomotion by S32006 may be related to an alleviation of psychomotor slowing in depression (Sabbe et al 2001;Gatch 2003). While blockade of mCPP-locomotion might simply be a "pharmacological" interaction, S32006 also reversed motor-depressant actions of the α 2 -AR agonist, S18616.…”

Section: Modulation Of Frontocortical Monoaminergic Transmissionmentioning

confidence: 99%

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

et al. 2008

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Section: Modulation Of Frontocortical Monoaminergic Transmissionmentioning

confidence: 99%

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

et al. 2008

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“…Electrophysiological studies have also revealed that a specific antagonist of 5-HTR2C markedly increases dopamine and noradrenaline release in the frontal cortex, whereas a selective agonist has the opposite effect [14,15] . Moreover, a selective 5-HTR2C agonist (mCPP) elicits human psychomotor slowing, a typical symptom of depression [16] . Behavioral effects of antidepressant drugs also support the role of this receptor in the pathogenesis of depression.…”

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confidence: 99%

Antidepressant Treatments Change 5-HT2C Receptor mRNA Expression in Rat Prefrontal/Frontal Cortex and Hippocampus

et al. 2011

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Background/Aims: Compelling evidence would suggest the involvement of the serotonin 2C receptor in the pathophysiology of affective disorders and in the action of antidepressants. We analyzed the time course of 5-HT2C receptor (5-HTR2C) mRNA expression during antidepressant treatment in the prefrontal/frontal cortex (P/FC) and in the hippocampus (HC) of rats chronically treated with fluoxetine (a selective serotonin reuptake inhibitor) and reboxetine (a selective noradrenaline reuptake inhibitor). We also analyzed the 5-HTR2C RNA-editing levels at the sites called A, B, C, C’ and D, which are known to modulate 5-HTR2C receptor function. Results: The expression profile of 5-HTR2C mRNA was modified during treatment with both antidepressants. In particular, we found a general down-regulation of 5-HTR2C mRNA expression in P/FC, which became significant after 3 weeks of treatment with both antidepressants and persisted after a fourth week of drug withdrawal (–46% with fluoxetine, –41% with reboxetine, p < 0.05). In HC, however, reboxetine induced significant down-regulation (–56%, p < 0.05) of 5-HTR2C mRNA after 3 weeks, while fluoxetine induced threefold up-regulation (p < 0.01) by the 2nd and 3rd week, returning to the base level after drug withdrawal of both antidepressants. Moreover, the frequency of 5-HTR2C-edited isoforms showed no significant alterations, although analysis of the RNA-editing level at the single editing sites showed small decreases in the C’ and D sites induced by reboxetine in P/FC. Conclusion: Our results suggest that chronic administration of antidepressants in rats slightly modifies the editing levels of 5-HT2C receptor but has considerable influence on its mRNA expression patterns in a way that is area- and time-specific.

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“…These data thus show that abstinent alcoholics have more difficulties in motor processing when task conditions become more difficult than healthy controls. Motor processing involves movement programming and initiation, agonist and antagonist muscle groups' coordination, response execution (= motor act), and feedback monitoring (Sabbe et al, 2001). Disorders in motor performance particularly in smooth and timed movements have been associated with cerebellar damage (Gilman, 1994).…”

Section: Discussionmentioning

confidence: 99%

Motor Functioning and Alcohol Dependence

Wilde

Dom

Hulstijn

et al. 2007

Alcoholism Clin & Exp Res

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These research data indicate that abstinent alcoholics are somewhat impaired on a behavioral level. The execution of timed responses indeed was lengthier in abstinent alcoholics than in healthy controls. As both cognitive and motor processes were impaired, we here assume that both central and peripheral processes are affected by progressive alcohol intake. Abstinent alcoholics also have more difficulties to adapt their motor responses to changing task conditions.

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Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers

Cited by 21 publications

References 43 publications

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

Antidepressant Treatments Change 5-HT2C Receptor mRNA Expression in Rat Prefrontal/Frontal Cortex and Hippocampus

Motor Functioning and Alcohol Dependence

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