Psychopathological Comorbidities and Clinical Variables in Patients With Medication Overuse Headache

Migliore, Simone; Paolucci, Matteo; Quintiliani, Livia; Altamura, Claudia; Maffi, Sabrina; D’Aurizio, Giulia; Curcio, Giuseppe; Vernieri, Fabrizio

doi:10.3389/fnhum.2020.571035

Cited by 12 publications

(14 citation statements)

References 24 publications

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“…However, the MOH group reported mild to moderate depression symptoms. Our results confirm the findings from previous studies, investigating the behavioral and psychopathological profile of patients with MOH (1,27). Regarding the dissociative aspects, in our study, there were no differences among the three groups, even if few studies demonstrated that dissociative symptoms are more frequent in patients with migraine and, in particular, in chronic forms of migraine (28).…”

Section: Discussionsupporting

confidence: 92%

Theory of Mind in migraine and medication-overuse headache: A cross-sectional study

et al. 2022

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BackgroundTheory of Mind (ToM) is the ability to predict and anticipate others' behaviors through the mental state attribution process. This study aims to investigate the ToM in patients with medication-overuse headache (MOH) and episodic migraine (EM) and to compare it with healthy controls (HC).MethodsThis study enrolled patients with MOH, patients with EM, and HC. ToM was assessed through the Theory of Mind Assessment Scale (ThOMAS), which includes four subscales: Scale A, I-Me, Scale B, Other-Self, Scale C, I-Other, and Scale D, Other-Me, through the Reading the Mind in the Eyes test (RMET), which measures complex emotion recognition, and through the Toronto Alexithymia Scale (TAS-20), which measures alexithymia. Concomitant psychiatric disturbances were evaluated through the Hamilton Anxiety Rating Scale, the Hamilton Depression Rating Scale, and the Dissociative Experiences Scale-II.ResultsThe study involved 21 patients with EM, 22 patients with MOH, and 18 HC. In all the four subscales of the ThOMAS, there was a significant difference between HC, EM, and MOH patients: Scale A (p = 0.009), Scale B (p = 0.004), Scale C (p = 0.039), and Scale D (p = 0.008). In the RMET, MOH patients had worse performances than EM patients and HC (p = 0.039). MOH group exhibited higher levels of alexithymia when compared to the HC (p = 0.033) and higher levels of anxiety than HC (p = 0.001).ConclusionMOH patients showed a subtle psychopathological pattern characterized by impaired social adaptation.

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Section: Discussionsupporting

confidence: 92%

Theory of Mind in migraine and medication-overuse headache: A cross-sectional study

et al. 2022

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“…18,21,22 Our data have this trend, although there was no significant difference. On the other hand, although psychiatric comorbidities such as anxiety, depression, and others, plus altered hormone levels associated with mood swings in women over 40 years of age 7,23 , could lead to CDH and MOH, we found no significant differences for MOH in this subgroup. Shand et al 11 reported that the overused drugs that led to the development of MOH in Argentina and Chile were combined ergotamine (70%) and NSAIDs (33.8%).…”

Section: Discussioncontrasting

confidence: 79%

“…Several studies have determined associations with polymorphic variants related to the susceptibility of conversion to MOH 6 , psychopathological comorbidities 7 , within these, post-traumatic stress events 8 , depression, anxiety and insomnia 9 , and other sociodemographic factors, such as low education, place of residence, limited medical contact and type of medical care received in the development of MOH. [10][11][12][13] Factors that, in addition to transforming EM and ETTH into CM and CTTH [7][8][9]14,15 , induce patients to seek different types of medical attention and to overuse medication in an effort to obtain relief from their pain. [16][17][18][19] There is no clear evidence regarding the association of MOH with the type of medical care received.…”

Section: Introductionmentioning

confidence: 99%

Higher frequency of medication overuse headache in patients attended by neurologists in Lima, Peru

