Psychopathology and Social Competencies of Adolescents Who Were Extremely Low Birth Weight

Saigal, Saroj; Pinelli, Janet; Hoult, Lorraine; Kim, M. Marie; Boyle, Michael

doi:10.1542/peds.111.5.969

Cited by 196 publications

(185 citation statements)

References 52 publications

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“…Follow-up studies have shown that these children are often confronted with developmental problems and psychiatric diagnoses in late childhood and early adolescence (2)(3)(4)(5)(6)(7)(8)(9). Studies also suggest a link between extreme prematurity and autism spectrum disorder (ASD), characterised by persistent deficits in social communication and social interaction, and restrictive and repetitive patterns of behaviours, interests or activities (10).…”

Section: Introductionmentioning

confidence: 99%

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Verhaeghe

Dereu

Warreyn

et al. 2015

Child Psychiatry Hum Dev

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This study aimed to provide a more comprehensive picture of the prevalence of autism spectrum disorder (ASD) in a geographic cohort of extremely preterm born adolescents by using established diagnostic instruments in addition to screening instruments. 53 participants passed a screening procedure with two screening instruments and a diagnostic evaluation with a semistructured assessment and a parent interview. 28% of the adolescents had a community based clinical diagnosis of ASD. When research diagnoses were also taken into account, this rate increased to 40%. Intellectual disability, language impairment and behavioural difficulties are characteristic for these children with ASD. This study is to our knowledge the first to use ASDspecific diagnostic instruments to confirm ASD diagnoses in extremely preterm born children in early adolescence. The study expands findings of previous research and raises the need for follow-up into late childhood and early adolescence.

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Section: Introductionmentioning

confidence: 99%

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Verhaeghe

Dereu

Warreyn

et al. 2015

Child Psychiatry Hum Dev

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“…Beyond somatic growth, IUGR also impacts brain development, thus increasing the risk for later neurological complications (24). In the present study, we focused our attention on brain hippocampal metabolism and gene expression at PND7, a late neuronal proliferative phase in the rat, documenting for the first time alterations of this tissular development due to DEX-induced IUGR and the potential reversal of these alterations by bLf supplementation.…”

Section: Discussionmentioning

confidence: 98%

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

et al. 2013

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Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf ) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. Methods: IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pups growth was monitored, and pup brain metabolism and gene expression were studied using in vivo 1 H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7. results: Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pup (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation. conclusion: Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.

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“…3 In case of missing data, authors were contacted. 5,28,32,[36][37][38] Some authors were not able to provide missing data 5,28 or could not be reached. 39 These studies, therefore, were not included in the meta-analysis.…”

Section: Behavioral Problemsmentioning

confidence: 99%

“…The incidence of major disabilities such as cerebral palsy, mental retardation, deafness, or blindness is fairly low. 1 There is growing awareness that the majority of nondisabled survivors encounter more "subtle" problems such as academic underachievement, 2 behavioral problems, [3][4][5] and deficits in higher-order neurocognitive functions: the so-called executive functions (EFs), 6 which persist throughout childhood and young adulthood. 1,4,7 However, great variability exists in the published results because of small numbers of participants, high attrition rates, and substantial variations in methods and study design.…”

mentioning

confidence: 99%

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

et al. 2009

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Birth Weight Children Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Lowhttp://www.pediatrics.org/cgi/content/full/124/2/717 located on the World Wide Web at:The online version of this article, along with updated information and services, is Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children abstract OBJECTIVE: Sequelae of academic underachievement, behavioral problems, and poor executive function (EF) have been extensively reported for very preterm (Յ33 weeks' gestation) and/or very low birth weight (VLBW) (Յ1500 g) children. Great variability in the published results, however, hinders the field in studying underlying dysfunctions and developing intervention strategies. We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains.METHODS: Suitable for inclusion were 14 studies on academic achievement, 9 studies on behavioral problems, and 12 studies on EF, which compared a total of 4125 very preterm and/or VLBW children with 3197 term-born controls. Combined effect sizes for the 3 outcome domains were calculated in terms of Cohen's d. Q-test statistics were performed to test homogeneity among the obtained effect sizes. Pearson's correlation coefficients were calculated to examine the impact of mean birth weight and mean gestational age, as well as the influence of mean age at assessment on the effect sizes for academic achievement, behavioral problems, and EF. RESULTS:Combined effect sizes show that very preterm and/or VLBW children score 0.60 SD lower on mathematics tests, 0.48 SD on reading tests, and 0.76 SD on spelling tests than term-born peers. Of all behavioral problems stacked, attention problems were most pronounced in very preterm and/or VLBW children, with teacher and parent ratings being 0.43 to 0.59 SD higher than for controls, respectively. Combined effect sizes for parent and teacher ratings of internalizing behavior problems were small (Ͻ0.28) and for externalizing behavior problems negligible (Ͻ0.09) and not significant. Combined effect sizes for EF revealed a decrement of 0.57 SD for verbal fluency, 0.36 SD for working memory, and 0.49 SD for cognitive flexibility in comparison to controls. Mean age at assessment was not correlated with the strength of the effect sizes. Mathematics and reading performance, parent ratings of internalizing problems, teacher ratings of externalizing behavior, and attention problems, showed strong and positive correlations with mean birth weight and mean gestational age (all r values Ͼ 0.51). CONCLUSIONS:Very preterm and/or VLBW children have moderate-toseveredeficitsinacademicachievement,attentionproblems,andinternalizing behavioral problems and poor EF, which are adverse outcomes that were strongly correlated to their immaturity at birth. During transition to young adulthood these children continue to lag behind term-born peers.

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Psychopathology and Social Competencies of Adolescents Who Were Extremely Low Birth Weight

Cited by 196 publications

References 52 publications

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

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