Psychopathology in Adolescent Offspring of Parents With Panic Disorder, Major Depression, or Both: A 10-Year Follow-Up

Hirshfeld‐Becker, Dina R.; Micco, Jamie A.; Henin, Aude; Petty, Carter R.; Faraone, Stephen V.; Mazursky, Heather; Bruett, Lindsey; Rosenbaum, Jerrold F.; Biederman, Joseph

doi:10.1176/appi.ajp.2012.11101514

Cited by 51 publications

(40 citation statements)

References 33 publications

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“…However, it is possible that the rates of psychopathology in OPR were higher before the parental affective episode remitted. The higher rates of depressive disorders found in our study in OPM can be explained, at least in part, by the excessive rate of anxiety and SUDs of their parents 40 . Unfortunately, we could not compare our results with other studies because no other study to date has examined reports given by parents with manic/hypomanic symptoms and parents with BP in remission.…”

Section: Discussionmentioning

confidence: 41%

The Effects of Parental Mood on Reports of Their Children’s Psychopathology

Maoz

Goldstein

et al. 2014

Journal of the American Academy of Child & Adolescent Psych

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Objective In this study, we aim to assess whether current mood state (depressed or manic/hypomanic) among parents with a mood disorder affects their reports of their offspring's psychopathology. Method Sixty-five parents with current depression, 42 with current mania/hypomania, 181 with mood disorder in remission, and their offspring (n=479, ages 6-18) completed assessments of offspring IP psychopathology as part of the Pittsburgh Bipolar Offspring Study (BIOS). We compared rates of offspring psychopathology assessed using the following: a clinician-administered semi-structured interview with parent and child using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS); parent-reported Child Behavior Checklist (CBCL); offspring self-reported Youth Self Reports (YSR) for those 11 years and older (n=250); and teachers’ reports when available (n= 209). Results There were no between-group differences in rates of psychopathology yielded from the K-SADS, except for more depressive disorders in offspring of parents with current mania/hypomania compared to offspring of parents in remission. Conversely, using the CBCL and comparing with parents who were in remission, parents with current depression reported significantly more externalizing psychopathology in offspring, whereas parents with current mania/hypomania reported more externalizing and internalizing psychopathology in their offspring. On the YSR, offspring of parents with current mania/hypomania had more internalizing psychopathology compared to offspring of parents in remission. Teacher's reports showed no between-group differences in rates of any psychopathology. Conclusion Parental active mood symptomatology, especially during a manic/hypomanic episode, significantly affects their reports of their offspring's psychopathology. Trained interviewers reduce potential report bias. Clinicians and studies assessing children's psychopathology should take into account parental current mood state.

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Section: Discussionmentioning

confidence: 41%

The Effects of Parental Mood on Reports of Their Children’s Psychopathology

Maoz

Goldstein

et al. 2014

Journal of the American Academy of Child & Adolescent Psych

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“…However, we did exclude children with known developmental delays such as autism and intellectual disability. Second, because parental MDD confers a spectrum of risk to offspring (31,69), the at-risk children were also at risk for anxiety and other disorders. Parents with MDD also have higher rates of comorbid anxiety than the general population.…”

Section: Discussionmentioning

confidence: 99%

10.3 Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression

Uchida

2016

Journal of the American Academy of Child & Adolescent Psych

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“…General risk factors for psychiatric difficulties in children include: genetic risk factors [5,6], parental and maternal poor physical and mental health [7][8][9][10][11][12][13], as well as prenatal [14,15], obstetrical complications [16], low socio-economic status (single-parent family, low educational or income level, food insecurity) [17][18][19][20][21][22][23], negative life events [11,22], low social networks and support [23], as well as domestic violence [24][25][26] and child maltreatment [26][27][28][29][30]. Children growing up in homeless families are disproportionately exposed to many of these exposures and experiences.…”

Section: Introductionmentioning

confidence: 99%

Emotional and behavioral difficulties in children growing up homeless in Paris. Results of the ENFAMS survey

et al. 2016

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Purpose: Children growing up in homeless families are disproportionately more likely to experience health and psychological problems. Our objective was to describe social, environmental, individual and family characteristics associated with emotional and behavioral difficulties among homeless children living in the Paris region.Methods: Face-to-face interviews with a representative sample of homeless families were conducted by bilingual psychologists and interviewers between January and May 2013 (n=343 children ages 4- years). Mothers reported children's emotional and behavioral difficulties (Strength and DifficultiesQuestionnaire -SDQ), family socio-demographic characteristics, residential mobility, and parents' and children's physical and mental health. Children were interviewed regarding their perception of their living arrangements, friendships and school experiences. We studied children's SDQ total score in a linear regression framework.Results: Homeless children had higher SDQ total scores than children in the general population of France, (mean total score =11.3 vs 8.9, p<0,001). In multivariate analyses, children's difficulties were associated with parents' region of birth (beta=1.74 for Sub-Saharan Africa, beta=0.60 for Eastern Europe, beta=3.22 for other countries, p=0.020), residential mobility (beta=0.22, p=0.012), children's health (beta=3.49, p<0.001) and overweight (beta=2.14, p=0.007), the child's sleeping habits (beta=2.82, p=0.002), the mother's suicide risk (beta=4.13, p<0.001), the child's dislike of the family's accommodation (beta=3.59, p<0.001) and the child's experience of bullying (beta=3.21, p=0.002). Conclusions:Children growing up homeless experience high levels of psychological difficulties which can put them at risk for poor mental health and educational outcomes long-term. Access to appropriate screening and medical care for this vulnerable yet underserved group are greatly needed.

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Psychopathology in Adolescent Offspring of Parents With Panic Disorder, Major Depression, or Both: A 10-Year Follow-Up

Abstract: At-risk offspring continue to develop new disorders as they progress through adolescence. These results support the need to screen and monitor the offspring of adults presenting for treatment of panic disorder or major depressive disorder.

Cited by 51 publications

References 33 publications

The Effects of Parental Mood on Reports of Their Children’s Psychopathology

The Effects of Parental Mood on Reports of Their Children’s Psychopathology

10.3 Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression

Emotional and behavioral difficulties in children growing up homeless in Paris. Results of the ENFAMS survey

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