Psychopathological symptoms and magnetic resonance imaging findings in multiple sclerosis

Reischies, Friedel M.; Baum, K.; Nehrig, C.; Schörner, W.

doi:10.1016/0006-3223(93)90113-r

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…33 Honer et al 34 found that MRI abnormalities were more common in the temporal lobes in patients with mixed types of psychopathology than in patients without neuropsychiatric symptoms. Reischies et al 29 failed to find any relationship between depression and periventricular lesion scores, although they did demonstrate relationships with euphoria and irritability. Ron and Logsdail 30 found no association between global measures of psychiatric disability and MRI changes, but they reported a correlation between delusions and the degree of pathology in the temporoparietal regions.…”

Section: Manifestations Of Multiple Sclerosismentioning

confidence: 95%

“…We found irritability (35%), apathy (20%), and disinhibition (13%) in our MS patients. Reischies et al 29 identified a significant correlation between periventricular lesion score and an irritability measure. The NPI reveals that personality changes are among the most common changes of MS and will not be detected by tools that lack questions concerning this aspect of behavior.…”

Section: Manifestations Of Multiple Sclerosismentioning

confidence: 98%

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Neuropsychiatric Manifestations of Multiple Sclerosis

Dı́az-Olavarrieta¹,

Cummings²,

Velázquez³

et al. 1999

JNP

214

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The range of neuropsychiatric symptoms in multiple sclerosis (MS) has not been prospectively assessed. The authors, working at a tertiary medical center in Mexico City, used the Neuropsychiatric Inventory (NPI) to evaluate neuropsychiatric symptoms prospectively in 44 MS patients who were stable between relapses and 25 control subjects of similar age, education, and cognitive function. Neuropsychiatric symptoms were present in 95% of patients and 16% of control subjects. Changes present were depressive symptoms (79%), agitation (40%), anxiety (37%), irritability (35%), apathy (20%), euphoria (13%), disinhibition (13%), hallucinations (10%), aberrant motor behavior (9%), and delusions (7%). The only relationships with MRI were between euphoria and hallucinations and moderately severe MRI abnormalities. The authors conclude that diverse types of neuropsychiatric symptoms are common in MS; symptoms are present between exacerbations; and there are variable correlations with MRI abnormalities.

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Section: Manifestations Of Multiple Sclerosismentioning

confidence: 95%

Section: Manifestations Of Multiple Sclerosismentioning

confidence: 98%

Neuropsychiatric Manifestations of Multiple Sclerosis

Dı́az-Olavarrieta¹,

Cummings²,

Velázquez³

et al. 1999

JNP

214

View full text Add to dashboard Cite

show abstract

“…Neuropsychological data on deficits of frontal lobe functions in patients with depression syndromes (e.g., Ref. 7) together with subcortical vascular lesions (deep white matter lesions, DWML 3) as probable neuropathological correlates support the idea that a dysfunction of the frontal lobe and frontal cortico‐subcortical projection loops may be factors in the pathophysiology of depression.…”

Section: Introductionmentioning

confidence: 83%

“…However, a major problem is that lesion studies have demonstrated (1) apathy without depressed mood (pseudodepression) after lesions of mediodorsal prefrontal cortex, and more specifically (2) euphoria with disinhibition 9 after ventral frontal lesions or their subcortical afferent and efferent connections. 5,7 The relation of frontal lobe dysfunction and depressed mood has to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Pattern of Disturbance of Different Ventral Frontal Functions in Organic Depression

Reischies

1999

Annals of the New York Academy of Sciences

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“…Most MRI studies of patients with MS found a correlation between the cognitive and/or affective disorders, on the one hand, and lesion localization [128], total lesion load [129] or cerebral atrophy, on the other [129,130]. A significant correlation was also reported between abnormal activities in specific cortical zones on fMRI, on the one hand, and clinical manifestation, conventional MRI findings and behavioral changes, on the other [94].…”

Section: Social Cognition Impairments In Patients With Multiple Sclermentioning

confidence: 99%

Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

Ignatova¹,

Todorova²,

Surchev³

2016

Trending Topics in Multiple Sclerosis

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Cognitive impairments in multiple sclerosis (MS) are heterogeneous and their rate varies between 43% and 70%. A less studied aspect of cognition is social cognition, which is not a uniform theoretical construct. It includes emotion perception, prosody, empathy, theory of mind (ToM) and assessment of mood. In addition to progressive physical disability, social cognitive impairments are a reason for job loss in 24-80% of patients with MS, increased divorce rate, dissolution of partnerships and social communication difficulties.Social cognitive impairments are the result of disruptions in the mentalization network at the neuroanatomical, neurochemical and/or genetic level, which can lead to malfunctions in the dopaminergic-serotoninergic system and to compromising the development of neuroanatomical targets within the network. The wide dissemination of demyelinating lesions and cortical thinning typical of patients with MS often lead to anatomic and functional disorders of the above-mentioned specific brain structures. A correlation has been established among specific cortical areas involved in emotion identification from facial expression (right and left fusiform face area, frontal eye), emotion processing (right entorhinal cortex) and socially relevant information (left temporal pole). The most active brain region involved in social cognitive processing is the medal frontal cortex (MFC), which is described as the brain's social cognitive center. During performance of various sociocognitive tasks for mental state attribution, common areas of increased activation in the medial prefrontal gyrus and the temporoparietal junctions are registered bilaterally, while the area of the medial prefrontal cortex (the paracingulate cortex) is the only region uniquely activated by the performance of ToM.Most MRI studies of patients with MS found a correlation between the cognitive and/or affective disorders, on the one hand, and lesion localization, total lesion load, or cerebral atrophy, on the other. A significant correlation was also reported between © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.abnormal activities in specific cortical zones on fMRI, on the one hand, and clinical manifestation, conventional MRI findings and behavioral changes, on the other. Altered patterns of brain activity were found in all clinical phenotypes of MS, including when cognitive abilities were intact and/or restored, social cognitive dysfunction in MS actually affects all stages of the disease and all types of clinical course. The cortical plastic changes are a dynamic phenomenon that can be modulated by external factors. This phenomenon would facilitate the mapping of individual strategies for adequate treatment and rehabilitation of each patient.

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Psychopathological symptoms and magnetic resonance imaging findings in multiple sclerosis

Cited by 13 publications

References 11 publications

Neuropsychiatric Manifestations of Multiple Sclerosis

Neuropsychiatric Manifestations of Multiple Sclerosis

Pattern of Disturbance of Different Ventral Frontal Functions in Organic Depression

Social Cognition Impairments in Patients with Multiple Sclerosis and Comparison with Imaging Studies, Disease Duration and Grade of Disability

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