Novoa

Bordini

2021

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BackgroundThe type of medical care received (self-medication and/or medical care provided by a general practitioner or a neurologist) may be associated with differences in the frequency of medication overuse headaches.MethodThis cross-sectional analytical study included 222 records of patients with chronic daily headaches seen at the National Institute of Neurological Sciences Outpatient Unit in Lima, Peru. A pre-designed questionnaire was used to assess and categorize patients with frequent and chronic headaches.ResultsNinety-four patients (42.34% of those with chronic daily headaches) met the criteria for medication overuse headache. Of these, 19 (28%) self-medicated, 22 (36%) consulted with the general practitioner, and the highest proportion of subjects, 53 (58%), consulted with a neurologist. On bivariate analysis, subjects who had received care from a general practitioner and self-medicated were 38% and 51% less likely to have MOH than the subjects whoreceived medical care from the neurologist (p=0.012; 95% CI 0.42-0.90 and p=0.001; 95% CI 0.32-0.74). On multivariate analysis adjusting by sociodemographic and clinical factors, the association remained significant in regards to self-medication, but became marginal (p=0.055) in regard to being seen by a general practitioner.ConclusionIn this study, the frequency of the headache due to overuse of medication was higher in patients attending a neurologist than those attending a general practitioner or self-medicated. This cross-sectional design cannot assess whether this reflects more severe cases looking for specialized care or more medication overuse headaches as a result of inappropriate management.

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“…23,24 Increasing headache frequency was associated with risk of occurrence of anxiety, depression, and insomnia, 25 and higher migraine frequency was correlated with greater symptom scores of anxiety and depression. 26 MOH patients showed a high rate of depression and anxiety, which could negatively affect their headache attack, 27 and depression and anxiety were found to be negative predictors in terms of treatment response in chronic migraine patients with or without medication-overuse. [28][29][30] Moreover, lowered depression scores predicted a positive outcome of MOH detoxification.…”

Section: Discussionmentioning

confidence: 95%

Cognitive Function and White Matter Lesions in Medication-Overuse Headache

Xiang¹,

Chen²,

Lin³

et al. 2021

JPR

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Purpose This study was designed to investigate the cognitive function and the white matter lesions (WMLs) and the relationship between them in medication-overuse headache (MOH) patients. Methods Subjects were enrolled and performed Montreal Cognitive Assessment (MoCA, Chinese-Beijing Version), Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD-24), and Pittsburgh Sleep Quality Index (PSQI) to evaluate the general cognitive function, anxiety, depression and sleep quality, and they were divided into three groups according to the MoCA scores: healthy controls, MOH with normal cognition group and MOH with cognitive impairment group. All the participants underwent MRI scans and images were obtained for WML evaluation with Fazekas scale. Results One hundred thirty-four participants were enrolled into this study, 46 of them for healthy controls, and 88 for MOH patients, 40 of the MOH patients for MOH with cognitive impairment group, and 48 for MOH with normal cognition group. MOH patients had significantly lower MoCA scores, including the scores of visuospatial and executive function, attention, and orientation, while they had significantly greater HAMA scores, HAMD-24 scores, PSQI scores, and deep white matter hyperintensity scores compared to healthy controls. And in MOH patients, the age, disease duration, monthly headache days, and periventricular white matter hyperintensity scores in patients with cognitive impairment were greater than those in patients with normal cognition. Moreover, the MoCA scores were negatively related to age, disease duration, monthly headache days, and Fazekas scale scores, and disease duration and monthly headache days were significant predictors of cognitive impairment in MOH patients. Conclusion MOH patients showed cognitive impairment and increased WML burden. And in MOH patients, cognitive function was negatively related to WML burden, and disease duration and monthly headache days were potential predictors of cognitive impairment. Prompt and effective treatment to stop the progression of the disease may alleviate cognitive impairment in MOH patients.

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Psychopathological Comorbidities and Clinical Variables in Patients With Medication Overuse Headache

Cited by 12 publications

References 24 publications

Theory of Mind in migraine and medication-overuse headache: A cross-sectional study

Theory of Mind in migraine and medication-overuse headache: A cross-sectional study

Higher frequency of medication overuse headache in patients attended by neurologists in Lima, Peru

Cognitive Function and White Matter Lesions in Medication-Overuse Headache

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